Chromosome 7 News and Research

RSS

Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 7, one copy inherited from each parent, form one of the pairs. Chromosome 7 spans about 159 million DNA building blocks (base pairs) and represents more than 5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 7 likely contains about 1,150 genes.

Genes on chromosome 7 are among the estimated 20,000 to 25,000 total genes in the human genome.

Active nuclear deformations contribute to formation of intra-nuclear chromosome architectures

There are two types of chromatin, euchromatin and heterochromatin, that vary with the stages of the cell cycle. In particular, euchromatin with rich active genes localizes to the interior of the nucleus during interphase; heterochromatin usually localizes to the periphery of the nucleus.

20 Oct 2015

New genetic discovery could lead to better treatment for X-linked diseases

Think back to middle school biology class, when you learned that boys have an X and a Y chromosome inside each cell, and girls have two X's.

20 Oct 2015

New UCL study highlights genes associated with schizophrenia and obesity

Genes involved in schizophrenia and obesity have been highlighted in a new UCL study, which could lead to a better understanding of the DNA variants which affect risk of these conditions and aid the development of improved strategies for prevention and treatment.

18 Oct 2015

Only few doctors refer children with developmental delays to genetics specialists, say researchers

A nine-month-old boy isn't rolling over, reaching for objects or babbling as he should be. One step his doctor won't likely take right away: have him evaluated by a genetics specialist.

15 Oct 2015

Penn researchers show that canine X-linked retinitis pigmentosa can be cured over the long term

Three years ago, a team from the University of Pennsylvania announced that they had cured X-linked retinitis pigmentosa, a blinding retinal disease, in dogs. Now they've shown that they can cure the canine disease over the long term, even when the treatment is given after half or more of the affected photoreceptor cells have been destroyed.

13 Oct 2015

YK-4-279 compound works against some forms of leukemia: Study

A compound discovered and developed by a team of Georgetown Lombardi Comprehensive Cancer Center researchers that halts cancer in animals with Ewing sarcoma and prostate cancer appears to work against some forms of leukemia, too.

12 Oct 2015

Proposed thin-plate model sheds light on structural basis of chromosomal aberrations in cancer cells

During cell division, each metaphase chromosome contains a single enormously long DNA molecule that is associated with histone proteins and forms a long chromatin filament with many nucleosomes.

9 Oct 2015

SMC5/6 protein complex plays vital role in cancer suppression and premature ageing

A study conducted by the Spanish National Cancer Research Centre´s Genomic Instability Group, led by Óscar Fernández-Capetillo, describes for the first time in mammals, the role played by the SMC5/6 protein complex in cancer suppression and premature ageing. Mutations in these complexes, which were sensitive to chemotherapeutic agents, had been previously described in yeast cells, but their exact relationship with cancer or other diseases in mammals was unknown.

8 Oct 2015

Chromosome 3q26.2 rearrangements linked to poor CML prognosis

Rearrangements of chromosome 3q26.2 have a significant negative impact on patients with chronic myeloid leukaemia, suggests research published in Blood.

1 Oct 2015

Intratumoral morphological diversity of breast cancer not related to chromosome aberrations

Intratumor morphological heterogeneity (diversity) of breast cancer is not related to chromosome aberrations. This conclusion was made based on the study of one case with aggressive variant of breast cancer - invasive micropapillary carcinoma by researchers from Tomsk State University, Tomsk Cancer Research Institute, and Institute of Medical Genetics.

30 Sep 2015

UK Biobank genetic study shows link between lung disease and smoking behaviour

New research published in The Lancet Respiratory Medicine and presented at this year's European Respiratory Society meeting in Amsterdam presents the first analyses of genetic data from the UK Biobank that reveal new associations with lung disease and smoking behaviour.

28 Sep 2015

Researchers find mutated gene responsible for cardiac angiosarcoma in two brothers

A few years ago, Javier Benítez, director of the Human Genetics Group at the CNIO, received a call from Pablo García Pavía, from the Cardiology Unit of the Puerta de Hierro University Hospital. This cardiologist was treating two brothers with a rare form of cancer, cardiac angiosarcoma (CAS).

