Small Molecules News and Research

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Researchers create molecules with potential to deliver healing power to stressed cells

Molecules with the potential to deliver healing power to stressed cells - such as those involved in heart attacks - have been created by University of Oregon researchers.

30 Dec 2016

Nexmos, Base Pair Biotechnologies create new class of DNA-aptamer based oxidation inhibitors

Base Pair Biotechnologies, Inc., The Aptamer Discovery Company, and Nexmos, Inc., the Aptamer Application R&D Company, announce the creation of a new class of DNA-aptamer based oxidation inhibitors.

30 Dec 2016

Potential drug could become first effective treatment option for Prader-Willi syndrome

Duke Health researchers have identified a drug-like small molecule that, in animal experiments, appears to be an effective treatment for a genetic disorder called Prader-Willi syndrome.

27 Dec 2016

Princeton researchers employ light to activate new reactivity in existing enzymes

Enzymes are nature's tools for catalyzing life's essential reactions. Though unrivaled in their efficiency and selectivity, enzymes only carry out a narrow range of natural reactions, limiting their usefulness in modern organic synthesis.

21 Dec 2016

TSRI scientists develop new methods to design precision medicines against disease-causing RNAs

Scientists on the Florida campus of The Scripps Research Institute have developed broad methods to design precision medicines against currently incurable diseases caused by RNA.

20 Dec 2016

Researchers receive NIH grant to map molecular changes linked to physical movement

A research team led by Robert Gerszten, MD, Chief of Cardiovascular Medicine at Beth Israel Deaconess Medical Center and a Senior Associate Member of the Broad Institute, has received an award of more than $11 million as part of the Molecular Transducers of Physical Activity in Humans consortium, a large-scale initiative of the National Institutes of Health to investigate and map the molecular changes that occur in our bodies during and after exercise.

17 Dec 2016

Researchers develop promising therapeutic antibodies against tumor-promoting MMPs

Researchers at the University of California, Riverside have camels and llamas to thank for their development of a new cancer treatment that is highly selective in blocking the action of faulty matrix metalloproteinases (MMPs).

16 Dec 2016

Scientists discover truncated p53 proteins that promote cancer growth and metastasis

Discovered in the 1970s, tumor suppressors are among the most important proteins in the body.

8 Dec 2016

Biochemists uncover how potential diabetes drugs interact with LRH-1 protein

Imagine a key that opens a pin tumbler lock. A very similar key can also fit into the lock, but upside down in comparison to the first key.

6 Dec 2016

Type 2 diabetes drug may someday help combat breast and ovarian cancers

A drug used now to treat Type 2 diabetes may someday help beat breast and ovarian cancers, but not until researchers decode the complex interactions that in some cases help promote tumors, according to Rice University scientists.

30 Nov 2016

Scientists synthesize antitumor compound to combat chemoresistant cancer

A team of scientists from N. D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, N. K. Kol'tsov Institute of Developmental Biology of the RAS, and Immune Pharmaceuticals LLC led by MIPT's Prof. Alexander Kiselyov has synthesized an antitumor compound that could be used to fight chemoresistant cancer.

30 Nov 2016

Dirt beneath New York City may provide new weapons to fight against disease

Microbes have long been an invaluable source of new drugs. And to find more, we may have to look no further than the ground beneath our feet.

29 Nov 2016

New approach could revolutionize manufacturing of single-crystal printed electronics

Has the time come to replace traditionally used silicon with printable organic semiconductor inks? University of Surrey scientists believe so, especially for future electronics that need to be flexible, lightweight, wearable and low-cost.

23 Nov 2016

Researchers identify protein that plays key role in LDL accumulation in blood vessels

A Yale-led research team identified a protein that plays an important role in the buildup of LDL cholesterol in blood vessels.

21 Nov 2016

De-risking drug development free webinar from Envigo

De-risking represents a relatively new but developing strategy designed to quickly assess if a new drug has a liability. Knowing your compound’s risk for drug-to-drug interactions (DDI), drug induced liver injury (DILI) and metabolites in safety testing (MIST) early on in drug development, leads to greater confidence and added value on your molecule’s journey to market.

18 Nov 2016

Scientists examine new class of small molecules with potential to improve cryopreservation

Freezing and reanimating your body is still science fiction, but cryopreserving cells and certain tissues for future use is a reality.

17 Nov 2016

BUSM researchers discover new pathway and protein involved in metastasis of breast cancer

Researchers have identified a new pathway and with it a protein, BRD4, necessary for breast cancer cells to spread.

15 Nov 2016

Researchers find new therapeutic target of biomedical interest in ischemic injury research

An international scientific team has developed a new small molecule -VH298- which can provoke a hypoxic response controlled from outside the cells, according to a study recently published in the magazine Nature Communications with its first authors being the expert Carles Galdeano, Beatriu de Pinós researcher at the Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry of the Faculty of Pharmacy and Food Sciences and the Institute of Biomedicine of the University of Barcelona, and Julianty Frost, from the University of Dundee.

15 Nov 2016

Research shows workings of biochemical pathway that helps control blood glucose

Research led by a Johns Hopkins University biologist demonstrates the workings of a biochemical pathway that helps control glucose in the bloodstream, a development that could potentially lead to treatments for diabetes.

14 Nov 2016

Biochemists create first atlas of DNA-binding molecules for use in precision medicine

Biochemists at the University of Wisconsin-Madison have created the first atlas that maps where molecular tools that can switch genes on and off will bind to the human genome.

8 Nov 2016