Immune Response News and Research

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Scientists document an organ-specific innate immune system

In research published in the April 18 edition of the journal Immunity, scientists at the University of California, San Diego (UCSD) School of Medicine outline the unique mechanism by which the lung shapes its defensive strategies against microbial invasion.

18 Apr 2006

Doses of DNA-gene-coated gold particles protect against harmful protein implicated in Alzheimer's disease

Doses of DNA-gene-coated gold particles protect mice against a protein implicated in Alzheimer's disease, researchers at UT Southwestern Medical Center have found.

16 Apr 2006

IL-25 both promotes and limits inflammatory diseases

The same signal responsible for promoting the type of immune responses that cause asthma and allergy can also limit the type of inflammation associated with debilitating diseases like inflammatory bowel disease, arthritis and multiple sclerosis, according to researchers from the University of Pennsylvania School of Veterinary Medicine.

13 Apr 2006

Minimal nutritional requirements for growing and maintaining human embryonic stem cells

Researchers at Yale have established the minimal nutritional requirements for growing and maintaining human embryonic stem cells, a recipe that is critical for clinical application and for developmental studies, according to a report in the Proceedings of the National Academy of Sciences.

11 Apr 2006

Drug trial disaster will discourage future volunteers

According to the British government agency responsible for medical safety, the Medicines and Healthcare Products Regulatory Agency (MHRA), no evidence has been found to suggest there were any problems with the manufacturing of a drug which left six volunteers seriously ill.

6 Apr 2006

Researchers aim to develop instrument to help physicians estimate risk for developing lung cancer

Physicians have little to help them predict development of lung cancer in their patients - even a history of heavy smoking doesn't really help, since only a small fraction of lifetime smokers develops the cancer.

6 Apr 2006

Evidence of estrogen and progesterone hormone allergy discovered

Some women with menstrual cycle disorders like asthma and migraine headaches may be experiencing allergies to their own estrogen and progesterone hormones, Texas researchers have discovered.

4 Apr 2006

Nrf2 gene findings may offer therapeutic potential for sepsis treatment

Disruption of a single gene, Nrf2, plays a critical role in regulating the body's innate immune response to sepsis and septic shock, according to a study by a research team led by Shyam Biswal, PhD, at the Johns Hopkins Bloomberg School of Public Health.

4 Apr 2006

Novel approach to creating a vaccine to treat melanoma

A novel approach to creating a vaccine to treat melanoma has demonstrated promising effectiveness in a new laboratory study led by researchers at The Wistar Institute. About a third of melanoma patients might benefit from such a vaccine.

4 Apr 2006

Researchers reverse juvenile diabetes in animal model

Groundbreaking human clinical trial for type 1 diabetes to start this spring in Pittsburgh - Children's Hospital of Pittsburgh of UPMC researchers reverse juvenile diabetes in animal model; Phase 1 clinical trial approved by FDA.

4 Apr 2006

New mouse model technology in cancer vaccine tool-box

Cancer vaccines are being investigated in early-phase clinical trials around the world, with many of those trials recruiting patients with melanoma.

4 Apr 2006

Targeting of angiogenic endothelial cells at sites of inflammation by Dexamethasone Phosphate-containing RGD peptide liposomes inhibits experimental arthritis

Vascular endothelial cells (VECs) form the walls of blood vessels and play a critical role in inflammation.

4 Apr 2006

New clinical trial to test different strengths of a vaccine designed to fight avian influenza

The Duke study is part of a multicenter trial that will test a modified form of an investigational bird flu vaccine to determine whether the vaccine still triggers a strong immune response at lower doses.

4 Apr 2006

Immune response protects against brain tumor development

In their quest to determine whether immune system surveillance guards against brain tumor development, researchers at The University of Texas M. D. Anderson Cancer Center have found that allergies and asthma that stimulate inflammation may be protective, but use of antihistamines to control the inflammation could eliminate that protection.

4 Apr 2006

Gene key to infection-fighting immune cells identified

Every time the human body encounters a virus, bacteria or other infectious agent, immune cells called B-lymphocytes multiply in lymph nodes and then swing into action to fight off the intruders.

3 Apr 2006

Omega-3 fatty acids inhibit the growth of liver cancer cells

Two new studies by a University of Pittsburgh research team suggest that omega-3 fatty acids - substances that are found in high concentrations in fish oils and certain seeds and nuts - significantly inhibit the growth of liver cancer cells.

3 Apr 2006

Laughter is the best medicine

There's no doubt that laughter feels good, but is there real neurophysiology behind it and what can you do about it?

3 Apr 2006

Expecting enough bird flu vaccine for everyone is a big ask

According to researchers an experimental vaccine produced to offer protection against the H5N1 strain of bird flu presently causing havoc across the world, only appears to work at the very highest doses.

31 Mar 2006

GlaxoSmithKline announces start of clinical trials to test two pandemic vaccines against the H5N1

GlaxoSmithKline has announced the start of an international clinical trial program to test two pandemic vaccines against the H5N1 strain of the avian influenza virus in humans. This dual approach reflects the company's commitment to provide health authorities with concrete options to face the threat of a pandemic.

30 Mar 2006