Small Molecules News and Research

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High–performance, cost-effective NMR solutions for the pharmaceutical and chemical industries

At the 57th Experimental Nuclear Magnetic Resonance Conference (www.enc-conference.org), Bruker is showcasing several innovative drug discovery, drug development and process control solutions for small molecule NMR characterization in the chemical and pharmaceutical industries.

From Bruker BioSpin - NMR, EPR and Imaging 11 Apr 2016

AstraZeneca, MedImmune to present new clinical trial and scientific data on lung cancer treatments at ELCC 2016

AstraZeneca and its global biologics research and development arm, MedImmune, will report new clinical trial and scientific data from their industry-leading lung cancer franchise of marketed and pipeline medicines at the European Lung Cancer Conference in Geneva, Switzerland, 13 -16 April 2016.

11 Apr 2016

Blocking blood supply of small cell lung cancer tumors may help delay cancer relapse

A study by researchers at Marshall University Joan C. Edwards School of Medicine has found that blocking the blood supply of small cell lung cancer tumors may help reduce their growth and delay the regrowth process after treatment. Small cell lung cancer is considered the most lethal of all lung cancers.

5 Apr 2016

UTA chemists design efficient water-based system for synthesis of organic compounds

Chemists at The University of Texas at Arlington have devised a safer, more environmentally friendly, less expensive and more efficient water-based system for the synthesis of organic compounds typically used in pharmaceuticals, agrochemicals, cosmetics, plastics, textiles and household chemicals.

29 Mar 2016

New form of molecular tags enhance MRI signals by 10,000-fold

Duke University researchers have taken a major step towards realizing a new form of MRI that could record biochemical reactions in the body as they happen.

26 Mar 2016

Inactivation of protein-coding gene promotes liver tissue regeneration in mammals

Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) report that inactivating a certain protein-coding gene promotes liver tissue regeneration in mammals.

26 Mar 2016

MALDI tissue imaging spots early renal lipid changes in acute kidney injury

University of Alabama at Birmingham researchers have made a microscopic snapshot of the early renal lipid changes in acute kidney injury, using the laser-scanning method called MALDI tissue imaging to localize the changes.

24 Mar 2016

FEI, NovAliX to jointly provide cryo-EM-based structural analysis services for pharmaceutical and biotech industry

FEI and NovAliX, a contract research organization (CRO), announced today a strategic partnership to enable NovAliX to provide commercial cryo-electron microscopy (EM)-based structural analysis services to its customers in the pharmaceutical and biotech industry.

From Thermo Fisher Scientific – Electron Microscopy Solutions 23 Mar 2016

Addition of just two DNA bases to LdAQP1 gene helps Black Fever parasite to overcome antimonial drugs

Wellcome Trust Sanger Institute scientists show how the parasite responsible for the neglected tropical disease Black Fever (visceral leishmaniasis) can become resistant to drug treatment. Studying the whole genomes of more than 200 samples of Leishmania donovani revealed that the addition of just two bases of DNA to a gene known as LdAQP1 stops the parasite from absorbing antimonial drugs.

23 Mar 2016

Johns Hopkins scientists develop antibody to curb lung tumor cell growth, breast cancer metastasis

Johns Hopkins scientists report they have developed an antibody against a specific cellular gateway that suppresses lung tumor cell growth and breast cancer metastasis in transplanted tumor experiments in mice, according to a new study published in the February issue of Nature Communications.

17 Mar 2016

New method to harvest stem cells reduces side effects for donors

Australian scientists have developed a new method for harvesting stem cells, which is less invasive and reduces side effects for donors.

16 Mar 2016

Ibrutinib and idelalisib drugs for chronic lymphatic leukaemia can prolong survival time of high-risk patients

Studies conducted at the Comprehensive Cancer Center at MedUni Vienna and Vienna General Hospital show that the drugs ibrutinib and idelalisib used in the targeted treatment of chronic lymphatic leukaemia can significantly prolong the survival time of high-risk patients.

15 Mar 2016

Scientists discover novel drug candidate to treat breast cancer, lung cancer and melanoma

Using a new approach, scientists at The Scripps Research Institute and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma.

10 Mar 2016

Bioengineers introduce CORDA algorithm to find new therapeutic targets for cancer

Rice University bioengineers have introduced a fast computational method to model tissue-specific metabolic pathways. Their algorithm may help researchers find new therapeutic targets for cancer and other diseases.

10 Mar 2016

Pittcon 2016: Bruker showcases new products and analytical solutions

This week at Pittcon 2016, Bruker is showcasing new products and analytical solutions for core Applied & Pharma markets, for our Nanoanalysis, Microscopy & Advanced Materials Research markets, as well as new after-market services and life-cycle support solutions for our customers.

From Bruker BioSpin - NMR, EPR and Imaging 8 Mar 2016

New screening technique to test drug compounds used in Ewing sarcoma treatment

In Ewing sarcoma, cancer cells' DNA is unwound abnormally from a condensed, compact state. Once sections of genetic code are open, key genes are turned on to help direct aggressive and cancerous cell growth.

1 Mar 2016

Cryo-electron microscopy helps analyze infection mechanisms of coronaviruses in detail

High-resolution cryo-electron microscopy and supercomputing have now made it possible to analyze in detail the infection mechanisms of coronaviruses. These viruses are notorious for attacking the respiratory tract of humans and animals.

27 Feb 2016

Novel therapeutic approach to target monomeric Tau protein

Dementia and other tauopathies, most notably Alzheimer's disease, embody a class of neurodegenerative diseases associated with the aggregation of the Tau protein in the human brain. These diseases represent one of the leading causes of death and disability in the elderly population in the western world, with no current effective therapy.

27 Feb 2016

New molecular delivery system could help ensure delivery of chemotherapy drugs into tumours

Chemotherapy isn't supposed to make your hair fall out -- it's supposed to kill cancer cells. A new molecular delivery system created at U of T Engineering could help ensure that chemotherapy drugs get to their target while minimizing collateral damage.

22 Feb 2016

Researchers reveal how brain-specific microRNA plays key role in causing abnormal brain development

Autism Spectrum Disorders (ASDs) are a group of highly inheritable behavioural disorders that pose major personal and public health concerns. Patients with ASDs have mild to severe communication difficulties, repetitive behaviour and social challenges. Such disorders significantly challenge an individual's ability to conduct daily activities and function normally in society. Currently there are very few medication options that effectively treat ASDs.

17 Feb 2016