Chromosome 4 News and Research

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Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 4, one copy inherited from each parent, form one of the pairs. Chromosome 4 spans more than 191 million DNA building blocks (base pairs) and represents more than 6 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 4 likely contains between 1,300 and 1,600 genes.

Genes on chromosome 4 are among the estimated 20,000 to 25,000 total genes in the human genome.

Second-line bosutinib offers ‘durable’ response for chronic phase CML patients

Four-year results for an ongoing study of second-line bosutinib indicate that the tyrosine kinase inhibitor offers long-term efficacy with manageable side effects for patients with chronic phase chronic myeloid leukaemia.

27 Nov 2015

Specific environmental influences can neutralize effect of genetic variant that increases childhood asthma risk

The effect of a widespread genetic variant that increases the risk for childhood asthma can be neutralized. A new study shows that young infants are particularly responsive to the positive influence of exposure to farm dust.

27 Nov 2015

Rutgers research reveals mechanism to prevent benign kidney tumor from becoming cancerous

Research from investigators at Rutgers Cancer Institute of New Jersey examining the inner workings of a rare non-cancerous (benign) kidney tumor has revealed a mechanism to prevent this type of tumor from becoming cancerous (malignant).

22 Nov 2015

FEC recognizes Rachel S. Weinerman for receiving 2015 Scientific Program Prize Paper Award

The Foundation for Embryonic Competence is pleased to recognize Dr. Rachel S. Weinerman, a clinical assistant professor, reproductive endocrinology and infertility at University Hospitals Case Medical in Cleveland, for receiving the 2015 Scientific Program Prize Paper Award at the 71st Annual American Society for Reproductive Medicine conference in Baltimore, Maryland on October 21, 2015.

12 Nov 2015

New method may extend use of noninvasive prenatal testing to detect chromosomal abnormalities

Researchers at the University of California, San Diego School of Medicine developed a method to expand the types of chromosomal abnormalities that noninvasive prenatal testing (NIPT) can detect. The study, published November 9 by Proceedings of the National Academy of Sciences, uses a semiconductor sequencing platform to identify small chromosomal deletions or duplications, such as occur in Cri du Chat Syndrome and DiGeorge Syndrome, with a simple blood test from the expectant mother.

10 Nov 2015

Two studies explore potential new blood tests for Alzheimer's disease

There is increasing evidence that the brain changes of Alzheimer's disease begin decades before memory and thinking problems occur, prompting the need for better methods of early detection for this progressive, fatal brain disease. Consequently, there is a growing school of thought that the most effective future Alzheimer's drug therapies will be administered to those who are at high risk of the disease before cognitive symptoms appear.

10 Nov 2015

Urinary biomarkers for bladder cancer diagnosis fall short of mark

Authors of a meta-analysis question the accuracy of urinary biomarkers for diagnosing the initial incidence or recurrence of bladder cancer.

4 Nov 2015

Patients with Down syndrome face additional challenge of early-onset dementia

Individuals with Down syndrome who survive into adulthood face the additional challenge of early-onset dementia, in which toxic amyloid plaques build up in the brain. The condition is strikingly similar to Alzheimer's disease, and as new work led by researchers at the Lewis Katz School of Medicine at Temple University shows, dementia in Down syndrome involves defects in a regulatory enzyme known as γ-secretase activating protein (GSAP), which also happens to malfunction in Alzheimer's disease.

3 Nov 2015

Rice scientists solve long-standing mystery about hemophilia protein

Rice University scientists have solved a long-standing mystery about where the body stores and deploys blood-clotting factor VIII, a protein that about 80 percent of hemophiliacs cannot produce due to genetic defects.

3 Nov 2015

New method helps study chaotic genomes of cancer cells more precisely than ever before

Scientists of the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg have developed a method for analysing the genome of cancer cells more precisely than ever before.

31 Oct 2015

Resistance to CD19 CAR T-cell therapy can be caused by CD19 splicing alterations

Resistance to CD19 CAR T-cell therapy, a type of immunotherapy that yields long-lasting remissions in many patients with B-cell leukemia, can be caused by CD19 splicing alterations, leading to loss of certain parts of the CD19 protein that are recognized by the CAR T cells.

