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Researchers discover two signaling pathways that are downregulated in human hearts after birth

Published today in Stem Cell Reports, researchers from the University of Minnesota Medical School discovered two signaling pathways that are downregulated in human hearts after birth.

4 Aug 2022

UAB researchers report a potential treatment for ARID1A-deficient bladder cancer

Metastatic bladder cancer is generally incurable, so new therapies are an urgent need. Researchers at the University of Alabama at Birmingham now report a potential treatment for a quarter of bladder cancers.

4 Aug 2022

Twitter scraping tool reveals an “infodemic” of misinformation during the first year of COVID pandemic

More than 225,000 tweets with the hashtags #scamdemic and #plandemic led to an "infodemic" of misinformation and disinformation on Twitter during the first year of the pandemic, according to a study by UT Southwestern researchers published in PLOS ONE.

4 Aug 2022

Researchers uncover genomic characteristics of breast cancers associated with PTEN hamartoma tumor syndrome

Cleveland Clinic researchers have uncovered genomic characteristics of breast cancers associated with PTEN hamartoma tumor syndrome (PHTS) that differentiate them from sporadic breast cancers.

4 Aug 2022

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Although Aduhelm, a monoclonal antibody targeting amyloid beta (Aβ), recently became the first US FDA approved drug for Alzheimer's disease (AD) based on its ability to decrease Aβ plaque burden in AD patients, its effect on cognitive improvement is still controversial.

4 Aug 2022

Mitochondrial DNA mutations are associated with an increased risk of atherosclerosis

Mitochondria are organelles found within most cells, best known for generating the chemical energy required to power cellular functions.

4 Aug 2022

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Residing within the human gut are trillions of bacteria and other microorganisms that can impact a variety of chronic human ailments, including obesity, type 2 diabetes, atherosclerosis, cancer, non-alcoholic fatty liver disease and inflammatory bowel disease.

4 Aug 2022

Johns Hopkins Medicine-led consortium awarded up to $200 million to address the global burden of tuberculosis

To address the global burden of tuberculosis (TB), one of humankind's oldest scourges, an international collaboration led by Johns Hopkins Medicine has today been awarded up to $200 million in research funding over five years by the U.S. Agency for International Development (USAID) Supporting, Mobilizing and Accelerating Research for Tuberculosis Elimination (SMART4TB) project.

4 Aug 2022

Study highlights the urgency of removing barriers to accessing medications for opioid use disorder

The opioid overdose and death epidemic continues to worsen across the United States, but medications such as methadone, buprenorphine, and extended-release naltrexone are proven to reduce opioid overdoses by more than 50 percent.

4 Aug 2022

CHOP helps launch new computational platform to harmonize pediatric cancer data

Children's Hospital of Philadelphia has helped launch a new computational platform that will harmonize pediatric cancer data, allowing researchers, pharmaceutical companies, and advocacy groups to accelerate the pace of drug development for pediatric cancer.

4 Aug 2022

Monoclonal antibody protects U.S. adults from malaria, Phase 1 clinical trial shows

One injection of a candidate monoclonal antibody (mAb) known as L9LS was found to be safe and highly protective in U.S. adults exposed to the malaria parasite, according to results from a National Institutes of Health Phase 1 clinical trial published in The New England Journal of Medicine.

4 Aug 2022

New easy-to-use test could rapidly diagnose heart attacks and cancers

Imperial researchers have built a new easy-to-use test that could diagnose non-infectious diseases like heart attacks and cancers more quickly.

4 Aug 2022

Higher suPAR levels linked with increased risk of blood clot formation

Blood clots are thought to occur in as many as a third of patients hospitalized with COVID-19. In many cases these clots can be deadly, such as pulmonary embolisms-;blood clots that travel to the lungs. In fact, in nearly one third of patients with COVID-19, these clots led to death.

4 Aug 2022

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

We are increasingly being exposed to endocrine-disrupting chemicals (EDCs) that interfere with the normal functioning of our hormones. Bisphenol A (BPA) and phthalates, which are widely used in consumer products including plastics, aluminum cans, pharmaceuticals, and cosmetics, are well-known EDCs.

4 Aug 2022

Optical coherence tomography combined with machine learning to develop colorectal cancer imaging tool

A research team from the lab of Quing Zhu, the Edwin H. Murty Professor of Engineering in the Department of Biomedical Engineering at the McKelvey School of Engineering at Washington University in St. Louis, has combined optical coherence tomography (OCT) and machine learning to develop a colorectal cancer imaging tool that may one day improve the traditional endoscopy currently used by doctors.

4 Aug 2022

Therapeutic use of ketamine may be safe, study suggests

Commonly used in medicine as an anesthetic, ketamine is also increasingly prescribed to relieve depressive symptoms. This very fast-acting psychotropic drug is particularly indicated for the treatment of patients resistant to conventional antidepressants.

4 Aug 2022

When mental illness leads to dropped charges, patients often go without stabilizing care

For seven years, Timothy Jay Fowler rotated between jail, forced psychiatric hospitalization, and freedom.

4 Aug 2022

A California man’s ‘painful and terrifying’ road to a monkeypox diagnosis

Two days after Kevin Kwong flew home to California from New York, his hands itched so badly, the pain jolted him from sleep. He thought the problem was eczema.

4 Aug 2022

New study uncovers a likely proteome signature for reductive stress cardiomyopathy

Two years ago, University of Alabama at Birmingham researchers and colleagues reported that reductive stress -; an imbalance in the normal oxidation/reduction, or redox, homeostasis -; caused pathological changes associated with heart failure in a mouse model.

3 Aug 2022

Study: Genes involved in coronary heart disease may be nearly the same for everyone

The genes involved in coronary heart disease, the most common form of heart disease, appear to be nearly the same for everyone, according to a VA study.

3 Aug 2022

Medicine News and Research

Researchers discover two signaling pathways that are downregulated in human hearts after birth

UAB researchers report a potential treatment for ARID1A-deficient bladder cancer

Twitter scraping tool reveals an “infodemic” of misinformation during the first year of COVID pandemic

Researchers uncover genomic characteristics of breast cancers associated with PTEN hamartoma tumor syndrome

Novel fusion protein drug for Alzheimer’s disease circumvents the neurotoxic inflammatory side effects

Mitochondrial DNA mutations are associated with an increased risk of atherosclerosis

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Johns Hopkins Medicine-led consortium awarded up to $200 million to address the global burden of tuberculosis

Study highlights the urgency of removing barriers to accessing medications for opioid use disorder

CHOP helps launch new computational platform to harmonize pediatric cancer data

Monoclonal antibody protects U.S. adults from malaria, Phase 1 clinical trial shows

New easy-to-use test could rapidly diagnose heart attacks and cancers

Higher suPAR levels linked with increased risk of blood clot formation

Mice study reveals hepatic consequences of exposure to endocrine disrupting chemical mixtures

Optical coherence tomography combined with machine learning to develop colorectal cancer imaging tool

Therapeutic use of ketamine may be safe, study suggests

When mental illness leads to dropped charges, patients often go without stabilizing care

A California man’s ‘painful and terrifying’ road to a monkeypox diagnosis

New study uncovers a likely proteome signature for reductive stress cardiomyopathy

Study: Genes involved in coronary heart disease may be nearly the same for everyone

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

Automating research - solutions and best practices

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