Signaling Pathway News and Research

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Researchers looking at ways to target lingering cancer stem cells that cause disease relapse

Chemotherapy treatment targets and kills cancer cells in the body. However, even after treatment, some cancer cells may remain in the patient's system undetected.

2 Mar 2017

Researchers to examine link between zinc deficiency, Hedgehog, and prostate cancer

Experiments show that Hedgehog signaling - a chain of molecular events critical in embryonic development - creates conditions beneficial to the unregulated cell growth associated with cancer in adults.

28 Feb 2017

Researchers discover promising target for treatment of leishmaniasis

Each year, about 2 million people contract leishmaniasis, a parasitic disease transmitted by the bite of a sand fly. The cutaneous form of the disease results in disfiguring skin ulcers that may take months or years to heal and in rare cases can become metastatic, causing major tissue damage.

24 Feb 2017

Pitt researchers uncover genetic marker that may predict drug response in many cancer types

Researchers at the University of Pittsburgh School of Medicine have uncovered a novel genetic mechanism of thyroid cancer, as well as a marker that may predict response to a particular class of drugs, not just in patients with thyroid cancer, but in those with many other types of cancer as well.

21 Feb 2017

Cancer cells adapt nerve cell mechanisms to fuel aggressive tumor growth and spread

How we think and fall in love are controlled by lightning-fast electrochemical signals across synapses, the dynamic spaces between nerve cells. Until now, nobody knew that cancer cells can repurpose tools of neuronal communication to fuel aggressive tumor growth and spread.

21 Feb 2017

Researchers discover new pathway that may play key role in kidney transplant rejection

Researchers have identified a new pathway that likely plays an important role in rejection following kidney transplantation.

17 Feb 2017

Testing treatments for bone cancer may get easier with enhanced 3D-printed scaffolds

Testing treatments for bone cancer tumors may get easier with new enhancements to sophisticated support structures that mimic their biological environment, according to Rice University scientists.

9 Feb 2017

Mutated genes lead to tooth enamel defects that increase risk of caries

Bacteria are not the sole cause of caries; tooth resistance also plays an instrumental role. Researchers from the University of Zurich demonstrate that mutated genes lead to defects in the tooth enamel and can therefore encourage the development of caries.

7 Feb 2017

Penn scientists discover clues that could lead novel therapies for preventing heart failure

Of the more than 700,000 Americans who suffer a heart attack each year, about a quarter go on to develop heart failure.

7 Feb 2017

Medical experts issue new clinical guidelines for managing and treating short children

When is it appropriate to treat short children with growth hormone? The answer is not always clear-cut, as many parents and physicians have discovered over the past three decades.

25 Jan 2017

TGen scientists identify potent inhibitory compound for treatment against glioblastoma

A study led by scientists at the Translational Genomics Research Institute has identified "a potent inhibitory compound" in the elusive hunt for an improved treatment against glioblastoma, the most common and deadly type of adult brain cancer.

18 Jan 2017

Blocking molecular signaling pathway could prevent or reverse peripheral neuropathy

Researchers at University of California San Diego School of Medicine, with colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases, the University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre in Canada, have identified a molecular signaling pathway that, when blocked, promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy-induced neuropathy and HIV.

18 Jan 2017

Researchers move one step closer to regenerating heart wall using stem cells

A process using human stem cells can generate the cells that cover the external surface of a human heart -- epicardium cells -- according to a multidisciplinary team of researchers.

12 Jan 2017

Research findings on sweat glands have potential to improve methods for culturing skin grafts

As early humans shed the hairy coats of their closest evolutionary ancestors, they also gained a distinct feature that would prove critical to their success: a type of sweat gland that allows the body to cool down quickly. Those tiny glands are enormously useful, allowing us to live in a wide variety of climates, and enabling us to run long distances.

4 Jan 2017

Physical inactivity in obese mice linked to dopamine signaling defects

Starting a regular program at the gym is a common New Year's resolution, but it's one that most people are unable to stick with for very long.

30 Dec 2016

Phase I study of selumetinib drug shows partial response in pediatric neural tumors

In an early-phase clinical trial of a new oral drug, selumetinib, children with the common genetic disorder neurofibromatosis type 1 (NF1) and plexiform neurofibromas, tumors of the peripheral nerves, tolerated selumetinib and, in most cases, responded to it with tumor shrinkage.

29 Dec 2016

Generative AAE can be radically new way to discover drugs on demand

Scientists at the Pharmaceutical Artificial Intelligence group of Insilico Medicine, Inc, today announced the publication of a seminal paper demonstrating the application of generative adversarial autoencoders (AAEs) to generating new molecular fingerprints on demand.

22 Dec 2016