31 Oct 2015

Nuclear membrane fixes potentially fatal breaks in DNA strands

Scientists have found a new function of the nuclear membrane, the envelope that encases and protects DNA in the nucleus of a cell - it fixes potentially fatal breaks in DNA strands.

31 Oct 2015

Researchers develop new growth charts for U.S. children with Down syndrome

Pediatric researchers have developed the first set of growth charts for U.S. children with Down syndrome since 1988. These new charts provide an important tool for pediatricians to evaluate growth milestones for children and adolescents with this condition. With these new charts, pediatricians will be able to compare each patient's growth patterns with peers of the same age and sex who have Down syndrome.

28 Oct 2015

Study uncovers new genetic variants linked to increased risk of testicular cancer

A new study of more than 25,000 men has uncovered four new genetic variants associated with increased risk of testicular cancer.

27 Oct 2015

DNA study reveals basic principle of gene regulation

A study of where and how an enzyme cuts DNA may have inadvertently revealed a basic principle of gene regulation, say researchers in Boston Children's Hospital's Program in Cellular and Molecular Medicine (PCMM).

23 Oct 2015

Active nuclear deformations contribute to formation of intra-nuclear chromosome architectures

There are two types of chromatin, euchromatin and heterochromatin, that vary with the stages of the cell cycle. In particular, euchromatin with rich active genes localizes to the interior of the nucleus during interphase; heterochromatin usually localizes to the periphery of the nucleus.

20 Oct 2015

New genetic discovery could lead to better treatment for X-linked diseases

Think back to middle school biology class, when you learned that boys have an X and a Y chromosome inside each cell, and girls have two X's.

20 Oct 2015

New UCL study highlights genes associated with schizophrenia and obesity

Genes involved in schizophrenia and obesity have been highlighted in a new UCL study, which could lead to a better understanding of the DNA variants which affect risk of these conditions and aid the development of improved strategies for prevention and treatment.

18 Oct 2015

Only few doctors refer children with developmental delays to genetics specialists, say researchers

A nine-month-old boy isn't rolling over, reaching for objects or babbling as he should be. One step his doctor won't likely take right away: have him evaluated by a genetics specialist.

15 Oct 2015

Penn researchers show that canine X-linked retinitis pigmentosa can be cured over the long term

Three years ago, a team from the University of Pennsylvania announced that they had cured X-linked retinitis pigmentosa, a blinding retinal disease, in dogs. Now they've shown that they can cure the canine disease over the long term, even when the treatment is given after half or more of the affected photoreceptor cells have been destroyed.

13 Oct 2015

Chromosome 4 News and Research

Further Reading

Second-line bosutinib offers ‘durable’ response for chronic phase CML patients

Specific environmental influences can neutralize effect of genetic variant that increases childhood asthma risk

Rutgers research reveals mechanism to prevent benign kidney tumor from becoming cancerous

FEC recognizes Rachel S. Weinerman for receiving 2015 Scientific Program Prize Paper Award

New method may extend use of noninvasive prenatal testing to detect chromosomal abnormalities

Two studies explore potential new blood tests for Alzheimer's disease

Urinary biomarkers for bladder cancer diagnosis fall short of mark

Patients with Down syndrome face additional challenge of early-onset dementia

Rice scientists solve long-standing mystery about hemophilia protein

New method helps study chaotic genomes of cancer cells more precisely than ever before

Resistance to CD19 CAR T-cell therapy can be caused by CD19 splicing alterations

Nuclear membrane fixes potentially fatal breaks in DNA strands

Researchers develop new growth charts for U.S. children with Down syndrome

Study uncovers new genetic variants linked to increased risk of testicular cancer

DNA study reveals basic principle of gene regulation

Active nuclear deformations contribute to formation of intra-nuclear chromosome architectures

New genetic discovery could lead to better treatment for X-linked diseases

New UCL study highlights genes associated with schizophrenia and obesity

Only few doctors refer children with developmental delays to genetics specialists, say researchers

Penn researchers show that canine X-linked retinitis pigmentosa can be cured over the long term

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