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McGill researchers discover brain cells that play key role in leptin sensing, weight gain

It's rare for scientists to get what they describe as "clean" results without spending a lot of time repeating the same experiment over and over again. But when researchers saw the mice they were working with doubling their weight within a month or two, they knew they were on to something.

13 May 2016

MUSC Hollings Cancer Center receives $8.9 million grant to explore signaling in sphingolipids

The Medical University of South Carolina's Hollings Cancer Center received an $8.9 million grant from the National Cancer Institute designed to foster collaboration across clinical and laboratory research for the study of signaling in sphingolipids, a class of lipids known to be involved in the growth of solid tumor cancers.

10 May 2016

Study reveals new cell-signaling pathway that detects chromosome missegregation

A recent research study at The Hormel Institute, University of Minnesota is providing insight into the regulation of chromosome segregation and the mechanisms used by cells to prevent them from forming tumors.

4 May 2016

Researchers identify 43 specific genes associated with both autism and cancer

Autism and cancer share more than 40 risk genes, suggesting that common mechanisms underlying the functions of some of these genes could conceivably be leveraged to develop therapies not just for cancer but for autism as well, an extensive assessment by researchers with the UC Davis MIND Institute and Comprehensive Cancer Center has found.

4 May 2016

Key method to test compounds for anti-cancer activity in cells flawed, study reveals

The primary method used to test compounds for anti-cancer activity in cells is flawed, Vanderbilt University researchers report May 2 in Nature Methods. The findings cast doubt on methods used by the entire scientific enterprise and pharmaceutical industry to discover new cancer drugs.

3 May 2016

Predictive statistical approach opens door to development of more effective therapies for breast cancer

Designing effective new drugs, especially drugs to fight cancer, demands that you know as much as you can about the molecular workings of cancer growth. Without that, it's like planning to fight a war against an enemy you've never seen.

29 Apr 2016

Novel gene therapy can improve symptoms of Bubble Boy disease in young adults

Adolescents and young adults with a severe inherited immunodeficiency disorder improved following treatment with novel gene therapy developed at St. Jude Children's Research Hospital and at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. The results of this study appear today in the journal Science Translational Medicine.

21 Apr 2016

MicroRNA controls tumor cell proliferation in most aggressive large B-cell lymphoma

A recent study by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine showed that a microRNA called miR-181a dampens signals from the cancer-driving NFκB protein pathway in the most aggressive large B-cell lymphomas (DLBCL). By reducing NFκB signaling, miR-181a controls tumor cell proliferation and survival and could be the target of novel therapies. The study was published in the journal Blood.

2 Apr 2016

Targeted therapies suppress T cell activity that could actually help fight tumors

In many cases, targeted therapies for cancer are preferred as treatments over chemotherapy and surgery because they attack and kill cancer cells with specific tumor-promoting mutations while sparing healthy, normal cells that do not express these mutations.

23 Mar 2016

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Cobimetinib (trade name: Cotellic) has been approved since November 2015 in combination with vemurafenib for the treatment of adults with advanced, i.e. metastatic or unresectable, melanoma with a BRAF V600 mutation.

21 Mar 2016

ROBO1 protein may delay progression of breast cancer

A protein called ROBO1 may delay the progression of breast cancer, according to a paper published in The Journal of Cell Biology. The study, "Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness" by Lily Thao-Nhi Le and colleagues, identifies a signaling pathway that may protect breast cells from the tumorigenic effects of stiff extracellular matrices.

16 Mar 2016

Scientists find surprising link between iPS cell reprogramming, blood cell formation and cancer

The ability to reprogram cells has revolutionized stem cell research with major implications for almost all fields of modern biology. A decade ago Shinya Yamanaka described a procedure that revolutionized stem cell biology. Using a genetic trick that introduces a cocktail of four genes into cultured cells from human biopsies, he was able to generate induced pluripotent stem cells (iPS) from mature skin or blood cells

15 Mar 2016

Alcohol consumption may increase risk for breast cancer

A University of Houston researcher and his team have discovered an important link between alcohol and breast cancer by identifying a cancer-causing gene triggered by alcohol

15 Mar 2016

Multi-gene test can help identify early breast cancer patients who can safely be spared chemotherapy

Researchers have shown for the first time that it is possible to use a multi-gene test to identify patients with early breast cancer who can be spared chemotherapy and who will still be alive and well five years after diagnosis.

11 Mar 2016

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

microRNAs (miRs) are small endogenous noncoding RNA molecules (20–23 nucleotides) derived from imperfectly paired hairpin RNA structures naturally encoded in the genome that act specifically as triggering molecules to control translational repression or mRNA degradation.

11 Mar 2016

New drug combination treatment makes breast cancer tumours disappear in just 11 days

Approximately a quarter of women with HER2 positive breast cancer, who were treated with a combination of the targeted drugs lapatinib and trastuzumab before surgery and chemotherapy, saw their tumours shrink significantly or even disappear, according to results from a clinical trial.

11 Mar 2016

Scientists discover novel drug candidate to treat breast cancer, lung cancer and melanoma

Using a new approach, scientists at The Scripps Research Institute and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma.

10 Mar 2016

Absence of PEMT enzyme leads to development of fatty liver disease and tumours in thin patients

Researchers observe protection against obesity and insulin resistance but at the cost of prominent fatty liver disease in mice lacking the PEMT enzyme and patients with low levels of PEMT.

7 Mar 2016

Study provides critical insight into Warburg effect

PGK1, a glycolytic enzyme, has been found to play a role in coordinating cellular processes crucial to cancer metabolism and brain tumor formation, according to results published in today's online issue of Molecular Cell. The findings may lay the groundwork for improved approaches to diagnosis and treatment of glioblastoma and other cancers.

4 Mar 2016

Aggregated forms of transthyretin can trigger JIA development

Juvenile idiopathic arthritis (JIA) is a the most common form of arthritis in children and affects approximately 50,000 individuals in the United States alone. Previous research suggested that autoimmune responses cause JIA, but the specific antigens that are responsible for driving autoimmunity have not been identified.

26 Feb 2016

Cell Proliferation News and Research

McGill researchers discover brain cells that play key role in leptin sensing, weight gain

MUSC Hollings Cancer Center receives $8.9 million grant to explore signaling in sphingolipids

Study reveals new cell-signaling pathway that detects chromosome missegregation

Researchers identify 43 specific genes associated with both autism and cancer

Key method to test compounds for anti-cancer activity in cells flawed, study reveals

Predictive statistical approach opens door to development of more effective therapies for breast cancer

Novel gene therapy can improve symptoms of Bubble Boy disease in young adults

MicroRNA controls tumor cell proliferation in most aggressive large B-cell lymphoma

Targeted therapies suppress T cell activity that could actually help fight tumors

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

ROBO1 protein may delay progression of breast cancer

Scientists find surprising link between iPS cell reprogramming, blood cell formation and cancer

Alcohol consumption may increase risk for breast cancer

Multi-gene test can help identify early breast cancer patients who can safely be spared chemotherapy

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

New drug combination treatment makes breast cancer tumours disappear in just 11 days

Scientists discover novel drug candidate to treat breast cancer, lung cancer and melanoma

Absence of PEMT enzyme leads to development of fatty liver disease and tumours in thin patients

Study provides critical insight into Warburg effect

Aggregated forms of transthyretin can trigger JIA development

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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