Signaling Pathway News and Research

RSS

STING signaling pathway induces apoptosis in T cells

EPFL scientists show that the STING signaling pathway, which helps coordinate the innate immune system, causes cell death in T cells of the adaptive immune system. This “killing” effect includes cancerous T cells, and has implications for treating T cell-derived cancers.

5 Sep 2017

New study offers insights on mechanisms behind development of kidney damage due to obesity

A new study provides insights on the mechanisms behind the development of kidney damage due to obesity. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology, point to a potential target for protecting the kidney health of individuals with obesity.

1 Sep 2017

Fat may influence cancer development in diverse ways

Adipose tissue, or fat, may influence the development of cancer in diverse ways, depending on the type of fat and the location in the body.

1 Sep 2017

New biomedical tool using nanoparticles could improve therapies for many diseases

A new biomedical tool using nanoparticles that deliver transient gene changes to targeted cells could make therapies for a variety of diseases -; including cancer, diabetes and HIV -; faster and cheaper to develop, and more customizable.

30 Aug 2017

Research may lead to first-ever pharmacological treatment for rare genetic bone disease

Scientists at Children's Hospital of Philadelphia report that a drug candidate that blocks abnormal protein signals may lead to the first pharmacologic treatment for hereditary multiple exostoses (HME), a rare pediatric genetic disease.

29 Aug 2017

IBS scientists uncover key regulator of normal as well as pathological angiogenesis

New blood vessels branch out of preexisting ones is via a process called angiogenesis. Although this is essential for survival, development and wound healing, on the flip side, it also feeds and progresses malignant tumors, as well as other diseases.

29 Aug 2017

Study tests therapeutic effect of conventional and new cancer drug combinations

Cancer is one of the major causes of death worldwide affecting 8.2 million of people per year, and in the US, the number of new cases will achieve 1.6 million in 2017. The global impact of this disease costs a trillion of dollars, which makes critical the development of new drugs and treatment against it.

28 Aug 2017

Manipulation of single gene defines new pathway to mood disorders

Removing a single gene from the brains of mice and zebrafish causes these animals to become more anxious than normal.

24 Aug 2017

Study may lead to new therapy options for treatment resistant, relapsed endometrial cancer

A team of Cleveland Clinic researchers have discovered a key pathway that leads to recurrence and treatment resistance in endometrial cancer, providing the potential for much needed new therapies for women with limited options.

24 Aug 2017

Study shows role of exhausted regulatory T cells in allergic reactions

Researchers have evidence that the specialized T cells responsible for maintaining a balanced immune response are vulnerable to exhaustion that disrupts normal functioning and may even contribute to allergic reactions.

23 Aug 2017

Research identifies new gene fusions and mutations linked to GIST tumors

Researchers at UC San Diego Moores Cancer Center, with colleagues from Memorial Sloan Kettering Cancer Center and Fox Chase Cancer Center, have determined that a specific region of the small bowel, called the duodenal-jejunal flexure or DJF, shows a high frequency of gastrointestinal stromal tumors (GISTs) with mutations of the NF1 gene

18 Aug 2017

Researchers hint at experimental molecular treatment for heart failure

Researchers report encouraging preclinical results as they pursue elusive therapeutic strategies to repair scarred and poorly functioning heart tissues after cardiac injury – describing an experimental molecular treatment for heart failure.

14 Aug 2017

Study: Liver inflammation increases cholesterol levels in people with diabetes

Inflammatory processes in the liver lead to elevated cholesterol levels in people with diabetes, thus promoting subsequent vascular diseases. This is the result of a study by scientists of Helmholtz Zentrum München, Technische Universität München and the Collaborative Research Center SFB 1118 at Heidelberg University Hospital.

14 Aug 2017

Signaling Pathway News and Research

STING signaling pathway induces apoptosis in T cells

New study offers insights on mechanisms behind development of kidney damage due to obesity

Fat may influence cancer development in diverse ways

New biomedical tool using nanoparticles could improve therapies for many diseases

Research may lead to first-ever pharmacological treatment for rare genetic bone disease

IBS scientists uncover key regulator of normal as well as pathological angiogenesis

Study tests therapeutic effect of conventional and new cancer drug combinations

Manipulation of single gene defines new pathway to mood disorders

Study may lead to new therapy options for treatment resistant, relapsed endometrial cancer

Study shows role of exhausted regulatory T cells in allergic reactions

Research identifies new gene fusions and mutations linked to GIST tumors

Researchers hint at experimental molecular treatment for heart failure

Study: Liver inflammation increases cholesterol levels in people with diabetes

Biomedical scientist receives $1.83 million NIH grant for inflammatory bowel disease research

New research uncovers how dietary fiber helps intestinal cells maintain gut health

Tiny lab-grown structures that resemble amniotic sac may help in infertility research

Sheffield scientists discover that simple arthritis drug could help treat blood cancer sufferers

New findings could help better understand aging process and extend lifespan

Synthetic molecule can disrupt hunger-signaling pathway, research suggests

Gene editing technology shines light on rare dyskeratosis congenita

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

Latest News