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Antibody-based molecular imaging agent offers hope for novel breast cancer treatments

For years researchers have been developing molecular imaging techniques that visualize hormonally active breast cancer cells-specifically those testing positive for human epidermal growth factor receptor 2 (HER2).

10 Jun 2014

Scientists unravel how herpesviruses fight against our immune system

How the virus does this was unknown until now. The scientists from the HZI research group "Viral Immune Modulation" under the leadership of Prof. Melanie Brinkmann have now been able to show that the virus is actively preventing activation of the innate immune system through Toll-like receptors.

9 Jun 2014

Scientists develop new molecule for monitoring drug concentration

Monitoring the drug concentration in patients is critical for effective treatment, especially in cases of cancer, heart disease, epilepsy and immunosuppression after organ transplants.

9 Jun 2014

Researchers uncover several gene networks with potentially important roles in autism

A large new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism.

9 Jun 2014

Tiny molecule may provide marker for depression

Levels of a small molecule found only in humans and in other primates are lower in the brains of depressed individuals, according to researchers at McGill University and the Douglas Institute.

9 Jun 2014

New targets could increase effectiveness and reduce side effects linked with breast cancer treatments

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found new targets for potential intervention in breast cancer. These new targets could eventually increase effectiveness and reduce the undesirable side effects associated with current treatments.

6 Jun 2014

Gene networks may offer attractive targets for developing new autism drugs

A large new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism.

6 Jun 2014

Endocrine Society announces winners of Early Investigators Awards and FLARE Internship Awards

The Endocrine Society is pleased to announce the recipients of the 2014 Early Investigators Awards and the Future Leaders Advancing Research in Endocrinology Internship Awards.

6 Jun 2014

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

St. Jude Children's Research Hospital scientists have identified problems in a connection between brain structures that may predispose individuals to hearing the "voices" that are a common symptom of schizophrenia. The work appears in the June 6 issue of the journal Science.

6 Jun 2014

New targets found for potential intervention in breast cancer

Scientists from the Florida campus of The Scripps Research Institute have found new targets for potential intervention in breast cancer. These new targets could eventually increase effectiveness and reduce the undesirable side effects associated with current treatments.

6 Jun 2014

Discovery may lead to relief for victims of range of neurological disorders

University of Toronto biologists leading an investigation into the cells that regulate proper brain function, have identified and located the key players whose actions contribute to afflictions such as epilepsy and schizophrenia.

6 Jun 2014

Naloxegol holds hope for opioid-induced constipation

Pain medicines often lead to constipation for patients seeking long-term pain relief, but an investigational once-daily drug may help, according to study led by the University of Michigan Health System.

5 Jun 2014

$SAGE reports preliminary data from SAGE-547 Phase 1/2 clinical trial for super-refractory status epilepticus$

SAGE reports preliminary data from SAGE-547 Phase 1/2 clinical trial for super-refractory status epilepticus

SAGE Therapeutics, a biopharmaceutical company developing novel medicines to treat life-threatening, rare central nervous system (CNS) disorders, today announced preliminary data from its ongoing open-label Phase 1/2 clinical trial of SAGE-547, an allosteric modulator of GABAA receptors, in patients with super-refractory status epilepticus (SRSE).

5 Jun 2014

Macrophages present in shed endometrium may contribute to lesion formation, shows study

A mouse model of endometriosis has been developed that produces endometriosis lesions similar to those found in humans, according to a report published in The American Journal of Pathology.

5 Jun 2014

Interferon Type I immune proteins key drivers of human hemorrhagic fevers

Hemorrhagic fevers caused by Lassa, dengue and other viruses affect more than one million people annually and are often fatal, yet scientists have never understood why only some virus-infected people come down with the disease and others do not.

5 Jun 2014

Neuroscientists explain how miswiring in brain area can potentially contribute to ADHD

Neuroscientists at Mayo Clinic in Florida and at Aarhus University in Denmark have shed light on why neurons in the brain's reward system can be miswired, potentially contributing to disorders such as attention deficit hyperactivity disorder (ADHD).

5 Jun 2014

Synthetic peptide carrier delivers drugs through blood-brain barrier for cancer treatment

Researchers at Mayo Clinic have demonstrated in a mouse model that their recently developed synthetic peptide carrier is a potential delivery vehicle for brain cancer chemotherapy drugs and other neurological medications. The findings appear in PLOS ONE.

4 Jun 2014

Leukemia researcher wins 2014 Taubman Prize for Excellence in Translational Medical Science

A physician-scientist who developed a personalized immunotherapy for leukemia using patients' own T cells is the recipient of the 2014 Taubman Prize for Excellence in Translational Medical Science, awarded by the A. Alfred Taubman Medical Research Institute at the University of Michigan Medical School.

4 Jun 2014

Interaction of stress and taste systems could help explain stress-related eating

According to new research from the Monell Center, receptors for stress-activated hormones have been localized in oral taste cells responsible for detection of sweet, umami, and bitter. The findings suggest that these hormones, known as glucocorticoids, may act directly on taste receptor cells under conditions of stress to affect how these cells respond to sugars and certain other taste stimuli.

4 Jun 2014

New vaccine effective at preventing lung cancer in mice

Tweaking a protein expressed by most liver cancer cells has enabled scientists to make a vaccine that is exceedingly effective at preventing the disease in mice.

4 Jun 2014

Receptor News and Research

Antibody-based molecular imaging agent offers hope for novel breast cancer treatments

Scientists unravel how herpesviruses fight against our immune system

Scientists develop new molecule for monitoring drug concentration

Researchers uncover several gene networks with potentially important roles in autism

Tiny molecule may provide marker for depression

New targets could increase effectiveness and reduce side effects linked with breast cancer treatments

Gene networks may offer attractive targets for developing new autism drugs

Endocrine Society announces winners of Early Investigators Awards and FLARE Internship Awards

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

New targets found for potential intervention in breast cancer

Discovery may lead to relief for victims of range of neurological disorders

Naloxegol holds hope for opioid-induced constipation

SAGE reports preliminary data from SAGE-547 Phase 1/2 clinical trial for super-refractory status epilepticus

Macrophages present in shed endometrium may contribute to lesion formation, shows study

Interferon Type I immune proteins key drivers of human hemorrhagic fevers

Neuroscientists explain how miswiring in brain area can potentially contribute to ADHD

Synthetic peptide carrier delivers drugs through blood-brain barrier for cancer treatment

Leukemia researcher wins 2014 Taubman Prize for Excellence in Translational Medical Science

Interaction of stress and taste systems could help explain stress-related eating

New vaccine effective at preventing lung cancer in mice

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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