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TSRI study reveals new approach to intervene in deadly disease

In a new study, scientists at The Scripps Research Institute have identified drug candidates that can boost a cell's ability to catch the "typos" in protein production that can cause a deadly disease called amyloidosis.

From Paxman 21 Jul 2016

Scientists create new cell-membrane-like material with potential for water purification and drug delivery

Materials scientists have created a new material that performs like a cell membrane found in nature. Such a material has long been sought for applications as varied as water purification and drug delivery.

20 Jul 2016

Study shows how dietary restriction impacts autophagy in intestine to increase lifespan

Dietary restriction, or limited food intake without malnutrition, has beneficial effects on longevity in many species, including humans. A new study from the Sanford Burnham Prebys Medical Discovery Institute (SBP), published today in PLoS Genetics, represents a major advance in understanding how dietary restriction leads to these advantages.

15 Jul 2016

Scientists reveal how manipulating novel target in the brain could lead to new therapies for depression

Northwestern Medicine scientists have shown how manipulating a novel target in the brain using gene therapy could lead to new treatments for depression.

12 Jul 2016

Researchers identify potential biomarkers predictive of TKIs response in metastatic renal cancer

A team of CNIO researchers, in collaboration with the Spanish Oncology Genitourinary Group and the University Hospitals Leuven, has discovered various potential biomarkers predictive of tyrosine kinase inhibitors (TKIs) response in metastatic renal cancer.

8 Jul 2016

Experts discuss potential of DNA origami

Ten years after its introduction, DNA origami, a fast and simple way to assemble DNA into potentially useful structures, is finally coming into its own.

7 Jul 2016

Whole-genome omics data can improve accuracy of breast cancer survival predictions

Precise predictions of whether a tumor is likely to spread would help clinicians and patients choose the best course of treatment. But current methods fall short of the precision needed.

6 Jul 2016

Researchers discover human factor that drives maturation of helper T cells

A powerful arm of the immune system is production of antibodies that circulate through the blood and neutralize invading pathogens. Although B cells actually manufacture antibody proteins, the process is aided by neighboring T cells, which shower B cells with cytokines to make them churn out high-quality antibody proteins--and remember how to do so.

4 Jul 2016

Advances in inhaled drug delivery: an interview with Dr Robert Clarke

Delivering drugs to the lungs via inhalation has a number of potential advantages over traditional routes of administration like pills or injections. For treating pulmonary diseases, the obvious logic we are applying is topical delivery to the airways via inhalation.

1 Jul 2016

Researchers find new way for treating GBS infection in neonates

Researchers have discovered how the bacteria Group B streptococcus (GBS) avoids detection by the immune system during pregnancy.

28 Jun 2016

Jefferson researchers discover alternate pathway that helps heart keep pumping

About 5.7 million Americans have heart failure, half of whom will die from the disease within 5 years, according to the Centers for Disease Control and Prevention.

28 Jun 2016

Researchers investigate why N14Y, N14K mutations have distinct effects in KID syndrome patients

A team of New York-based researchers has compared the effects of two disease-causing mutations, potentially explaining why patients with the rare genetic disorder keratitis-ichthyosis-deafness (KID) syndrome can experience different sets of symptoms.

28 Jun 2016

ISU researchers design nanomachine capable of detecting mock version of Ebola virus

Imagine you want to build an intricate work of architecture, like a castle. Now imagine that, once all its individual components are brought together, the castle builds itself automatically. Finally, imagine this castle is so small that it's measured on the same scale as DNA, viruses and small molecules.

28 Jun 2016

TSRI scientists develop novel technique for finding drug candidates

Scientists at The Scripps Research Institute have developed a powerful new method for finding drug candidates that bind to specific proteins.

16 Jun 2016

EPFL researchers reprogram TAMs to prevent tumor metastasis

One of the major obstacles with treating cancer is that tumors can conscript the body's immune cells and make them work for them. Researchers at EPFL have now found a way to reclaim the corrupted immune cells, turn them into signals for the immune system to attack the tumor, and even prevent metastasis.

14 Jun 2016

Tiny molecular scaffolding could be key to fight against antibiotic resistance

Tiny molecular scaffolding that joins molecules together could be the key to our battle against antibiotic resistance. Research published in Bioorganic & Medicinal Chemistry Letters shows that carbon nanodot scaffolding assembled with small molecules called polyamines can kill some dangerous drug-resistant bacteria, including Acinetobacter baumanii and Klebsiella pneumonia.

14 Jun 2016

PET imaging can help identify autoimmune inflammation in MS

The triggers of autoimmune inflammation in multiple sclerosis (MS) have eluded scientists for many years, but molecular imaging is bringing researchers closer to identifying them, while providing a means of evaluating next-generation therapies for MS, say researchers introducing a study at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging.

14 Jun 2016

Small Molecules News and Research

TSRI study reveals new approach to intervene in deadly disease

Scientists create new cell-membrane-like material with potential for water purification and drug delivery

Study shows how dietary restriction impacts autophagy in intestine to increase lifespan

Scientists reveal how manipulating novel target in the brain could lead to new therapies for depression

Researchers identify potential biomarkers predictive of TKIs response in metastatic renal cancer

Experts discuss potential of DNA origami

Whole-genome omics data can improve accuracy of breast cancer survival predictions

Researchers discover human factor that drives maturation of helper T cells

Advances in inhaled drug delivery: an interview with Dr Robert Clarke

Researchers find new way for treating GBS infection in neonates

Jefferson researchers discover alternate pathway that helps heart keep pumping

Researchers investigate why N14Y, N14K mutations have distinct effects in KID syndrome patients

ISU researchers design nanomachine capable of detecting mock version of Ebola virus

TSRI scientists develop novel technique for finding drug candidates

EPFL researchers reprogram TAMs to prevent tumor metastasis

Tiny molecular scaffolding could be key to fight against antibiotic resistance

PET imaging can help identify autoimmune inflammation in MS

Scientists resuscitate efforts to crack KRas protein structures

Common angina drug can stimulate patient's own white blood cells to combat cryptococcosis

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