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New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

An investigational vaccine designed to protect against the B.1.351 SARS-CoV-2 variant has been administered as part of a new Phase 1 clinical trial evaluating the vaccine candidate's safety and immunogenicity in adult volunteers.

31 Mar 2021

New portable viral screening test can diagnose COVID-19 in minutes and track variants

Clinicians using a new viral screening test can not only diagnose COVID-19 in a matter of minutes with a portable, pocket-sized machine, but can also simultaneously test for other viruses--like influenza--that might be mistaken for the coronavirus.

31 Mar 2021

Study details COVID-19 risk factors among long-stay nursing home residents in the U.S.

Risks of SARS-CoV-2 coronavirus infection for long-stay nursing home residents were mainly dependent on factors in their nursing homes and surrounding communities, according to a large study led by a researcher at the Johns Hopkins Bloomberg School of Public Health.

31 Mar 2021

Tamper-proof temperature indicator could help monitor ideal storage conditions of mRNA vaccines

Scientists have developed vaccines for COVID-19 with record speed. The first two vaccines widely distributed in the U.S. are mRNA-based and require ultracold storage (-70 C for one and -20 C for the other).

31 Mar 2021

B.1.1.7 rapidly becoming the dominant SARS-CoV-2 variant in the United States

The faster-spreading B.1.1.7 variant of SARS-CoV-2 first detected in the United Kingdom, the coronavirus that causes COVID-19, is quickly on its way to becoming the dominant variant of the virus in the United States, according to a study from scientists at Scripps Research and the COVID-19 test maker Helix.

31 Mar 2021

New mRNA COVID-19 vaccine candidate shows promise in vivo

Researchers report that a new lipid nanoparticle mRNA coronavirus disease 2019 (COVID-19) vaccine candidate protected 70% of mice expressing the human angiotensin-converting enzyme 2 (ACE2), while all the non-vaccinated mice died.

31 Mar 2021

Are marine mammals are at risk of COVID-19?

Researchers have identified a number of marine mammal species native to Italian seawaters that may be highly susceptible to the disease. Additionally, these species inhabit ocean areas where the virus may be present even after receiving sewage treatment, thus highlighting the need for strict sewage improvement plans.

31 Mar 2021

Researchers evaluate antibodies that inhibit SARS-CoV-2 RBD variants with a novel assay

A team of researchers recently discussed the potential role of a new assay in bridging a major gap in SARS-CoV-2 research. This assay can throw light on 1) the selection of complementary monoclonal antibody candidates and 2) rapid identification of the immune escape to emerging RBD variants following vaccination or natural infection.

31 Mar 2021

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

The ongoing COVID-19 pandemic, caused by SARS-CoV-2, is now established to be more likely to lead to symptomatic and serious illness in males relative to females. This may extend as far back as pregnancy, suggests a recent study.

31 Mar 2021

Obesity and ethnicity identified as key risk factors for SARS-CoV-2 exposure in UK

The risk factors for severe COVID-19 have been established on the basis of observational studies. However, SARS-CoV-2 continues to cause thousands of COVID-19 cases all over the world, and the risk factors are unclear. A new study deals with this aspect of the pandemic.

31 Mar 2021

Infliximab may hinder the effectiveness of some COVID-19 vaccines

A new study reports reduced vaccine efficacy following the use of a single COVID-19 vaccine dose in people who are on the immunosuppressive monoclonal antibody Infliximab.

31 Mar 2021

Asymmetrical vaccine distribution could promote vaccine evading mutations in SARS-CoV-2

Researchers have investigated the ultimate influence of unequal vaccine distribution by mathematical modeling, revealing the critical role of fair distribution in future COVID-19 containment strategy.

31 Mar 2021

SARS-CoV-2 inhibits the cellular response to interferon

Researchers have explored the effect of SARS-CoV-2 infection on the function of RIG-I and MDA5, and ultimately on interferon production.

31 Mar 2021

Widely available drug reduces morbidity, mortality in COVID-19-infected mice

Mount Sinai researchers have found that a widely available and inexpensive drug targeting inflammatory genes has reduced morbidity and mortality in mice infected with SARS-CoV-2, the virus that causes COVID-19.

31 Mar 2021

Soft X-ray microscopy shows how viral pathogens penetrate human cells

How do viral pathogens succeed in penetrating human cells? Which cellular mechanisms do they use to multiply efficiently and, in doing so, how do they change the structure of their host cell? These questions are the focus of a pan-European research project called "Compact Cell-Imaging Device" (CoCID), in which Heidelberg scientists are playing a major role.

31 Mar 2021

NIAID researchers identify key player in the immune response to SARS-CoV-2

When variants of SARS-CoV-2 (the virus that causes COVID-19) emerged in late 2020, concern arose that they might elude protective immune responses generated by prior infection or vaccination, potentially making re-infection more likely or vaccination less effective.

31 Mar 2021

Study shows how viral distribution of SARS-CoV-2 in the human body relates to tissue damage

Researchers have mapped the distribution of SARS-CoV-2, the virus that causes COVID-19, in deceased patients with the disease, and shed new light on how viral load relates to tissue damage.

31 Mar 2021

Researchers analyze how in-person learning would impact transmission in schools' communities

Since early in the COVID-19 pandemic, parents, teachers, and school administrators have faced difficult questions regarding when and how to safely reopen for in-person learning.

31 Mar 2021

Scientists receive NIH grant to monitor COVID-19 in wastewater

Everyone poops, and now scientists are using this bodily function to develop a detailed analysis of the virus that causes COVID-19, known as SARS-CoV-2.

31 Mar 2021

Development of a model of substrate coordination to Zn-bound ACE2

The ongoing coronavirus disease-19 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has claimed more than 2.8 million lives worldwide. Authorities are facing difficulty in preventing the spread of disease due to the highly infectious nature of SARS-CoV-2. Therefore, reducing the virus's ability to infect an individual's respiratory epithelial cells could prove an effective measure to prevent disease transmission.

31 Mar 2021

SARS News and Research

New Phase 1 clinical trial of investigational vaccine against B.1.351 SARS-CoV-2 variant begins

New portable viral screening test can diagnose COVID-19 in minutes and track variants

Study details COVID-19 risk factors among long-stay nursing home residents in the U.S.

Tamper-proof temperature indicator could help monitor ideal storage conditions of mRNA vaccines

B.1.1.7 rapidly becoming the dominant SARS-CoV-2 variant in the United States

New mRNA COVID-19 vaccine candidate shows promise in vivo

Are marine mammals are at risk of COVID-19?

Researchers evaluate antibodies that inhibit SARS-CoV-2 RBD variants with a novel assay

Male fetuses impair the maternal and placental immune response to SARS-CoV-2 infection in pregnancy, finds study

Obesity and ethnicity identified as key risk factors for SARS-CoV-2 exposure in UK

Infliximab may hinder the effectiveness of some COVID-19 vaccines

Asymmetrical vaccine distribution could promote vaccine evading mutations in SARS-CoV-2

SARS-CoV-2 inhibits the cellular response to interferon

Widely available drug reduces morbidity, mortality in COVID-19-infected mice

Soft X-ray microscopy shows how viral pathogens penetrate human cells

NIAID researchers identify key player in the immune response to SARS-CoV-2

Study shows how viral distribution of SARS-CoV-2 in the human body relates to tissue damage

Researchers analyze how in-person learning would impact transmission in schools' communities

Scientists receive NIH grant to monitor COVID-19 in wastewater

Development of a model of substrate coordination to Zn-bound ACE2

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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