Small Molecules News and Research

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Study reveals another clue to workings of trachoma

Another clue to the workings of trachoma - the world's leading infectious cause of blindness - has been revealed in a new study published in BMC Infectious Diseases. Researchers identified markers of genetic regulation present in the early stages of infection that could predispose children to developing the condition in its long-term, severe form.

17 Feb 2016

Research shows how developing neurons use copper for their various needs

Researchers at Johns Hopkins have used a precision sensor in a chicken embryo to find dramatic differences in the use of copper between developing and fully mature neurons.

17 Feb 2016

Anti-cancer drug delays onset of Alzheimer's disease

Researchers have identified a drug that targets the first step in the toxic chain reaction leading to the death of brain cells, suggesting that treatments could be developed to protect against Alzheimer's disease, in a similar way to how statins are able to reduce the risk of developing heart disease.

15 Feb 2016

Pioneering technique shows promise for new medical diagnostics, targeted drug delivery

Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules--the enzymes.

12 Feb 2016

Nutrients in food may influence our genes

Almost all of our genes may be influenced by the food we eat, suggests new research published today in the journal Nature Microbiology. The study, carried out in yeast - which can be used to model some of the body's fundamental processes - shows that while the activity of our genes influences our metabolism, the opposite is also true and the nutrients available to cells influence our genes.

12 Feb 2016

Unlocking intrinsically disordered proteins: an interview with Peter Wright

I'm a professor in the Department of Integrative Structural and Computational Biology at The Scripps Research Institute. I have been performing NMR research on proteins for nearly 40 years.

From Bruker BioSpin - NMR, EPR and Imaging 11 Feb 2016

New technique allows better understanding of cellular stress reaction

Stress in the body's cells is both the cause and consequence of inflammatory diseases or cancer. The cells react to stress to protect themselves. Researchers at the University of Zurich have now developed a new technique that allows studying a fundamental response to stress in much more detail than previously possible: the ADP-ribosylation of chromatin.

9 Feb 2016

Upsher-Smith, Saniona sign drug discovery and development agreement

Upsher-Smith Laboratories, Inc., through its wholly-owned subsidiary Proximagen Ltd., and Saniona, a leading biotech company in the field of ion channels, today announce that they have entered into a drug discovery and development collaboration.

20 Jan 2016

Automated OpenSPR-XT will accelerate discoveries in protein science

Nicoya Lifesciences, a leader in label-free molecular analysis, announced today its newest product, OpenSPR-XT - a fully automated molecular analysis instrument based on the highly successful OpenSPR instrument.

From Nicoya Lifesciences 20 Jan 2016

Antivirulence antibiotics could evade resistance longer than traditional antibiotics

We've all seen the headlines. "Man found to be shedding virulent strain of polio"; "Virulent flu strain in Europe hits the economy"; "Most virulent strain of E. coli ever seen contains DNA sequences from plague bacteria."

19 Jan 2016

Scientists identify unusual regulator of body weight, metabolic syndrome

Scientists at the Gladstone Institutes have discovered an unusual regulator of body weight and the metabolic syndrome: a molecular mechanism more commonly associated with brain cells. Lowering levels of P75 neurotrophin receptor (NTR)--a receptor involved in neuron growth and survival--protected mice fed a high-fat diet from developing obesity, diabetes, and fatty liver disease.

12 Jan 2016

Discoveries could lead to development of novel therapies to prevent C. diff infection

Researchers at Vanderbilt University Medical Center have obtained the crystal structure of a toxin from the bacterium Clostridium difficile ("C. diff") -- the leading cause of hospital-acquired diarrhea in the United States.

12 Jan 2016

Scientists discover protein interaction that describes aggressive subtype of medulloblastoma

Scientists at St. Jude Children's Research Hospital and the University of Würzburg in Germany have identified a protein interaction that is a hallmark of an aggressive subtype of medulloblastoma and that may provide a new treatment strategy.

12 Jan 2016

Research could lead to new treatment for Rett Syndrome, other forms of autism

Penn State scientists have discovered a novel drug target and have rescued functional deficits in human nerve cells derived from patients with Rett Syndrome, a severe form of autism-spectrum disorder.

11 Jan 2016

Jubilant Biosys, Sanofi partner to develop small molecule inhibitors in metabolic disorders therapeutic area

Jubilant Biosys Ltd, a Bengaluru-based subsidiary of Jubilant Life Sciences Ltd, and Sanofi Deutschland GmbH, Frankfurt, Germany, announced a strategic alliance to discover and develop small molecule inhibitors for multiple targets in the metabolic disorders therapeutic area.

7 Jan 2016

Microencapsulation method can help overcome challenges in pancreatic islet transplantation

A microencapsulation method, developed by OIST researchers, can help to overcome major challenges in pancreatic islet transplantation.

26 Dec 2015

New nanotechnology approach could transform gliomas from death sentence into treatable condition

An MRI contrast agent that can pass through the blood-brain barrier will allow doctors to detect deadly brain tumors called gliomas earlier, say Penn State College of Medicine researchers. This ability opens the door to make this fatal cancer treatable.

18 Dec 2015

Study paves way for development of novel cancer therapeutics

A team of scientists, comprising researchers from the Institute of Molecular and Cell Biology, a research institute under the Agency for Science, Technology and Research, Singapore, and the VIB Laboratory of Molecular Cancer Biology, has revealed the mechanism by which tumor cells elevate levels of MDM4, a protein that is highly expressed in cancer cells but not in normal adult tissues.

16 Dec 2015

Heptares announces strategic drug discovery collaboration with Pfizer

Heptares Therapeutics, the clinical-stage GPCR structure-guided drug discovery and development company and wholly-owned subsidiary of Sosei Group Corporation, announces that it has entered into a strategic drug discovery collaboration with Pfizer Inc. to research and develop potential new medicines directed at up to 10 G protein-coupled receptor (GPCR) targets across multiple therapeutic areas.

30 Nov 2015

Study points to new avenue for developing potential strategies to thwart HIV virus

Nearly 37 million people worldwide are living with HIV. When the virus destroys so many immune cells that the body can't fight off infection, AIDS will develop. The disease took the lives of more than a million people last year.

26 Nov 2015

Small Molecules News and Research

Study reveals another clue to workings of trachoma

Research shows how developing neurons use copper for their various needs

Anti-cancer drug delays onset of Alzheimer's disease

Pioneering technique shows promise for new medical diagnostics, targeted drug delivery

Nutrients in food may influence our genes

Unlocking intrinsically disordered proteins: an interview with Peter Wright

New technique allows better understanding of cellular stress reaction

Upsher-Smith, Saniona sign drug discovery and development agreement

Automated OpenSPR-XT will accelerate discoveries in protein science

Antivirulence antibiotics could evade resistance longer than traditional antibiotics

Scientists identify unusual regulator of body weight, metabolic syndrome

Discoveries could lead to development of novel therapies to prevent C. diff infection

Scientists discover protein interaction that describes aggressive subtype of medulloblastoma

Research could lead to new treatment for Rett Syndrome, other forms of autism

Jubilant Biosys, Sanofi partner to develop small molecule inhibitors in metabolic disorders therapeutic area

Microencapsulation method can help overcome challenges in pancreatic islet transplantation

New nanotechnology approach could transform gliomas from death sentence into treatable condition

Study paves way for development of novel cancer therapeutics

Heptares announces strategic drug discovery collaboration with Pfizer

Study points to new avenue for developing potential strategies to thwart HIV virus

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