26 Sep 2015

Amgen gets positive CHMP opinions for Kyprolis (carfilzomib) and BLINCYTO (blinatumomab)

"We are pleased to receive positive CHMP opinions for Kyprolis and BLINCYTO as this is an important step in providing new treatment options for patients in Europe with rare forms of cancer," said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen.

25 Sep 2015

Protein-coding gene identified as tumor suppressor for acute myeloid leukemia

A protein-coding gene called hnRNP K has been identified as a tumor suppressor for acute myeloid leukemia (AML), a finding that could be important for investigating how best to target treatment of a blood cancer striking mostly older individuals.

24 Sep 2015

Study uses genome- and epigenome-editing tools to determine disease-causing variants

A paper receiving advance online release in Nature Medicine describes a strategy for meeting one of today's most significant challenges in genomic medicine - determining whether a specific DNA variant in the non-protein-coding genome is the actual disease-causing variant of an associated disease risk.

24 Sep 2015

MIT researchers devise new system to genetically engineer viruses to combat harmful bacteria

In the hunt for new ways to kill harmful bacteria, scientists have turned to a natural predator: viruses that infect bacteria. By tweaking the genomes of these viruses, known as bacteriophages, researchers hope to customize them to target any type of pathogenic bacteria.

23 Sep 2015

Protein-based modular system could help detect viral infection or kill cancer cells

MIT biological engineers have developed a modular system of proteins that can detect a particular DNA sequence in a cell and then trigger a specific response, such as cell death.

22 Sep 2015

Thomas Jefferson University provides routine genomic fingerprinting to cancer patients

Cancer medicine is moving towards understanding what drives each particular patient's cancer. But not every patient has had access to this level of individualized care.

18 Sep 2015

Study confirms pathogenic role of beta amyloid in dementia as seen in AD and Down syndrome

More than five million Americans are living with Alzheimer's disease (AD). Of them, 400,000 also have Down syndrome. Both groups have similar looking brains with higher levels of the protein beta amyloid.

18 Sep 2015

Researchers identify triple mechanism that prevents onset of chromosomal instability

Universitat Autònoma de Barcelona researchers have identified for the first time the triple mechanism that stops chromosome separation in response to situations that compromise the integrity of the genetic information. The loss of this response capacity is characteristic of cancerous cells.

18 Sep 2015

Chromosome 7 News and Research

Active nuclear deformations contribute to formation of intra-nuclear chromosome architectures

New genetic discovery could lead to better treatment for X-linked diseases

New UCL study highlights genes associated with schizophrenia and obesity

Only few doctors refer children with developmental delays to genetics specialists, say researchers

Penn researchers show that canine X-linked retinitis pigmentosa can be cured over the long term

YK-4-279 compound works against some forms of leukemia: Study

Proposed thin-plate model sheds light on structural basis of chromosomal aberrations in cancer cells

SMC5/6 protein complex plays vital role in cancer suppression and premature ageing

Chromosome 3q26.2 rearrangements linked to poor CML prognosis

Intratumoral morphological diversity of breast cancer not related to chromosome aberrations

UK Biobank genetic study shows link between lung disease and smoking behaviour

Researchers find mutated gene responsible for cardiac angiosarcoma in two brothers

Amgen gets positive CHMP opinions for Kyprolis (carfilzomib) and BLINCYTO (blinatumomab)

Protein-coding gene identified as tumor suppressor for acute myeloid leukemia

Study uses genome- and epigenome-editing tools to determine disease-causing variants

MIT researchers devise new system to genetically engineer viruses to combat harmful bacteria

Protein-based modular system could help detect viral infection or kill cancer cells

Thomas Jefferson University provides routine genomic fingerprinting to cancer patients

Study confirms pathogenic role of beta amyloid in dementia as seen in AD and Down syndrome

Researchers identify triple mechanism that prevents onset of chromosomal instability

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Exploring the G:Box and for high-quality imaging

Latest News