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'Methylation clock' gene found to have functional role in aging of the eye

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age.

16 Jan 2020

Study shows superior functionality of Duodenum Intestine-Chip populated with organoids

Emulate, Inc. announced today a published study in collaboration with Johns Hopkins University School of Medicine, that demonstrated superior functionality of the Duodenum Intestine-Chip populated with organoids, compared to organoids alone.

14 Jan 2020

Scientists gain insights into structure and interactions of EGF receptors

Whether a cell grows, divides or dies is controlled among other things by receptors that messenger substances bind to externally.

13 Jan 2020

Discovery of cellular 'hands' could have implications in the fields of cell, developmental biology

The protein, called syndecan-4, combines with fellow cell membrane proteins, called integrins, to form protruding 'hands' that sense the environment outside the cell.

6 Jan 2020

Study provides better understanding of mechanisms that limit cilia number in cells

One of the wonders of cell biology is its symmetry. Mammalian cells have one nucleus and one cell membrane, and most humans have 23 pairs of chromosomes.

30 Dec 2019

Ancestral-sequence reconstruction of FMO genes unveils structure of important enzyme

To disarm toxic substances, many organisms - including humans - possess enzymes called flavin-containing monooxygenases. Despite their importance, the structure of the enzymes has not been resolved, as the protein is too unstable to study in detail.

23 Dec 2019

Scientists identify molecular mechanisms that protect cells against mechanical stress

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified the molecular mechanisms that allow our cells to adapt to, protect themselves against, and survive mechanical stress.

20 Dec 2019

Atomic-level structure of cardiac sodium channel

Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their function, malfunctions, disruption by many disease mutations, and response to medication.

20 Dec 2019

Catastrophic macropinocytosis may aid in cancer treatment

In laboratory experiments, a metabolic inhibitor was able to kill a variety of human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route -- catastrophic macropinocytosis.

18 Dec 2019

Targeting specific nuclear transport systems may lead to possible therapeutic strategies for cancer

Although less often the focus of cancer research, recent studies have hinted at the possible importance of a type of protein known as nuclear transport receptors.

17 Dec 2019

New gene therapy has potential to reverse disease processes

Scientists have developed a new gene-therapy technique by transforming human cells into mass producers of tiny nano-sized particles full of genetic material that has the potential to reverse disease processes.

17 Dec 2019

Researchers examine p53-deficient colon cancer cells to identify how p53 impacts metabolic adaptation

Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to adapt to the lack of oxygen and nutrients inside the tumor. Statins, which are often prescribed to lower cholesterol, block this metabolic pathway and cause the cancer cells to die, as scientists from the German Cancer Research Center have now discovered.

12 Dec 2019

'Achilles' heel' of deadly superbug identified

A deadly superbug that infects an estimated 54,500 Americans a year has a secret weapon, a protein, that allows it to defy antibiotic treatment and immune system attacks.

9 Dec 2019

Nanosize container can slip inside cells and deliver medicines, gene therapies

Scientists at Johns Hopkins Medicine report they have created a tiny, nanosize container that can slip inside cells and deliver protein-based medicines and gene therapies of any size -; even hefty ones attached to the gene-editing tool called CRISPR.

6 Dec 2019

Study provides new insight into learning mechanisms of the cerebellum

In mere milliseconds trillions of chemical reactions ignite signals that travel across the billions of neurons in our brain. As we go through our daily lives and absorb new knowledge these neurons begin to modify themselves and change their signaling properties.

6 Dec 2019

Molecular makeup of abnormal proteins in brain diseases shows structural diversity

Parkinson's and multisystem atrophy - both of them neurodegenerative diseases - are associated with the accumulation of alpha-synuclein proteins in the brain.

4 Dec 2019

New findings regarding maintenance and functioning of the endosome

On a daily basis, multitudes of molecules enter each cell in our body. These can be nutrients or signal molecules or pathogenic microorganisms. An organelle in the cell directs these molecules to other stations for further processing.

3 Dec 2019

Small molecule can induce self-destruction of pancreatic cancer cells, study finds

Pancreatic cancer is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosed.

2 Dec 2019

Leaky gut and space flight – the mechanism revealed

A new study on the effects of simulated microgravity, the condition that astronauts face in space, interferes with the epithelial barrier of the intestine, and the effect persists even after the astronaut returns to a normal environment. The research is published in the journal Scientific Reports.

28 Nov 2019

Obese teenagers at risk for brain damage, suggests new study

A new study being presented at the yearly conference of the Radiological Society of North America (RSNA) reports that MRI scanning of the brain shows signs of brain damage in obese adolescents – and that these signs could be the result of brain inflammation.

25 Nov 2019