Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Level of selenium-containing proteins in the body instrumental in preventing cancer

Selenium, an essential dietary mineral that can act as an antioxidant when incorporated into proteins, has been shown in many studies to reduce the incidence of cancers -- notably lung, colorectal and prostate.

23 May 2006

First animal model that mimics human head and neck cancer

An Oregon Health & Science University Cancer Institute research laboratory has developed a novel mouse model designed specifically to study the often devastating head and neck squamous cell cancers.

16 May 2006

Neurons can produce Alzheimer's-linked apolipoprotein E

A question long debated among Alzheimer's disease researchers has been definitively answered by scientists at the Gladstone Institute of Neurological Disease in San Francisco.

10 May 2006

Aggressive cancer treated successfully in mice

White blood cells from a strain of cancer-resistant mice cured advanced cancers in ordinary laboratory mice, researchers at Wake Forest University School of Medicine reported.

9 May 2006

Autopsy study of mild cognitive impairment

A study led by Mayo Clinic demonstrates that mild cognitive impairment, a memory disorder considered a strong early predictor of Alzheimer's disease, not only results in behavioral symptoms, but also structural changes that can be identified in the brain. Findings will be published in the May issue of Archives of Neurology.

9 May 2006

Advancing nanoparticle-based imaging and therapy of brain cancer

Brain cancer is one of the most difficult malignancies to detect and treat, in large part because of the difficulty in getting imaging and therapeutic agents past the so-called blood-brain barrier and into the brain.

9 May 2006

Lipoxin A4 regulates bronchial epithelial cell responses to acid injury

Doctors are gaining new leverage in the fight against lung injury caused by acid reflux. The paper by Bonnans et al., "Lipoxin A4 regulates bronchial epithelial cell responses to acid injury," appears in the April issue of The American Journal of Pathology and is accompanied by a commentary.

3 May 2006

Epstein reviews recommendations for rebiopsy in patients with high grade pin or atypical foci in prostate biopsy

In the era before extended biopsy schemes, patients with prostate biopsy results showing high grade prostatic intraepithelial neoplasia were recommended for re-biopsy in 3 to 6 months.

2 May 2006

Tumour specific drugs may render therapies based on a tumor's anatomical location obsolete

The results of a new study at Washington University School of Medicine in St. Louis could eventually have oncologists removing their specialties from their shingles by making therapy based on a tumor's anatomical location obsolete.

28 Apr 2006

Friends and family can protect against Alzheimer's disease

Having close friends and staying in contact with family members offers a protective effect against the damaging effects of Alzheimer's disease according to research by physicians at Rush University Medical Center in Chicago. The study, which is currently posted online in The Lancet Neurology, will be published in the May print edition of the journal.

26 Apr 2006

Avian flu vaccine to be developed by Mount Sinai School of Medicine and Bionostra

The Mount Sinai School of Medicine will collaborate with the prestigious Bionostra Group of Spain to develop an avian flu vaccine. The vaccine will protect against the lethal infection of the H5N1 virus.

26 Apr 2006

Blood cancers may be caused by inactivation of a "tumor suppressor" gene

The discovery of a gene, called PRDM1, as a tumor suppressor sheds new light on the cause - and possible treatment - of diffuse large B-cell lymphomas (DLBCLs), a cancer of the blood's B-lymphocytes. DLBCLs comprise about 30 percent of non-Hodgkin's lymphomas.

25 Apr 2006

Rare abdominal cancer diagnosis being looked at in a different manner

Their experience treating a rare type of abdominal cancer has helped physicians at Wake Forest University Baptist Medical Center make a new discovery that may change the way it is diagnosed.

24 Apr 2006

New finding provides researchers with renewable source for macrophages and neutrophils

A new approach to generating large quantities of two types of white blood cells that are critical for destroying invading bacteria, viruses and other pathogens in humans has been developed by researchers at the University of California, San Diego (UCSD) School of Medicine.

19 Apr 2006

First gene therapy human trial in the United States for a form of muscular dystrophy under way

The clinical trial for Duchenne muscular dystrophy (DMD) tests the safety and effectiveness of a therapy that was developed over two decades by scientists at the University of North Carolina Chapel Hill's School of Medicine and the University of Pittsburgh.

16 Apr 2006

First evidence that circulating endothelial microparticles lead to heart valve disease

Under normal physiological conditions, low levels of microparticles are continually being shed into the blood from the endothelium - the cells that line the inside of blood vessels and some organs -and appear to cause no problems.

13 Apr 2006

Environmental change and viral mutations combine to fuel outbreaks of a deadly mosquito-borne disease

Environmental change and viral mutations have combined to fuel outbreaks of a deadly mosquito-borne disease that have plagued South and Central America for the last 100 years, a new study by University of Texas Medical Branch at Galveston (UTMB) and Colorado State University researchers reports.

11 Apr 2006

Pathology News and Research

Further Reading

Level of selenium-containing proteins in the body instrumental in preventing cancer

First animal model that mimics human head and neck cancer

Neurons can produce Alzheimer's-linked apolipoprotein E

Aggressive cancer treated successfully in mice

Autopsy study of mild cognitive impairment

Advancing nanoparticle-based imaging and therapy of brain cancer

Lipoxin A4 regulates bronchial epithelial cell responses to acid injury

Epstein reviews recommendations for rebiopsy in patients with high grade pin or atypical foci in prostate biopsy

Tumour specific drugs may render therapies based on a tumor's anatomical location obsolete

Friends and family can protect against Alzheimer's disease

Avian flu vaccine to be developed by Mount Sinai School of Medicine and Bionostra

Blood cancers may be caused by inactivation of a "tumor suppressor" gene

Rare abdominal cancer diagnosis being looked at in a different manner

New finding provides researchers with renewable source for macrophages and neutrophils

First gene therapy human trial in the United States for a form of muscular dystrophy under way

First evidence that circulating endothelial microparticles lead to heart valve disease

Environmental change and viral mutations combine to fuel outbreaks of a deadly mosquito-borne disease

Research explains why recipients of growth hormone therapy may develop colon polyps

Losartan can prevent progression of Marfan syndrome

Fat cells surrounding coronary arteries may play a role in development of heart disease

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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