Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Scientist explains why COVID-19 targets only some organs while others are spared

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the enzyme angiotensin-converting enzyme 2 (ACE2) to enter and infect human cells. It causes COVID-19 and can lead to a multitude of complications, including multi-organ impairment, partially due to the abundant expression of ACE2 in all human tissues.

11 Aug 2020

Pupil size predicts death and hospital readmission in patients with heart failure

Pupil size predicts death and hospital readmission in patients with heart failure, according to research published today in ESC Heart Failure, a journal of the European Society of Cardiology (ESC).1

11 Aug 2020

Researchers reveal molecular workings of a key system in learning and memory formation

One of the new realities in biomedical research is that it's increasingly difficult to use a general approach to score advances. Now, investigations into disease mechanisms, for example, are often conducted at the molecular level by specialists who dedicate years to interrogating a single protein or signaling pathway.

10 Aug 2020

Real-life discussions may help counter anti-vaccination influences from social media

The flu vaccine is considered one of the great achievements in public health, and each year it prevents millions of people from getting sick and thousands of deaths.

10 Aug 2020

Proteinuria reduction slows kidney decline in patients with focal segmental glomerulosclerosis

Reducing the amount of protein in the urine of patients with focal segmental glomerulosclerosis (FSGS), a rare disease in which scar tissue forms on the parts of the kidneys that filter waste from the blood, can significantly slow declines in kidney function and extend time before patients' kidneys fail, a new analysis by a Children's National Hospital researcher and her colleagues shows.

10 Aug 2020

Non-fasting blood test can help accurately identify youth at risk for diabetes and related risks

A simple blood test that does not require overnight fasting has been found to be an accurate screening tool for identifying youth at risk for type 2 diabetes and heart disease risk later in life, according to a study from researchers at the Johns Hopkins Bloomberg School of Public Health.

10 Aug 2020

Study shows link between high blood lead levels and aberrant methylation of DNA

Scientists have unveiled a correlation between high blood lead levels in children and methylation of genes involved in haem synthesis and carcinogenesis, indicating a previously unknown mechanism for lead poisoning.

7 Aug 2020

USF Health researchers develop new reporter mouse strain for identifying P2X2-expressing cells

Despite frequent news announcing "medical breakthroughs," advancements in biomedical and clinical science typically happen incrementally.

7 Aug 2020

Immunothrombotic dysregulation is key marker of disease severity in COVID-19

In severe cases of COVID-19, the infection can lead to obstruction of the blood vessels in the lung, heart and kidneys. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have now shown that activated immune cells and blood platelets play a major role in these pathologies.

7 Aug 2020

Large-scale analysis of Alport syndrome reveals the effectiveness of existing treatments

A large-scale analysis of the clinical characteristics of Alport syndrome in Japanese patients has revealed that the effectiveness of existing treatment with ACE inhibitors and/or angiotensin receptor blockers (RAS inhibitors) varies depending on the type of mutation in the syndrome's causal gene (COL4A5).

7 Aug 2020

Marshall University researcher awarded NIH grant to study uremic cardiomyopathy

Komal Sodhi, M.D., an associate professor of surgery and biomedical sciences at the Marshall University Joan C. Edwards School of Medicine, has been awarded a $444,000 grant from the National Institutes of Health to further her research on cardiomyopathy associated with chronic renal failure, or uremic cardiomyopathy.

6 Aug 2020

Researchers shed new light on epigenetic changes associated with ADNP syndrome

A study led by the Seaver Autism Center for Research and Treatment at Mount Sinai found that two different blood epigenetic signatures associated with ADNP syndrome (also known as Helsmoortel-Van Der Aa syndrome) have only a modest correlation with clinical manifestations of the syndrome. The study results were published online August 5 in the American Journal of Human Genetics.

6 Aug 2020

Study provides comprehensive update on ACE2 enzyme with key role in SARS-CoV-2 infection

Researchers at Uppsala University have described the presence, throughout the human body, of the enzyme ACE2.

5 Aug 2020

GADL1 enzyme may be linked to athletic performances, shows study

Carnosine and its precursor beta-alanine increases muscle strength, and have recently become extremely popular as dietary supplements in competitive sports.

5 Aug 2020

Gout diagnoses increased dramatically from 1990 to 2017, shows new analysis

The prevalence of gout--a form of arthritis characterized by severe pain, redness, and tenderness in joints--increased across the world at an alarming rate from 1990 to 2017, according to an analysis published in Arthritis & Rheumatology.

5 Aug 2020

Researchers identify novel protein that reduces adverse effect of hypertonicity

A University of Houston College of Medicine researcher has found how a protein inside the body reduces the adverse effects of hypertonicity, an imbalance of water and solutes inside cells. Hypertonicity causes cell shrinkage and eventual cell death.

5 Aug 2020

ACTG initiates novel clinical trial to evaluate multiple therapeutics for COVID-19

The AIDS Clinical Trials Group, the world's largest and longest established HIV research network, today announced the initiation of the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial, which will be conducted by the ACTG.

4 Aug 2020

Specifically designed cyclic peptide inhibitor shown to be active against SARS-CoV-2

A new bioRxiv study by a research group from the University of California Irvine shows in vitro activity and non-toxicity of the first-in-class cyclic peptide that inhibits the main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – laying the groundwork for its use in the treatment of coronavirus disease (COVID-19).

4 Aug 2020

Researchers discover treatment for severe auto inflammatory syndrome

Researchers from the Icahn School of Medicine used a novel genetic sequencing technology to identify the genetic cause of--and a treatment for--a previously unknown severe auto inflam-matory syndrome affecting an 18-year-old girl since infancy.

4 Aug 2020

AI-enabled ECG provides a rapid and effective method to screen heart failure

When people seek emergency care for shortness of breath, a routine electrocardiogram (ECG or EKG) enhanced by artificial intelligence (AI) is better than standard blood tests at determining if the cause is heart failure, according to new research published today in Circulation: Arrhythmia and Electrophysiology, an American Heart Association journal.

4 Aug 2020

Nephrology News and Research

Further Reading

Scientist explains why COVID-19 targets only some organs while others are spared

Pupil size predicts death and hospital readmission in patients with heart failure

Researchers reveal molecular workings of a key system in learning and memory formation

Real-life discussions may help counter anti-vaccination influences from social media

Proteinuria reduction slows kidney decline in patients with focal segmental glomerulosclerosis

Non-fasting blood test can help accurately identify youth at risk for diabetes and related risks

Study shows link between high blood lead levels and aberrant methylation of DNA

USF Health researchers develop new reporter mouse strain for identifying P2X2-expressing cells

Immunothrombotic dysregulation is key marker of disease severity in COVID-19

Large-scale analysis of Alport syndrome reveals the effectiveness of existing treatments

Marshall University researcher awarded NIH grant to study uremic cardiomyopathy

Researchers shed new light on epigenetic changes associated with ADNP syndrome

Study provides comprehensive update on ACE2 enzyme with key role in SARS-CoV-2 infection

GADL1 enzyme may be linked to athletic performances, shows study

Gout diagnoses increased dramatically from 1990 to 2017, shows new analysis

Researchers identify novel protein that reduces adverse effect of hypertonicity

ACTG initiates novel clinical trial to evaluate multiple therapeutics for COVID-19

Specifically designed cyclic peptide inhibitor shown to be active against SARS-CoV-2

Researchers discover treatment for severe auto inflammatory syndrome

AI-enabled ECG provides a rapid and effective method to screen heart failure

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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