Chromosome 4 News and Research

RSS

Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 4, one copy inherited from each parent, form one of the pairs. Chromosome 4 spans more than 191 million DNA building blocks (base pairs) and represents more than 6 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 4 likely contains between 1,300 and 1,600 genes.

Genes on chromosome 4 are among the estimated 20,000 to 25,000 total genes in the human genome.

Einstein researcher receives $7.5 million NIH grant to study genetics of congenital heart disease

The National Institutes of Health has awarded Bernice Morrow, Ph.D., at Albert Einstein College of Medicine and collaborators at the Children's Hospital of Philadelphia a five-year, $7.5 million grant to study the genetics of congenital heart abnormalities.

22 Nov 2016

Study offers genetic explanation why cancer occurs commonly in males than females

In a new study, a group of Boston scientists, including researchers at Dana-Farber Cancer Institute, offer a genetic explanation for the age-old conundrum of why cancer is more common in males than females.

22 Nov 2016

Researchers create new Zika replicon system to find ways to combat virus

New research from The University of Texas Medical Branch in Galveston, in collaboration with Southwest University in Chongqing, China and the University of Leuven in Belgium, have developed a way to replicate the basic structure of the Zika virus, stripping it of the genes that make the virus infectious.

18 Nov 2016

Veterans Affairs researchers discover alleles of certain genes that offer protection from GWI

Veterans Affairs researchers have found that certain forms, or alleles, of a gene known to play a key role in the immune system appear to offer protection from Gulf War illness (GWI). Further, they discovered how such protection is manifested in the brain.

17 Nov 2016

Researchers create first mouse model for common form of infant leukemia

After nearly two decades of unsuccessful attempts, researchers from the University of Chicago Medicine and the Cincinnati Children's Hospital Medical Center have created the first mouse model for the most common form of infant leukemia.

15 Nov 2016

Length of telomeres may reveal if vitamin D and omega-3 supplements improve heart health, longevity

The length of your telomeres appears to be a window into your heart health and longevity, and scientists are measuring them to see if vitamin D and omega-3 supplements really improve both.

14 Nov 2016

UPCI scientists reveal how cancer cells hijack DNA repair pathways to stay alive

Research by scientists at the University of Pittsburgh Cancer Institute has revealed how cancer cells hijack DNA repair pathways to prevent telomeres, the endcaps of chromosomes, from shortening, thus allowing the tumor to spread. The findings are published today in the journal Cell Reports.

8 Nov 2016

UNC scientists find clue that may help explain why people differ in ability to survive arterial blockages

Researchers at the University of North Carolina School of Medicine have found a major clue that may explain why some people sustain relatively little damage from strokes or heart attacks despite severe arterial blockages.

7 Nov 2016

IU scientists find evidence for link between prostate cancer and Ewing's sarcoma

Medical researchers at Indiana University Bloomington have found evidence for a link between prostate cancer, which affects millions of men age 50 and older, and Ewing's sarcoma, a rare form of cancer that affects children and young adults.

25 Oct 2016

Small RNA molecules could contribute to serious pregnancy complication, study finds

A family of small RNA molecules affects the development of cells that give rise to the placenta - an organ that transfers oxygen and nutrients from mother to fetus -- in ways that could contribute to a serious pregnancy complication, UT Southwestern Medical Center researchers report.

24 Oct 2016

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Researchers at St. Jude Children's Research Hospital have discovered the way toxic proteins linked to the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) incapacitate membrane-less organelles inside cells.

21 Oct 2016

Researchers identify genomic regions linked to ulcerative colitis in African-Americans

In the first genome-wide association study of genetic risk factors for inflammatory bowel disease in African Americans, a research team has identified two regions of the genome (loci) associated with ulcerative colitis only in people of African descent.

20 Oct 2016

Gene variants linked to hot flashes in menopausal women

Most women experience hot flashes and night sweats either before or during menopause, but a significant minority don't have these symptoms. Could our genes be a factor in determining which women get hot flashes?

