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An investigation of three SARS-CoV-2 mRNA doses in multiple sclerosis vaccine non-responders

A clinical study by a team of scientists from Norway aimed to assess the immunogenicity and safety of a third dose of COVID-19 mRNA vaccine in MS patients treated with anti-CD20 therapy or fingolimod. A preprint version of the study, which is yet to undergo peer review, is available on the medRxiv* server.

20 Oct 2021

New technology streamlines the development of gene therapy for genetic blinding disorders

A novel computational platform developed by researchers from the University of Pittsburgh School of Medicine identifies top-performing viral vectors that could deliver gene therapies to the retina with maximum efficiency and precision.

19 Oct 2021

COVID-19 vaccine breakthrough infections among immunocompromised individuals

A study of breakthrough infections in immunocompromised people following two doses of the Pfizer/BioNTech vaccine against SARS-CoV-2 concluded that immunocompromised people would be best served with a third dose of the vaccine for better protection.

19 Oct 2021

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

A new study discusses risk factors for the failure of seroconversion following full vaccination with the COVID-19 Pfizer vaccine.

18 Oct 2021

Researchers report long-lasting effects of gene therapy in children with deadly immune disorder

Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder.

18 Oct 2021

Engineered 3D scaffolds of human brown adipose tissue as a new therapeutic strategy for obesity and diabetes

A group of researchers from various institutes in the USA addressed the limitations of BAT therapy by transplanting a low dose of brown adipocytes (BAs) without Matrigel to determine if this could alleviate high-fat diet-induced OB, metabolic symptoms, and T2DM in mice.

18 Oct 2021

New protocol reduces hospitalizations, deaths of liver and kidney transplant patients with COVID-19

Liver and kidney transplant recipients have a higher risk of severe COVID-19 and/or death should they become infected because the medication they take to ensure a successful transplant suppresses their immune systems.

15 Oct 2021

KHN’s ‘What the Health?’: The politics of vaccine mandates

Should covid vaccines be mandated? The answer to that question has become predictably partisan, as with almost everything else associated with the pandemic.

14 Oct 2021

Study shows how tissue-derived T cells can damage other organs in stem cell transplant patients

More than 40,000 allogeneic hematopoietic stem cell transplants are carried out worldwide every year, mostly for patients suffering from leukemia or other diseases of the hematopoietic system.

13 Oct 2021

COVID-19 vaccination induces transient increase in cellular and antibody responses to S1 antigenic sequence

Scientists have characterized T-cell, B-cell, and IgG responses to S antigenic sequences to evaluate vaccine effectiveness.

13 Oct 2021

New source of stem cells could help treat people with Alagille syndrome

Researchers from Sanford Burnham Prebys have discovered a new source of stem cells just outside the liver that could help treat people living with Alagille syndrome, a rare, incurable genetic disorder in which the bile ducts of the liver are absent, leading to severe liver damage and death.

12 Oct 2021

6 months to live or die: How long should an alcoholic liver disease patient wait for a transplant?

The night before Brian Gorzney planned to check into rehab for alcohol use, he began vomiting blood. First at 2 a.m. Then 5. And again at 11.

12 Oct 2021

Drug developed at Duke is approved by FDA as only therapy for congenital athymia

The phone rang into the pediatric unit that Louise Markert, M.D., Ph.D., was staffing as a junior faculty member in 1991. Had she not answered, there would have been little hope for the more than one hundred patients who were subsequently treated.

11 Oct 2021

Small set of beneficial bacterial strains linked to effectiveness of fecal microbiota transplants

The effectiveness of fecal microbiota transplantation (FMT) in treating ulcerative colitis depends on a small set of beneficial bacterial strains, suggests a new study from researchers at Weill Cornell Medicine and NewYork-Presbyterian.

11 Oct 2021

Better clinical outcomes in COVID-19 and vaccine-related myocarditis than classic myocarditis in children

Researchers have investigated the differences between 'classic' myocarditis, COVID-19 induced myocarditis, and vaccine-related myocarditis.

11 Oct 2021

Kidney transplant patients are more susceptible to harmless bacterium, finds study

It's a pervasive bacterium found in soil and water that rarely causes disease, but a new national review of nocardia infection in people who have had a kidney transplant shows that when it occurs it most commonly causes pneumonia and brain abscess, and reminds their physicians to stay on the lookout for it, investigators say

11 Oct 2021

Organ centers to transplant patients: Get a covid shot or move down on waitlist

A Colorado kidney transplant candidate who was bumped to inactive status for failing to get a covid-19 vaccine has become the most public example of an argument roiling the nation's more than 250 organ transplant centers.

8 Oct 2021

New approach to guided nerve repair by using gingiva-derived mesenchymal stem cells

A new approach to repairing peripheral nerves marries the regenerating power of gingiva-derived mesenchymal stem cells with a biological scaffold to enable the functional recovery of nerves following a facial injury, according to a study by a cross-disciplinary team from the University of Pennsylvania School of Dental Medicine and Perelman School of Medicine.

8 Oct 2021

Study identifies cells that may play a pivotal role in fibrotic scarring after lung transplant

A lung transplant can mean the difference between life and death for people with diseases such as pulmonary fibrosis, chronic obstructive pulmonary disease (COPD) and even severe COVID-19.

8 Oct 2021

Teen’s mysterious condition spurs the opening of Childhood Interstitial Lung Disease Clinic

Thirteen-year-old Gregory Rhoden's condition has been a mystery his entire life. He was born prematurely and his lungs seemed underdeveloped.

7 Oct 2021

Transplant News and Research

An investigation of three SARS-CoV-2 mRNA doses in multiple sclerosis vaccine non-responders

New technology streamlines the development of gene therapy for genetic blinding disorders

COVID-19 vaccine breakthrough infections among immunocompromised individuals

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

Researchers report long-lasting effects of gene therapy in children with deadly immune disorder

Engineered 3D scaffolds of human brown adipose tissue as a new therapeutic strategy for obesity and diabetes

New protocol reduces hospitalizations, deaths of liver and kidney transplant patients with COVID-19

KHN’s ‘What the Health?’: The politics of vaccine mandates

Study shows how tissue-derived T cells can damage other organs in stem cell transplant patients

COVID-19 vaccination induces transient increase in cellular and antibody responses to S1 antigenic sequence

New source of stem cells could help treat people with Alagille syndrome

6 months to live or die: How long should an alcoholic liver disease patient wait for a transplant?

Drug developed at Duke is approved by FDA as only therapy for congenital athymia

Small set of beneficial bacterial strains linked to effectiveness of fecal microbiota transplants

Better clinical outcomes in COVID-19 and vaccine-related myocarditis than classic myocarditis in children

Kidney transplant patients are more susceptible to harmless bacterium, finds study

Organ centers to transplant patients: Get a covid shot or move down on waitlist

New approach to guided nerve repair by using gingiva-derived mesenchymal stem cells

Study identifies cells that may play a pivotal role in fibrotic scarring after lung transplant

Teen’s mysterious condition spurs the opening of Childhood Interstitial Lung Disease Clinic

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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