Metformin News and Research

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Metformin is the active ingredient in a drug used to treat diabetes mellitus (a condition in which the body cannot control the level of sugar in the blood). It is also being studied in the treatment of cancer. It decreases the amount of glucose (a type of sugar) released into the bloodstream from the liver and increases the body’s use of the glucose. Metformin is a type of antidiabetic agent.

More fractures, less bone density in premenopausal women with diabetes

Premenopausal women who have type 1 diabetes should strongly consider preventive screening for osteoporosis, the researchers of a new study on bone density conclude in the February issue of Diabetes Care.

27 Jan 2006

Actos reduces the combined risk of non-fatal heart attacks, strokes in patients with type-2 diabetes

A study published in The Lancet shows that Takeda's Actos (pioglitazone HCl), an oral glucose lowering medication, significantly reduces the combined risk of non-fatal heart attacks, strokes and deaths by an additional 16% on top of standard medication

10 Oct 2005

Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in children

The Nonalcoholic Steatohepatitis (NASH) Clinical Research Network has launched its second clinical trial to study NASH, a liver disease that resembles alcoholic liver disease but occurs in patients who drink little or no alcohol. The first trial, launched in January of this year, focuses on adults, while the second trial studies the disease in children.

27 Sep 2005

Oral medications may control symptoms of Type II diabetes in children just as well as insulin injections

According to the medical records of 26 children diagnosed with the disease, oral medications reduced levels of a compound in the blood called hemoglobin A1C by an average of 2 percentage points.

15 Aug 2005

Ranbaxy receives tentative approval to manufacture and market Glimepiride tablets

Indian drug manufacturer, Ranbaxy Pharmaceuticals has tentative approval from the U.S. Food and Drug Administration to manufacture and market Glimepiride Tablets, 3 mg and 6 mg.

28 Jul 2005

Metformin should be in the first line of defense against type 2 diabetes

A new review of studies confirms that the drug metformin should be in the first line of defense against type 2 diabetes. Using metformin alone can improve control of blood glucose, while also reducing risk factors for heart disease such as excess body weight, cholesterol levels and hypertension, the review found.

20 Jul 2005

Takeda Pharmaceuticals submits NDA for a new oral diabetes medication

Takeda Pharmaceuticals North America today announced that the company has submitted a New Drug Application (NDA) for a new oral medication that combines pioglitazone HCl and glimepiride, a sulfonylurea, to the United States Food and Drug Administration (FDA) for the treatment of type 2 diabetes.

30 Jun 2005

Scientists have discovered how C-reactive protein is able to access endothelial cells

For the first time, scientists have discovered how C-reactive protein, or CRP, is able to access endothelial cells. The UC Davis researchers' findings will be published in the July issue of Arteriosclerosis, Thrombosis, and Vascular Biology, one of the American Heart Association's leading journals.

27 Jun 2005

GlaxoSmithKline announces availability of Paxil CR to U.S. market

GlaxoSmithKline announced today the availability of Paxil CR (paroxetine hydrochloride controlled release) tablets in pharmacies across the United States. Other markets will follow shortly thereafter.

27 Jun 2005

Rimonabant study shows significant improvements in HbA1c and cardiometabolic risk factors in people with type 2 diabetes

The reported results of a one-year phase III study in 1045 people with type 2 diabetes treated with rimonabant, the first in a new class of therapeutic agents called selective CB1 Blockers, were that rimonabant 20 mg significantly improved HbA1c (a measure of blood sugar control), dyslipidemia (abnormal levels of fat in the blood), and systolic blood pressure with a concomitant substantial reduction in abdominal obesity in people with type 2 diabetes treated with oral anti-diabetic medications and requiring further control.

12 Jun 2005

Muraglitazar lowers blood glucose and helps dyslipidemia seen in diabetes

A novel compound provides long-term lowering of blood glucose levels and improves plasma lipids (fats) that are often a problem in people with type 2 diabetes -- all in a once-daily pill, according to a report presented today at the American Diabetes Association's 65th Annual Scientific Sessions.

12 Jun 2005

Patients with newly diagnosed type 2 diabetes should be screened for retinopathy

Diabetic retinopathy has been found in nearly 8 percent of pre-diabetic participants in the Diabetes Prevention Program (DPP), according to a report presented today at the American Diabetes Association's 65th Annual Scientific Sessions.

12 Jun 2005

Allergies may be linked to irregular periods

New research is suggesting a there is possibly a link between allergic conditions such as asthma and hay fever and irregular periods.

29 May 2005

Could diabetes drug prevent cancer?

A well known drug which is commonly used to treat Type 2 diabetes may prevent cancer tumours, according to researchers at the University of Dundee.

23 Apr 2005

New trial for treatment of liver disease

The Nonalcoholic Steatohepatitis (NASH) Clinical Research Network is launching its first two clinical trials for the study of NASH, a liver disease that resembles alcoholic liver disease but occurs in patients who drink little or no alcohol.

3 Apr 2005

Proteins link cellular aging and response to calorie restriction

In the March 3 issue of Nature, Johns Hopkins researchers report that two proteins best known for very different activities actually come together to turn the liver into a sugar-producing factory when food is scarce.

6 Mar 2005

Future diabetes drugs may target new protein interaction

2 Mar 2005

First study to show cost-effectiveness of pre-diabetes intervention

More than 40 million Americans face a high risk of developing Type 2 diabetes, and it would cost a lot to give all of them intensive help with diet and exercise, or medication, to keep them from developing diabetes.

28 Feb 2005

Insulin sensitizing drugs help thin women as well overweight women with polycystic ovary syndrome

Insulin-sensitizing drugs can help thin women with polycystic ovary syndrome even if they do not appear to be insulin resistant, broadening the range of women who can benefit from the therapy, a Virginia Commonwealth University researcher said in this month’s issue of the journal Fertility and Sterility.

16 Oct 2004

Exubera shows sustained blood glucose control in patients with type 2 diabetes

New data showed that Exubera (inhaled insulin) was effective and well tolerated in controlling blood glucose levels over a two-year period in patients with Type 2 diabetes.

8 Sep 2004

Metformin News and Research

Further Reading

More fractures, less bone density in premenopausal women with diabetes

Actos reduces the combined risk of non-fatal heart attacks, strokes in patients with type-2 diabetes

Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) in children

Oral medications may control symptoms of Type II diabetes in children just as well as insulin injections

Ranbaxy receives tentative approval to manufacture and market Glimepiride tablets

Metformin should be in the first line of defense against type 2 diabetes

Takeda Pharmaceuticals submits NDA for a new oral diabetes medication

Scientists have discovered how C-reactive protein is able to access endothelial cells

GlaxoSmithKline announces availability of Paxil CR to U.S. market

Rimonabant study shows significant improvements in HbA1c and cardiometabolic risk factors in people with type 2 diabetes

Muraglitazar lowers blood glucose and helps dyslipidemia seen in diabetes

Patients with newly diagnosed type 2 diabetes should be screened for retinopathy

Allergies may be linked to irregular periods

Could diabetes drug prevent cancer?

New trial for treatment of liver disease

Proteins link cellular aging and response to calorie restriction

Future diabetes drugs may target new protein interaction

First study to show cost-effectiveness of pre-diabetes intervention

Insulin sensitizing drugs help thin women as well overweight women with polycystic ovary syndrome

Exubera shows sustained blood glucose control in patients with type 2 diabetes

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