Kidney Disease News and Research

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Promising treatment does not guard against complication in type 1 diabetes

Historically, half or more of people with type 1 diabetes develop kidney disease, which frequently progresses to kidney failure requiring hemodialysis or a kidney transplant for survival.

25 Jun 2020

Tiny protein in mitochondria has a big impact on health and longevity, study shows

A new study led by researchers at the USC Leonard Davis School of Gerontology is the first to demonstrate that a tiny protein has a big impact on health and longevity in both animals and humans.

24 Jun 2020

ACE inhibition in kidney could influence pathogenesis of SARS-CoV-2

The dynamics of angiotensin-converting enzyme 2 (ACE2) expression in the kidney could have implications for the infectivity and pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), say researchers.

24 Jun 2020

Common cancer treatments do not worsen COVID-19 infection, study finds

The characterization of COVID-19 in patients with cancer remains limited in published studies and nationwide surveillance analyses.

24 Jun 2020

Striking differences found between NHS trusts in COVID-19 ICU deaths

A University of Cambridge team led by Professor Mihaela van der Schaar and intensive care consultant Dr Ari Ercole of the Cambridge Centre for AI in Medicine is calling for urgent research into the striking differences in COVID-19 deaths they have discovered between the intensive care units of NHS trusts across England.

23 Jun 2020

Study identifies new gene variants tied to type-2 diabetes

After examining the genes of more than 200,000 people all over the world who have type-2 diabetes, researchers from the Perelman School of Medicine at the University of Pennsylvania and the Veterans Health Administration's Corporal Michael J. Crescenz Veterans Affairs Medical Center found hundreds of genetic variants never before linked to the disease.

23 Jun 2020

Heart failure poses the greatest risk of death for people with type 2 diabetes

Heart failure posed the greatest 5-year risk of death for people newly diagnosed with Type 2 diabetes than any other heart or kidney disease, according to new research published today in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal.

23 Jun 2020

Clinicians can use patient data to predict life expectancy for older adults with diabetes

A new study finds that clinicians can use patient data, such as a history of co-occurring health conditions and medication, to predict the 5- and 10-year life expectancy of older people with diabetes.

19 Jun 2020

Discovery of key steps in kidney formation could have implications for treating renal diseases

The discovery of how certain key structures in the kidneys are formed could have important implications for treating renal fibrosis (or scarring), a feature of chronic kidney disease (CKD), according to a new study by a researcher at Massachusetts General Hospital.

18 Jun 2020

COVID-19 and blood group in aortic valve replacement

The COVID-19 pandemic has been found to cause disproportionate harm in patients with cardiovascular disease, especially among the elderly population, among other risk factors. However, a new study published on the preprint server medRxiv* in June 2020 is the first to report its clinical features in patients with aortic stenosis who have had a transcatheter aortic valve replacement (TAVR).

18 Jun 2020

Globally, 350 million could be at risk of severe COVID-19 and hospitalization

Now, a new study shows that one in five individuals is at risk of getting a severe case of COVID-19 due to the presence of underlying disease. The study appeared in the latest issue of The Lancet Global Health this week.

17 Jun 2020

Severity of COVID-19 linked to heparanase activity and heparan sulfate levels

Researchers at Radboud University Medical Center in the Netherlands reported an increase of heparanase activity and heparan sulfate levels in the plasma of patients with coronavirus disease (COVID-19), which was also associated with the severity of the condition – suggesting, in turn, potential treatment utility of low molecular weight heparins. The paper is currently available on the medRxiv* preprint server.

16 Jun 2020

Cell signaling pathway could treat chronic kidney disease and other medical conditions

Scientists have discovered an important cell signaling pathway in the kidney which if stopped, could hold the key to treating chronic kidney disease as well as other deadly conditions, including heart attack and stroke.

16 Jun 2020

Co-existing non-communicable diseases linked to higher risk of illness and death from COVID-19

The interaction of COVID-19 with co-existing non-communicable diseases (NCDs) is a perfect storm, particularly for communities of poverty, according to a new opinion piece published by Columbia Mailman School of Public Health researchers in the journal British Medical Journal.

11 Jun 2020

Seroprevalence of IgM and IgG against SARS-CoV-2 in China

A new study published in the journal Nature Medicine in June 2020 reports the seroprevalence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) across China. This may help to understand the actual prevalence of the virus in the current pandemic.

10 Jun 2020

Cys-C protein can predict risk of cardiovascular and renal diseases

The glomerular filtration rate (GFR) is normally specified as a measure of kidney function. The GFR is the volume of blood that the kidneys filter per minute (the unit of measurement, in relation to a standardized body surface area, is therefore ml/min/1.73 m2).

10 Jun 2020

Identifying key predictors of mortality in young dialysis patients

The percentage of children and young people who have severe kidney disease and require renal replacement therapy (RRT) is relatively low at approximately 2% .

9 Jun 2020

Empagliflozin reduces CKD progression in type 2 diabetics with cardiovascular disease

Empagliflozin (EMPA), a selective inhibitor of sodium/glucose cotransporter 2 (SGLT2 inhibitors, "gliflozines"), reduces CKD progression in type 2 diabetics (T2D) with cardiovascular disease, presumably by lowering intraglomerular pressure.

9 Jun 2020

Metabolic diseases alter ACE2 expression and increase COVID-19 severity

A new study published on the preprint server medRxiv in June 2020 reports that one mechanism for this variable severity is the differential expression of the ACE2 receptor in various metabolic conditions, thereby facilitating viral entry into the host cells.

9 Jun 2020

Indirect viral infection of the kidneys by SARS-CoV-2-induced inflammatory reaction

SARS-CoV-2-associated acute kidney injury is not uncommon. Many hospitalized COVID-19 patients - as many as 80% of critically ill COVID-19 patients, according to a current study - develop acute kidney injury, but without requiring dialysis in most cases. Proteinuria and hematuria are present in about half the cases.

8 Jun 2020

Kidney Disease News and Research

Promising treatment does not guard against complication in type 1 diabetes

Tiny protein in mitochondria has a big impact on health and longevity, study shows

ACE inhibition in kidney could influence pathogenesis of SARS-CoV-2

Common cancer treatments do not worsen COVID-19 infection, study finds

Striking differences found between NHS trusts in COVID-19 ICU deaths

Study identifies new gene variants tied to type-2 diabetes

Heart failure poses the greatest risk of death for people with type 2 diabetes

Clinicians can use patient data to predict life expectancy for older adults with diabetes

Discovery of key steps in kidney formation could have implications for treating renal diseases

COVID-19 and blood group in aortic valve replacement

Globally, 350 million could be at risk of severe COVID-19 and hospitalization

Severity of COVID-19 linked to heparanase activity and heparan sulfate levels

Cell signaling pathway could treat chronic kidney disease and other medical conditions

Co-existing non-communicable diseases linked to higher risk of illness and death from COVID-19

Seroprevalence of IgM and IgG against SARS-CoV-2 in China

Cys-C protein can predict risk of cardiovascular and renal diseases

Identifying key predictors of mortality in young dialysis patients

Empagliflozin reduces CKD progression in type 2 diabetics with cardiovascular disease

Metabolic diseases alter ACE2 expression and increase COVID-19 severity

Indirect viral infection of the kidneys by SARS-CoV-2-induced inflammatory reaction

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