19 Oct 2016

Study shows how oxidative damage may contribute to ‘maternal age effect’

For women in their 30s and beyond, the probability of a pregnancy that results in a miscarriage or a Down syndrome pregnancy is staggering with the risk increasing to 1 in 3 by the time a woman reaches her early 40s due to the "maternal age effect," the high incidence of mistakes in chromosome segregation that occur during the cell division process of meiosis, which gives rise to the egg.

19 Oct 2016

Network of proteins linked to cancer may play vital role in male fertility

Researchers studying reproductive science identified a network of proteins often linked to cancer as also important to male fertility and the birth of healthy offspring, according to a study in the Oct. 18 online issue of Cell Reports.

19 Oct 2016

OGT announces expansion of Cytocell Aquarius Haematology FISH probe range

Oxford Gene Technology, The Molecular Genetics Company, has today announced a significant expansion of its existing catalogue of Cytocell Aquarius Haematology probes for fluorescence in situ hybridisation (FISH) — underlining the company's position as the one-stop-shop for high-quality FISH probes.

13 Oct 2016

Researchers discover gene region that raises risk of middle ear infections in children

Researchers have discovered a gene region that raises the risk a child will have a middle ear infection, known to doctors as acute otitis media (AOM)—and known to parents as one reason for a screaming, unhappy preschooler.

4 Oct 2016

Researchers move one step closer to unraveling mechanism of multiple-gene disorder

Scientists at Johns Hopkins say they are one step closer to understanding the genetic mechanism of a rare, complex, multiple-gene disorder called Hirschsprung's disease.

30 Sep 2016

Researchers link RHOX gene mutations to infertility in men

The underlying cause of male infertility is unknown for 30 percent of cases. In a pair of new studies, researchers at University of California San Diego School of Medicine determined that the reproductive homeobox (RHOX) family of transcription factors — regulatory proteins that activate some genes and inactivate others — drive the development of stem cells in the testes in mice.

27 Sep 2016

New project clarifies molecular processes involved in hidden HIV reservoir

In spite of ever more effective therapies, HIV keeps managing to survive in the body. A comprehensive project conducted by the Austrian Science Fund FWF has clarified the molecular processes which contribute to this effect.

27 Sep 2016

Chromosome 4 News and Research

Further Reading

Einstein researcher receives $7.5 million NIH grant to study genetics of congenital heart disease

Study offers genetic explanation why cancer occurs commonly in males than females

Researchers create new Zika replicon system to find ways to combat virus

Veterans Affairs researchers discover alleles of certain genes that offer protection from GWI

Researchers create first mouse model for common form of infant leukemia

Length of telomeres may reveal if vitamin D and omega-3 supplements improve heart health, longevity

UPCI scientists reveal how cancer cells hijack DNA repair pathways to stay alive

UNC scientists find clue that may help explain why people differ in ability to survive arterial blockages

IU scientists find evidence for link between prostate cancer and Ewing's sarcoma

Small RNA molecules could contribute to serious pregnancy complication, study finds

Researchers discover how toxic proteins linked to neurological diseases impair membrane-less organelles

Researchers identify genomic regions linked to ulcerative colitis in African-Americans

Gene variants linked to hot flashes in menopausal women

Study shows how oxidative damage may contribute to ‘maternal age effect’

Network of proteins linked to cancer may play vital role in male fertility

OGT announces expansion of Cytocell Aquarius Haematology FISH probe range

Researchers discover gene region that raises risk of middle ear infections in children

Researchers move one step closer to unraveling mechanism of multiple-gene disorder

Researchers link RHOX gene mutations to infertility in men

New project clarifies molecular processes involved in hidden HIV reservoir

Shaping the Future of Neuroscience: A Conversation with Atlas Antibodies on the MolBoolean™ and the Impact of SfN 2024

How the Arts Reshape Brain Function: Susan Magsamen on the Future of Neuroaesthetics

Inside the Alzheimer's Association: Dr. Heather Snyder on Driving Research and Collaboration

Latest News