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New drug treatment could reduce body weight in obese patients with rare genetic disorder

As part of a phase II study at Charité - Universitätsmedizin Berlin and the Berlin Institute of Health, two obese patients with a rare genetic disorder were given a drug treatment to stimulate the satiety center in the brain.

3 Aug 2016

Scientists use Regeneration Intelligence to assess perturbation status of many signaling pathways

Insilico Medicine, Inc in collaboration with scientists from Atlas Regeneration, Inc, Vision Genomics, Inc and Howard University published two research papers on fibrosis in the lung and liver and fibrotic signatures in glaucoma.

30 Jul 2016

Blood pressure hormone system important for cardiovascular health can promote obesity

New research by University of Iowa scientists helps explain how a hormone system often targeted to treat cardiovascular disease can also lower metabolism and promote obesity.

29 Jul 2016

Adding new monoclonal antibody to chemotherapy improves survival in soft-tissue sarcoma patients

Adding a novel monoclonal antibody therapy to traditional chemotherapy increased median survival by nearly a year in patients with advanced sarcoma, a lethal soft-tissue cancer.

21 Jul 2016

Immune system signaling can directly affect social behavior

Using a systems-biology approach, scientists at the University of Massachusetts Medical School made a startling discovery that immune system signaling can directly affect, and even change, social behavior in mice and other model animals.

18 Jul 2016

TUM scientists discover molecular signaling pathway for self-destruction in leukemia cells

When adults develop blood cancer, they are frequently diagnosed with what is referred to as acute myeloid leukemia.

15 Jul 2016

Expanding the potential of existing cancer therapies: an interview with Dr Mark Rutstein

Cancer remains a leading cause of death worldwide, and the global cancer burden is expected to increase by 70 percent over the next two decades.

14 Jul 2016

Food additive tBHQ may be linked to increase in food allergies

A Michigan State University researcher has found that a common food additive may be linked to a rise in food allergies.

11 Jul 2016

Transplant drug rapamycin may reduce nerve damage, neuropathic pain after spinal cord injury

New research in mice indicates that a drug commonly used to suppress the immune system in recipients of organ transplants may also reduce tissue damage and neuropathic pain after spinal cord injury. The findings are published in the Journal of Orthopaedic Research.

8 Jul 2016

Study identifies genetic mutations responsible for development of cardiac hypertrophy in adults

Investigators at Beth Israel Deaconess Medical Center have identified a developmental cause of adult-onset cardiac hypertrophy, a dangerous thickening of the heart muscle that can lead to heart failure and death.

8 Jul 2016

Study proves cells can send ephrins and Ephs out to transmit signals

Eph receptors and their partner proteins, the ephrins, are vital for intercellular communication.

8 Jul 2016

MGH researchers discover how obesity increases inflammation, desmoplasia in PDAC patients

Massachusetts General Hospital investigators have discovered the mechanism by which obesity increases inflammation and desmoplasia - an accumulation of connective tissue - in the most common form of pancreatic cancer.

7 Jul 2016

Study links proteins involved in cell division to insulin signaling

Proteins that play key roles in the timing of cell division also moonlight in regulating blood sugar levels, UT Southwestern Medical Center researchers have found.

1 Jul 2016

Mice study shows influence of dad's obesity on daughter’s body weight and breast cancer risk

Obese male mice and normal weight female mice produce female pups that are overweight at birth through childhood, and have delayed development of their breast tissue as well as increased rates of breast cancer.

24 Jun 2016

Breast cancer cells use new signaling pathway to cope with lack of oxygen levels inside tumors

Researchers have identified a new signaling pathway that helps cancer cells cope with the lack of oxygen found inside tumors. These are the results of a study published in Nature Cell Biology on June 20, and led by researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center, Princess Margaret Cancer Center, the University of Toronto, Harvard Medical School and Oxford University.

21 Jun 2016

Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

Researchers from the 'Angiogenesis signaling pathways' research group of the Institute of Biomedical Investigation of Bellvitge, led by Dr. Mariona Graupera, have unveiled the potential therapeutic benefit of a selective inhibitior of the PI3-kinase (PI3K) protein in pancreatic neuroendocrine tumors (PanNETs).

17 Jun 2016

Review sheds light on current therapeutic targets of miRNA-associated chemoresistance in EOC

Epithelial ovarian cancer (EOC) is the most lethal disease among gynecologic malignancies. Patients with an advanced disease often relapse due to the development of chemoresistance. Chemotherapy failure is a consequence of acquired drug resistance which may potentially be due to multiple mechanisms including miRNA-mediated gene regulation.

17 Jun 2016

RVFV uses cancer pathway to hijack host cell and cause infection

Viruses can't live without us -- literally. As obligate parasites, viruses need a host cell to survive and grow. Scientists are exploiting this characteristic by developing therapeutics that close off pathways necessary for viral infection, essentially stopping pathogens in their tracks.

17 Jun 2016

Scientists identify gene linked to severe glaucoma in children

Northwestern Medicine and University of Wisconsin-Madison scientists have identified a gene that causes severe glaucoma in children.

13 Jun 2016

Life Extension, Insilico Medicine team up to identify novel biomarkers of human aging

Life Extension (use different web link to highlight our technical attributes), a Florida-based organization established in the early 1980s is dedicated to extending healthy human longevity.

8 Jun 2016

Signaling Pathway News and Research

New drug treatment could reduce body weight in obese patients with rare genetic disorder

Scientists use Regeneration Intelligence to assess perturbation status of many signaling pathways

Blood pressure hormone system important for cardiovascular health can promote obesity

Adding new monoclonal antibody to chemotherapy improves survival in soft-tissue sarcoma patients

Immune system signaling can directly affect social behavior

TUM scientists discover molecular signaling pathway for self-destruction in leukemia cells

Expanding the potential of existing cancer therapies: an interview with Dr Mark Rutstein

Food additive tBHQ may be linked to increase in food allergies

Transplant drug rapamycin may reduce nerve damage, neuropathic pain after spinal cord injury

Study identifies genetic mutations responsible for development of cardiac hypertrophy in adults

Study proves cells can send ephrins and Ephs out to transmit signals

MGH researchers discover how obesity increases inflammation, desmoplasia in PDAC patients

Study links proteins involved in cell division to insulin signaling

Mice study shows influence of dad's obesity on daughter’s body weight and breast cancer risk

Breast cancer cells use new signaling pathway to cope with lack of oxygen levels inside tumors

Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

Review sheds light on current therapeutic targets of miRNA-associated chemoresistance in EOC

RVFV uses cancer pathway to hijack host cell and cause infection

Scientists identify gene linked to severe glaucoma in children

Life Extension, Insilico Medicine team up to identify novel biomarkers of human aging

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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