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Case study sheds light on CAR-T therapy-related secondary cancers

A new detailed analysis of a patient's second cancer after receiving CAR-T therapy for the initial cancer provides rare but important insights intended to offer helpful guidance for oncologists and pathologists about the clinical presentation and pathologic features involved in a CAR-T related second cancer.

13 Jun 2024

Mutated TREX1 gene linked to catastrophic DNA damage and deadly rare disease

TREX1 is a gene that is supposed to direct the maintenance of the entire body's DNA, but new research shows that when people are born with mutated TREX1, it causes catastrophic damage to the DNA over time, resulting in a deadly rare disease called retinal vasculopathy with cerebral leukoencephalopathy (RVCL).

13 Jun 2024

Multiple head injuries significantly raise ischemic stroke risk, research shows

The rate of stroke in individuals with no history of prior stroke, was 34 percent higher in individuals who experienced at least one head injury than in their peers with no head injury.

13 Jun 2024

Empowering communities: Penn Medicine's annual mammogram event and health fair

Penn Medicine will once again join with community partners and Siemens Healthineers to host a free mammogram clinic and community health fair in June, giving the West Philadelphia and Upper Darby communities convenient access to health screenings right in their neighborhoods.

13 Jun 2024

Low-sodium alternatives could have a positive impact on the Indonesian health

Excess sodium intake and a lack of potassium are major contributing factors towards high blood pressure in Indonesia, prompting calls for low-sodium potassium-rich salt substitutes (LSSS) to be readily available to improve health and curb health costs.

13 Jun 2024

New armored CAR T cell therapy boosts response in Relapsed non-Hodgkin lymphoma patients

While CAR T cell therapy has revolutionized treatment for many blood cancers, including non-Hodgkin lymphoma (NHL), many patients who receive CAR T cell therapy do not experience a long-term remission.

13 Jun 2024

AHA selects five innovators for the Heart and Brain Health Accelerator program The Amer...

The American Heart Association, through its Center for Health Technology and Innovation (the Center), has selected five companies to participate in the American Heart Association Heart and Brain Health Accelerator.

13 Jun 2024

MIT researchers develop revolutionary system for high-resolution brain imaging

A suite of three innovations by an MIT-based team enables high-resolution, high-throughput imaging of human brain tissue at a full range of scales and mapping connectivity of neurons at single cell resolution.

13 Jun 2024

Targeting basophils to revitalize cytotoxic T-cells in tumor microenvironment

The ecosystem that surrounds a tumor, also known as the tumor microenvironment, includes immune cells, tissues, blood vessels and other cells that interact with each other and with the tumor.

13 Jun 2024

Study advocates for liberal blood transfusions in TBI intensive care

Increased use of blood transfusions after major traumatic brain injury could help people hospitalized in intensive care units regain greater functional independence and a better quality of life.

13 Jun 2024

New insights into blood precursors of pathogenic macrophages in RA

The exact origin and precursor differentiation route of tissue macrophages remains controversial. At the 2024 congress of EULAR - The European Alliance of Associations for Rheumatology - new work sheds light on blood precursors of pathogenic tissue macrophages.

13 Jun 2024

Research points to a potential approach to mitigating diabetes risk from antipsychotic medications

New University of Pittsburgh research points to a potential approach to reducing the risk of diabetes associated with widely prescribed antipsychotic medications.

13 Jun 2024

Noninvasive ventilation halves hypoxemia risk in emergency intubations: PREOXI trial findings

In current clinical care, most critically ill adults undergoing emergency tracheal intubation receive preoxygenation through an oxygen mask.

13 Jun 2024

Pre-surgery GLP-1 agonists reduce post-operative risks in extreme obesity

A combination of GLP-1 agonists taken before metabolic and bariatric surgery may help patients with extreme obesity lower the risk of post-operative complications, according to a new study presented today at the American Society for Metabolic and Bariatric Surgery 2024 Annual Scientific Meeting.

13 Jun 2024

MEK inhibitor trametinib shows potential in pediatric JMML treatment

The MEK inhibitor trametinib (Mekinist) was an effective treatment for pediatric patients with relapsed or refractory juvenile myelomonocytic leukemia (JMML) enrolled in a phase II clinical trial, with seven of 10 patients alive after a median of two years.

13 Jun 2024

Study confirms no causal link between COVID-19 and ischemic priapism

A study in the International Journal of Impotence Research found no causal link between COVID-19 and ischemic priapism, with priapism occurring across all COVID-19 severity levels and treatments remaining effective.

13 Jun 2024

Study identifies drug target to prevent autonomic dysfunction after spinal cord injury

In response to stressful or dangerous stimuli, nerve cells in the spinal cord activate involuntary, autonomic reflexes often referred to as "fight or flight" responses.

12 Jun 2024

Stanford study finds low risk of secondary blood cancers after CAR-T cell therapy

A large study by researchers at Stanford Medicine has found that the risk of secondary blood cancers after CAR-T cell therapy -; a cell-based cancer treatment that exploded on the scene in 2017 as a treatment for intractable blood cancers -; is low, despite a Food and Drug Administration warning.

12 Jun 2024

Changing antibiotic delivery method improves sepsis outcomes globally

Changing the way antibiotics are given to adult patients with sepsis will save thousands of lives a year globally, according to research by The University of Queensland and The George Institute for Global Health.

12 Jun 2024

Prolonged depression in young adults linked to cognitive decline in middle age

People who experience prolonged depressive symptoms starting in young adulthood may have worse thinking and memory skills in middle age, according to a study published in the June 12, 2024, online issue of Neurology, the medical journal of the American Academy of Neurology.

12 Jun 2024