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Study reveals pathological mechanism and treatment strategy of pre-engraftment syndrome

The research team led by Prof. WEI Haiming and Prof. TIAN Zhigang from Division of Life Sciences and Medicine, University of Science and Technology of China of the Chinese Academy of Sciences, collaborating with the research group led by Prof. SUN Zimin from the First Affiliated Hospital of USTC revealed the pathological mechanism of severe pre-engraftment syndrome (PES) after umbilical cord blood transplantation, not only providing a treatment strategy for patients with PES, but significantly guiding for further improvement in the curative effect of unrelated cord blood transplantation (UCBT).

19 Jul 2021

Oral prodrug delivers carbon monoxide to protect against acute kidney injury

An oral prodrug developed by a team of scientists led by Binghe Wang, Regents' Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science.

19 Jul 2021

How do immunocompromised patients respond to COVID-19 vaccines?

The COVID-19 vaccines produce a boost in antibody activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, new research suggests vaccine responses aren’t all created equal. Their findings showed that immunocompromised patients, such as transplant recipients, with no prior exposure to SARS-CoV-2 produce little to no neutralizing antibodies.

18 Jul 2021

New concise recommendations for managing osteoporosis in patients with chronic kidney disease

Patients with advanced chronic kidney disease (CKD) typically suffer from impaired bone quality and quantity, with a non-vertebral fracture risk which is 4-to 6-fold higher than the fracture risk of matched controls. However, despite their high risk of fragility fractures, the vast majority of patients with chronic CKD stages 4 to 5D, are not receiving osteoporosis therapy.

15 Jul 2021

New study focuses on personalized therapies for people with severe asthma

A new phase 2 clinical trial of multiple therapies for severe asthma is underway in Northeast Ohio, with a focus on personalized therapies based on genetics, family history, lifestyle and environmental factors.

13 Jul 2021

Real-world evidence SARS-CoV-2 mRNA vaccines work and help prevent worst outcomes

Researchers in the United States have conducted a study demonstrating the real-world effectiveness of the Pfizer-BioNTech BNT162b2 and Moderna mRNA-1273 vaccines at preventing hospitalizations due to coronavirus disease 2019 (COVID-19).

12 Jul 2021

Researchers receive NIH grant to explore how imaging can help predict atrial fibrillation recurrence

A team led by researchers from Cleveland Clinic and Case Western Reserve University have received a $2.95 million grant over four years from the National Institutes of Health to explore how imaging can be used to predict the risk of atrial fibrillation recurrence.

12 Jul 2021

Researchers address ethical decisions related to split liver transplantation

Split liver transplantation (SLT) provides an opportunity to divide a donor liver and offer transplants to two small patients, one or both of whom could be a child. SLT, which is underused in the United States, could be used more widely to decrease the number of deaths of people on transplant waiting lists.

9 Jul 2021

Early B cell signatures predict antibody responses to mRNA-based COVID-19 vaccine

Researchers in the United States have identified both antigen-specific and antigen non-specific predictive signatures of antibody responses to Moderna’s two-dose coronavirus disease 2019 (COVID-19) vaccine that protects against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

8 Jul 2021

Scientists discover drug candidates for treating liver fibrosis among pesticides

Skoltech biologists and their colleagues from Koltzov Institute of Developmental Biology, Russia, and the Chemistry Department of Taras Shevchenko University in Ukraine have discovered fairly unlikely drug candidates for treating liver fibrosis and other pathologies -- among pest control chemicals.

8 Jul 2021

Experts offer guidance on diagnosis and treatment of myocarditis in children

Myocarditis in children is a rare yet challenging condition to treat. Diagnosis and treatment includes multiple options, and many cases of myocarditis resolve on their own, according to a new scientific statement from the American Heart Association, "Diagnosis and Management of Myocarditis in Children," published today in Circulation, the Association's flagship journal.

7 Jul 2021

Fecal transplant and fiber supplementation can benefit patients with obesity-related metabolic syndrome

A transplant of healthy gut microbes followed by fiber supplements benefits patients with severe obesity and metabolic syndrome, according to University of Alberta clinical trial findings published today in Nature Medicine.

6 Jul 2021

Angiotensin II type 1 receptor-targeting autoantibodies may increase COVID-19 severity

A team of US-based scientists recently demonstrated that pro-thrombotic autoantibodies that target angiotensin II type 1 receptor (AT1R) may be associated with endothelial complications observed in coronavirus disease 2019 (COVID-19), a novel disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Jul 2021

Gene-edited cellular therapeutics can successfully treat cardiovascular and pulmonary diseases

Scientists at UC San Francisco have shown that gene-edited cellular therapeutics can be used to successfully treat cardiovascular and pulmonary diseases, potentially paving the way for developing less expensive cellular therapies to treat diseases for which there are currently few viable options.

6 Jul 2021

COVID-19 vaccination induces highly variable immunity among the immunocompromised

Researchers in the United States have conducted a study showing that the humoral (antibody) immunity induced by vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – varies significantly among immunocompromised individuals.

4 Jul 2021

New clinical and prognostic characteristics discovered in solid organ recipients with COVID-19

Researchers from 12 Spanish hospitals took part with the aim of uncovering clinical and prognostic characteristics in solid organ recipients with COVID-19. The conclusions underscore the need for strict preventive measures in the initial period after transplantation.

2 Jul 2021

Transplant News and Research

Study reveals pathological mechanism and treatment strategy of pre-engraftment syndrome

Oral prodrug delivers carbon monoxide to protect against acute kidney injury

How do immunocompromised patients respond to COVID-19 vaccines?

New concise recommendations for managing osteoporosis in patients with chronic kidney disease

New study focuses on personalized therapies for people with severe asthma

Real-world evidence SARS-CoV-2 mRNA vaccines work and help prevent worst outcomes

Researchers receive NIH grant to explore how imaging can help predict atrial fibrillation recurrence

Researchers address ethical decisions related to split liver transplantation

Early B cell signatures predict antibody responses to mRNA-based COVID-19 vaccine

Scientists discover drug candidates for treating liver fibrosis among pesticides

Experts offer guidance on diagnosis and treatment of myocarditis in children

Fecal transplant and fiber supplementation can benefit patients with obesity-related metabolic syndrome

Angiotensin II type 1 receptor-targeting autoantibodies may increase COVID-19 severity

Gene-edited cellular therapeutics can successfully treat cardiovascular and pulmonary diseases

COVID-19 vaccination induces highly variable immunity among the immunocompromised

New clinical and prognostic characteristics discovered in solid organ recipients with COVID-19

UB scientists publish a detailed guide for producing mature human cells in a mouse embryo

Stool transplant may be worth exploring as treatment option for COVID-19

Researchers seek to quantify immunogenicity of COVID vaccines in immunocompromised patients

The impact of COVID-19 on dialysis patients

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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