Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Proteomics analysis from aggressive human cancers can help identify potential therapeutic targets

Researchers at Baylor College of Medicine show that analysis of the proteomics, or all the protein data, from aggressive human cancers is a useful approach to identify potential novel therapeutic targets.

4 Mar 2021

How Ecodyst’s Modern Rotovap Revolutionizes Rotovap Technology

In this interview, NewsMed talks to George Adjabeng about the revolutionary new rotovap, Ecodyst Hydrogen, and how it supersedes traditional rotovap models,

From Ecodyst 4 Mar 2021

Direct electron introduces Apollo

Direct Electron, a leading producer of next-generation direct detection cameras for transmission electron microscopes (TEM), today announces Apollo, a revolutionary new event-based direct detection camera for electron cryo-microscopy (cryo-EM). Based on a next generation sensor and camera architecture delivering electron counting in hardware, Apollo is the highest throughput direct detector for cryo-EM.

From Direct Electron, LP 4 Mar 2021

Dotmatics announces licensing agreement for informatics software with Compugen

Dotmatics Ltd, a scientific informatics software and services company that is driving the automation of laboratory data workflows for scientific discovery and innovation research, today announced it has entered a licensing agreement with Compugen, a clinical-stage drug discovery and development company focused on immuno-oncology.

From Dotmatics 3 Mar 2021

Comet supercomputer reveals the mechanical process of cancer growth

According to the World Health Organization, one in six worldwide deaths have been attributed to cancer; however, these fatalities were not due to initial malignant tumors-;the deaths were caused by the spread of cancer cells to surrounding tissues and subsequent tumor growth.

3 Mar 2021

CN Bio awarded Innovate UK grant to develop single and multi-organ models for COVID-19 research

CN Bio today announced it has received a grant from Innovate UK to develop human-relevant MPS to advance investigations into SARS-CoV-2 infection.

From CN-Bio 2 Mar 2021

Biological activity-based modeling offers a new approach for drug discovery

Assessing a drug compound by its activity, not simply its structure, is a new approach that could speed the search for COVID-19 therapies and reveal more potential therapies for other diseases.

2 Mar 2021

Efficacy of polymeric nano-micelles depends on expression level of c-Myc

The Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki in Japan, Abbreviation: iCONM) reported in ACS Nano (Impact Factor: 14.588 in 2019) together with the group of Prof. Yu Matsumoto of Otorhinolaryngology and Head and Neck Surgery (Prof. Tatsuya Yamasoba) and the group of Prof. Horacio Cabral of the Department of Bioengineering (Prof. Ryo Miyake) in the University of Tokyo that the efficacy of polymeric nano-micelles with different drug activation profile depends on the expression level of c-Myc, one of the major proto-oncogene, has been developed.

27 Feb 2021

Repurposed drugs show antiviral SARS-CoV-2 E channel blocking activity, finds study

A new study by researchers at The Hebrew University of Jerusalem in Israel reports the discovery of a promising group of E channel inhibitors with significant antiviral activity. This could be developed into new treatment agents for this often-deadly virus.

26 Feb 2021

New approach harnesses disease-causing proteins to combat cancer

Over many decades now, traditional drug discovery methods have steadily improved at keeping diseases at bay and cancer in remission. And for the most part, it's worked well.

26 Feb 2021

Insilico Medicine discovers novel preclinical candidate to address idiopathic pulmonary fibrosis

Insilico Medicine has demonstrated a breakthrough in Artificial Intelligence ("AI") and drug discovery -- linking together generative chemistry and biology for the first time -- to discover a novel preclinical candidate addressing idiopathic pulmonary fibrosis ("IPF") and be validated with multiple human cell and animal model experiments.

25 Feb 2021

Microchip can help scientists study the regenerative potential of mice heart cells

Baby mice might be small, but they're tough, too. For their first seven days of life, they have the special ability to regenerate damaged heart tissue.

25 Feb 2021

New book focuses on rational drug design and discovery

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery.

25 Feb 2021

Complement system appears to be specifically implicated in severe COVID-19

Researchers in the United States have conducted a study showing that activation of the complement system is specifically implicated in the pathogenesis of severe coronavirus disease 2019 (COVID-19), rather than being a broader indicator of critical illness.

24 Feb 2021

mRNA Therapeutics – Analytical and Bioanalytical Characterization

NewsMed interviews Anette Bak from AstraZeneca about her research on developments in mRNA therapeutics that she will present at Pittcon 2021.

From Pittcon 23 Feb 2021

Researchers create high throughput arrays of miniaturized 3D tumor models

By engineering common filter papers, similar to coffee filters, a team of NYU Abu Dhabi researchers have created high throughput arrays of miniaturized 3D tumor models to replicate key aspects of tumor physiology, which are absent in traditional drug testing platforms.

22 Feb 2021

Insights into molecular tools shared across coronaviruses could provide potential target for COVID-19

Coronaviruses exploit our cells so they can make copies of themselves inside us. After they enter our cells, they use our cell machinery to make unique tools of their own that help them generate these copies.

22 Feb 2021

Researchers track how Osmium reacts in a single cancer cell

Osmium is a rare precious metal that could be used to treat cancer with fewer side effects when compared to Platinum, currently used in nearly half of chemotherapies.

17 Feb 2021

ERS Genomics and ZeClinics sign CRISPR/Cas9 license agreement

ERS Genomics Limited, which was formed to provide broad access to the foundational CRISPR/Cas9 intellectual property co-owned by Dr. Emmanuelle Charpentier, and ZeClinics, a contract research organization using zebrafish to carry out services focused on analyzing the safety, efficacy and biomedical relevance of new compounds, today announced a non-exclusive license agreement granting ZeClinics access to ERS Genomics’ CRISPR/Cas9 patent portfolio.

From ZeClinics SL 16 Feb 2021

New zebrafish model could help advance glioblastoma multiforme research

Scientists at the Fralin Biomedical Research Institute at VTC have identified a new zebrafish model that could help advance glioblastoma multiforme research. Glioblastoma is an aggressive form of primary brain tumor - fewer than one in 20 patients survive five years after diagnosis.

13 Feb 2021