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Surgery improves survival in late-stage NSCLC patients

Patients with late-stage, non-small cell lung cancer (NSCLC) who have surgery have better survival rates than those who don't, but fewer of these patients are undergoing surgery, UC Davis researchers have found.

9 Jun 2016

New endoscopic scanner may help in early detection of cancer

UPM researchers are involved in a European network to develop an endoscopic scanner for early detection of certain types of cancers that have a high mortality rate today.

9 Jun 2016

Simple breath test shows promise in identifying lung cancer recurrence after surgery

A single breath may be all it takes to identify the return of lung cancer after surgery, according to a study posted online today by The Annals of Thoracic Surgery.

9 Jun 2016

PD surgery improves quality of life in patients with malignant pleural mesothelioma

Although surgery can prolong the lives of patients with an aggressive type of cancer called malignant pleural mesothelioma, many patients avoid the operation for fear it will degrade their quality of life.

9 Jun 2016

Novel methods may help assess multipotent or unipotent fate of mammary gland, prostate stem cells

Stem cells ensure the development of tissues, their daily maintenance and their repair following injuries. One of the key questions in the field of stem cell biology is to define the different cell lineages in which stem cells can differentiate into.

9 Jun 2016

Whole-exome sequencing can help characterize genetic alterations for commonly used bladder cancer cell lines

Much of basic cancer research is based on studies with cultured cancer cells. However, the usefulness of these studies greatly depends on how accurately these cancer cells grown in a dish represent human tumors.

9 Jun 2016

Drug candidate delivered by plant-virus-based carrier shows promise for triple-negative breast cancer

In a pair of firsts, researchers at Case Western Reserve University and Massachusetts Institute of Technology have shown that the drug candidate phenanthriplatin can be more effective than an approved drug in vivo, and that a plant-virus-based carrier successfully delivers a drug in vivo.

9 Jun 2016

NMR-based metabolomics: an interview with Prof. Claudio Luchinat

Professor Claudio Luchinat, University of Florence and co-founder of the Magnetic Resonance Center (CERM), speaks to News-Medical about his research in NMR-based metabolomics.

From Bruker BioSpin - NMR, EPR and Imaging 9 Jun 2016

Transplantation of hpNSCs into non-human primates modeled with PD promotes behavioral recovery

A multi-center team of researchers in the U.S. testing the potential of cell therapy for treating Parkinson's disease (PD) has found that grafting human parthenogenetic stem cell-derived neural stem cells (hpNSCs) into non-human primates modeled with PD promoted behavioral recovery, increased dopamine concentrations in the brain, and induced the expression of beneficial genes and pathways when compared to control animals not transplanted with stem cells.

9 Jun 2016

New technology can detect KRAS gene mutations, facilitate targeted therapies for lung and colorectal cancers

A new technology suitable for practical clinical testing can detect KRAS gene mutations in lung and colorectal cancers and could thereby facilitate targeted therapies, according to a new report in The Journal of Molecular Diagnostics.

8 Jun 2016

Researchers identify lymphatic endothelial lineage that shows potential for new anti-cancer treatment

Identifying the cell of origin is crucial to understanding how a tumor develops and metastasizes and for developing targeted therapies.

8 Jun 2016

New drug-capture device can soak up chemotherapy drugs to limit toxicity

Doctors have a powerful arsenal of cancer-fighting chemotherapy drugs to choose from, though a key challenge is to better target these drugs to kill tumors while limiting their potentially harmful side effects.

8 Jun 2016

New mathematical model helps examine metabolism of breast epithelium

Researchers have built a model to investigate the metastasis of cancer by examining the metabolism of breast epithelial cells and look at the role of signaling. This research, published in PLOS Computational Biology, may contribute to the development of cell specific anti-cancer interventions.

