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Inflammation may accentuate age-related bladder function decline

Age-associated biochemical changes in the bladder may accentuate the inflammation associated with overactive bladder, study findings indicate.

12 May 2014

Researchers reveal how protein acts as brake against pathological growth of heart muscle

Cardiovascular disease remains the number one cause of death in the Western world, with heart failure representing the fastest-growing subclass over the past decade.

12 May 2014

Shift switches pain sensor from cold-sensitive to hot-sensitive

Ice cream lovers and hot tea drinkers with sensitive teeth could one day have a reason to celebrate a new finding from Duke University researchers. The scientists have found a very small change in a single protein that turns a cold-sensitive receptor into one that senses heat.

9 May 2014

Chinese herbal formula protects against hippocampal neurons death via non-classical estrogen pathway

Amyloid-β (Aβ) plaques and neurofibrillary tangles are the main pathological hallmarks of Alzheimer's disease, as well as the loss of neurons and synapses. recent reports have shown that estrogen exerts neuroprotective effects.

9 May 2014

Salix Pharmaceuticals' total net product revenue increases 90% to $384.4 million in Q1 2014

Salix Pharmaceuticals, Ltd. today announced financial and operating results for the first quarter ended March 31, 2014, and other business updates.

9 May 2014

New study associates sex difference in brain with MS

A newly identified difference between the brains of women and men with multiple sclerosis (MS) may help explain why so many more women than men get the disease, researchers at Washington University School of Medicine in St. Louis report.

9 May 2014

TAG-1 induces apoptosis-related gene expression without triggering apoptosis in glioma cells

A recent study reported by Haigang Chang and co-workers from the First Affiliated Hospital of Xinxiang Medical University in China verified the effects of transient axonal glycoprotein-1 (TAG-1) on cell viability and p53, epidermal growth factor receptor (EGFR), and amyloid precursor protein (APP) intracellular C-terminal domain (AICD) expression in U251 glioma cells.

8 May 2014

Ambrisentan cleared for use with phenprocoumon

Starting treatment with ambrisentan does not necessitate adjusting the dose of the oral anticoagulant phenprocoumon in patients with pulmonary hypertension who require both medications, report researchers.

7 May 2014

Ligand's total revenues increase 37% to $16.0 million in first quarter 2014

Ligand Pharmaceuticals Incorporated today reported financial results for the three months ended March 31, 2014, and provided an operating forecast and program updates.

7 May 2014

NanoString receives license from Health Canada to market Prosigna Breast Cancer Prognostic Gene Signature Assay

NanoString Technologies, Inc., a provider of life science tools for translational research and molecular diagnostic products, today announced that it has received a Class III Medical Device License from Health Canada, clearing the company to market its Prosigna Breast Cancer Prognostic Gene Signature Assay for assessing a woman's 10-year risk of distant recurrence and accurately identifying the intrinsic biologic subtype of the tumor.

From NanoString Technologies 7 May 2014

Rice University researchers find new possibilities for benign, 'tunable' virus

Rice University scientists have designed a tunable virus that works like a safe deposit box. It takes two keys to open it and release its therapeutic cargo.

7 May 2014

FDA accepts Merck's MK-3475 BLA for review

Merck, known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration has accepted for review the Biologics License Application (BLA) for MK-3475, Merck's investigational anti-PD-1 antibody, for the treatment of unresectable or metastatic melanoma in patients who have been previously treated with ipilimumab.

6 May 2014

New approach for auditory localization of patients with hearing aids under background noise

Patients with implanted artificial cochlea often complain that they cannot recognize speech well in natural environments, especially if background of noise is present.

6 May 2014

Naurex's two lead antidepressant programs achieve major milestones

Naurex Inc., a privately held biopharmaceutical company leveraging its unique platform to develop novel drugs for diseases of the central nervous system (CNS), today announced that its two lead antidepressant programs achieved major milestones.

6 May 2014

Nanoviricides develops new drug candidates against MERS infection

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6 May 2014

Phosphate linked to cause high blood pressure and heart disease

Researchers find link between phosphate rich foods and an enzyme linked to cardiovascular disease. The findings also link phosphates to renal disease.

6 May 2014

UH biomedical engineer receives ALR grant to study cause of lupus nephritis

In the U.S. alone, more than 1.5 million people have lupus, a chronic autoimmune disease in which the immune system turns against itself, attacking a person's healthy tissue, cells and organs. The symptoms can range from debilitating pain and fatigue to organ failure.

6 May 2014

Higher sleep efficiency in women with advanced breast cancer is associated with lower mortality

A new study reports that sleep efficiency, a ratio of time asleep to time spent in bed, is predictive of survival time for women with advanced breast cancer.

5 May 2014

TSRI scientists identify molecular pathways that resveratrol uses to achieve beneficial action

Resveratrol has been much in the news as the component of grapes and red wine associated with reducing “bad cholesterol,” heart disease and some types of cancer. Also found in blueberries, cranberries, mulberries, peanuts and pistachios, resveratrol is associated with beneficial health effects in aging, inflammation and metabolism.

30 Apr 2014

Scientific data confirms therapeutic potential of Anavex's S1R agonist against Parkinson’s disease

Anavex Life Sciences Corp., a clinical stage biopharmaceutical company developing novel drug candidates to treat Alzheimer’s, other diseases of the central nervous system (CNS) and various types of cancer, today announced the findings of a research study published in the current issue of peer-reviewed scientific journal Brain.

30 Apr 2014

Receptor News and Research

Inflammation may accentuate age-related bladder function decline

Researchers reveal how protein acts as brake against pathological growth of heart muscle

Shift switches pain sensor from cold-sensitive to hot-sensitive

Chinese herbal formula protects against hippocampal neurons death via non-classical estrogen pathway

Salix Pharmaceuticals' total net product revenue increases 90% to $384.4 million in Q1 2014

New study associates sex difference in brain with MS

TAG-1 induces apoptosis-related gene expression without triggering apoptosis in glioma cells

Ambrisentan cleared for use with phenprocoumon

Ligand's total revenues increase 37% to $16.0 million in first quarter 2014

NanoString receives license from Health Canada to market Prosigna Breast Cancer Prognostic Gene Signature Assay

Rice University researchers find new possibilities for benign, 'tunable' virus

FDA accepts Merck's MK-3475 BLA for review

New approach for auditory localization of patients with hearing aids under background noise

Naurex's two lead antidepressant programs achieve major milestones

Nanoviricides develops new drug candidates against MERS infection

Phosphate linked to cause high blood pressure and heart disease

UH biomedical engineer receives ALR grant to study cause of lupus nephritis

Higher sleep efficiency in women with advanced breast cancer is associated with lower mortality

TSRI scientists identify molecular pathways that resveratrol uses to achieve beneficial action

Scientific data confirms therapeutic potential of Anavex's S1R agonist against Parkinson’s disease

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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