8 Jun 2016

Two autologous stem-cell transplants improve survival of children with high-risk neuroblastoma

Children with high-risk neuroblastoma whose treatment included two autologous stem-cell transplants were more likely to be free of cancer three years later than patients who underwent a single transplant, a Phase 3 clinical trial has found.

7 Jun 2016

Personalized therapy shows improved response in cancer patients

In a meta-analysis of hundreds of clinical trials involving thousands of patients, researchers at University of California San Diego School of Medicine report that therapeutic approaches using precision medicine, which emphasizes the use of individual genetics to refine cancer treatment, showed improved response and longer periods of disease remission, even in phase I trials.

7 Jun 2016

Existing immunotherapy drug pembrolizumab shows promise for specific sarcoma subtypes

An existing cancer immunotherapy drug reduces tumor size in some types of rare connective tissue cancers, called sarcomas, report researchers at the University of Pittsburgh Cancer Institute.

7 Jun 2016

New study identifies PDGFRα as key molecule for HCMV viral entry

A publication in the scientific journal Nature Microbiology identifies PDGFRα as the receptor for the trimeric gHgLgO complex of Human cytomegalovirus (HCMV).

7 Jun 2016

Pembrolizumab drug shows significant clinical responses in metastatic head and neck cancer patients

Treating head and neck cancer patients with recurrent or metastatic disease with the PD-1 inhibitor pembrolizumab resulted in significant clinical responses in a fifth of the patients from a phase II clinical trial, researchers at the Abramson Cancer Center of the University of Pennsylvania and other institutions reported at the 2016 American Society of Clinical Oncology annual meeting.

7 Jun 2016

Innovative mouse model could provide new strategy to arrest growth of pancreatic cancer

Pancreatic ductal adenocarcinoma, the most common of pancreatic cancers, is extraordinarily lethal, with a 5-year survival rate of just 6 percent. Chemotherapy treatments are poorly effective, in part due to a high degree of drug-resistance to currently used regimens.

7 Jun 2016

Clinical study shows improved outcomes for NET patients treated with Lutathera over Octreotide LAR

NETTER-1 study, showing clinically meaningful and significant results for Lutathera (77Lu-DOTA0-Tyr3-Octreotate) in patients with metastatic midgut neuroendocrine tumors (NETs). The data will be presented Monday, June 6, during the American Society of Clinical Oncology Annual Meeting in Chicago.

6 Jun 2016

Tumor News and Research

Surgery improves survival in late-stage NSCLC patients

New endoscopic scanner may help in early detection of cancer

Simple breath test shows promise in identifying lung cancer recurrence after surgery

PD surgery improves quality of life in patients with malignant pleural mesothelioma

Novel methods may help assess multipotent or unipotent fate of mammary gland, prostate stem cells

Whole-exome sequencing can help characterize genetic alterations for commonly used bladder cancer cell lines

Drug candidate delivered by plant-virus-based carrier shows promise for triple-negative breast cancer

NMR-based metabolomics: an interview with Prof. Claudio Luchinat

Transplantation of hpNSCs into non-human primates modeled with PD promotes behavioral recovery

New technology can detect KRAS gene mutations, facilitate targeted therapies for lung and colorectal cancers

Researchers identify lymphatic endothelial lineage that shows potential for new anti-cancer treatment

New drug-capture device can soak up chemotherapy drugs to limit toxicity

New mathematical model helps examine metabolism of breast epithelium

Two autologous stem-cell transplants improve survival of children with high-risk neuroblastoma

Personalized therapy shows improved response in cancer patients

Existing immunotherapy drug pembrolizumab shows promise for specific sarcoma subtypes

New study identifies PDGFRα as key molecule for HCMV viral entry

Pembrolizumab drug shows significant clinical responses in metastatic head and neck cancer patients

Innovative mouse model could provide new strategy to arrest growth of pancreatic cancer

Clinical study shows improved outcomes for NET patients treated with Lutathera over Octreotide LAR

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Exploring the G:Box and for high-quality imaging

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