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Study may lead to effective antimicrobial treatment strategies for people with uncontrolled diabetes

Case Western Reserve scientists may have uncovered a molecular mechanism that sets into motion dangerous infection in the feet and hands often occurring with uncontrolled diabetes. It appears that high blood sugar unleashes destructive molecules that interfere with the body's natural infection-control defenses.

7 Aug 2015

Coordinated, two-part approach could help reduce hospital-acquired infections

By coordinating with state health departments and communicating with each other about patients with C. difficile and antibiotic-resistant infections, hospitals, long-term acute-care facilities and nursing homes could reduce the number of such hospital-acquired infections (HAIs) by an estimated 619,000 cases in the next five years, a new Centers for Disease Control 9 (CDC)-led report has found.

5 Aug 2015

Combining chemotherapy and birinapant effective against high-grade serous ovarian cancer

High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but why it so frequently comes back after treatment has been a medical mystery.

4 Aug 2015

15th Annual Geriatric Health Care Symposium now open for registration

Registration is now open for the 15th Annual Geriatric Health Care Symposium, "Maximizing Independence for Optimal Aging," presented by the University of Louisville Institute for Sustainable Health & Optimal Aging.

3 Aug 2015

Study evaluates costs and benefits of medical board recertification for improving healthcare quality

Many physicians are pushing back against or debating new requirements for maintaining medical board certifications, which affect more than 250,000 physicians nationwide. Now, a new study by UC San Francisco and Stanford University researchers concludes that the cost of implementing the most recent requirements will be an estimated $5.7 billion over the next 10 years.

31 Jul 2015

Researchers reconstruct ancient virus to improve gene therapy

Researchers at Massachusetts Eye and Ear/Schepens Eye Research Institute have reconstructed an ancient virus that is highly effective at delivering gene therapies to the liver, muscle, and retina. This discovery, published July 30 in Cell Reports, could potentially be used to design gene therapies that are not only safer and more potent than therapies currently available, but may also help a greater number of patients.

31 Jul 2015

Study could pave way for more targeted treatments for individuals with brain disorders

Like Duke Ellington's 1931 jazz standard, the human brain improvises while its rhythm section keeps up a steady beat. But when it comes to taking on intellectually challenging tasks, groups of neurons tune in to one another for a fraction of a second and harmonize, then go back to improvising, according to new research led by UC Berkeley.

29 Jul 2015

Case Western cancer researchers develop algorithm to detect DNA copy-number alterations in tumors

An algorithm dubbed ENVE could be the Google for genetic aberrations — and it comes from Case Western Reserve.

24 Jul 2015

Endocrine Society selects 18 endocrinologists as winners of 2016 Laureate Awards

The Endocrine Society today announced it has chosen 18 accomplished endocrinologists as winners of the organization's prestigious 2016 Laureate Awards.

24 Jul 2015

Less invasive endovascular aortic repair benefits most patients, provides quick recovery

Each year, nearly 40,000 Americans undergo elective surgery to repair an abdominal aortic aneurysm with the goal of preventing a life-threatening rupture of this potentially dangerous cardiovascular condition.

24 Jul 2015

Retail meat harbors disease-causing Klebsiella pneumoniae, shows new study

Chicken, turkey and pork sold in grocery stores harbors disease-causing bacteria known as Klebsiella pneumoniae, according to a new study. The research, which was published online today in the journal Clinical Infectious Diseases, shows that contaminated meat may be an important source of human exposure to Klebsiella.

23 Jul 2015

Researchers report new drug combination that effectively treats HCV patients co-infected with HIV

Roughly 20 to 30 percent of patients with hepatitis C virus (HCV) are also infected with human immunodeficiency virus type 1 (HIV). Both blood-borne viruses share the same modes of transmission, but many HCV medications currently have significant limitations due to adverse interactions with HIV treatments. Researchers at University of California, San Diego School of Medicine report a new combination that effectively treats HCV in patients co-infected with HIV.

22 Jul 2015

Early antiretroviral treatment prevents AIDS- and non-AIDS-related diseases in HIV-infected people

Starting antiretroviral therapy early not only prevents serious AIDS-related diseases, but also prevents the onset of cancer, cardiovascular disease, and other non-AIDS-related diseases in HIV-infected people, according to a new analysis of data from the Strategic Timing of AntiRetroviral Treatment (START) study, the first large-scale randomized clinical trial to establish that earlier antiretroviral treatment benefits all HIV-infected individuals.

22 Jul 2015

Study: 10% of health care providers prescribe antibiotics for patients with cold, bronchitis or other ARI

10 percent of health care providers write an antibiotic prescription for nearly every patient (95 percent or more) who walks in with a cold, bronchitis or other acute respiratory infection (ARI), according to a new Centers for Disease Control and Prevention-supported study published in the Annals of Internal Medicine and led by the Veterans Affairs Salt Lake City Health Care System and the University of Utah.

21 Jul 2015

Transcranial magnetic stimulation holds promise for tinnitus patients

In the largest U.S. clinical trial of its kind funded by the Veterans Affairs Rehabilitation Research and Development Service, researchers at the VA Portland Medical Center and Oregon Health & Science University found that transcranial magnetic stimulation significantly improved tinnitus symptoms for more than half of study participants.

17 Jul 2015

Big data project: CWRU wins federal grant to develop platform for collection, analysis of clinical data

Case Western Reserve University is one of three institutions nationwide to win federal 'big data' grants focused on developing ways to ensure the integrity and comparability of the reams of information the U.S. health care system collects every day. If successful, the work could create enormous new opportunities to glean insights that help physicians cure or even prevent illness and disease.

16 Jul 2015

CU research suggests safe, lower-cost way to treat upper gastrointestinal tract problems in children

Physicians at the University of Colorado School of Medicine on the Anschutz Medical Campus have published research that suggests a safe and lower-cost way to diagnose and treat problems in the upper gastrointestinal tract of children.

16 Jul 2015

Study highlights how KLF15 protein affects availability of nutrients in the body

Case Western Reserve researchers already demonstrated that a single protein plays a pivotal role in the use of nutrients by major organs that allow for the burning of fat during exercise or regulating the heart's contractile and electrical activity. Now they have found a new benefit of Kruppel-like Factor 15 (KLF15) — keeping the body in metabolic balance.

15 Jul 2015

Scientists detail how stereomicroscopy can help in assessing issues within gastrointestinal tract

A technology whose roots date to the 1800s has the potential to offer an extraordinary new advantage to modern-day medicine.

9 Jul 2015

Researchers develop novel technique to generate activated T cells to tackle advanced melanoma

T cells from patients with melanoma can trigger a protective immune response against the disease according to a new study out of University Hospitals Case Medical Center Seidman Cancer Center and Case Western Reserve University School of Medicine.

8 Jul 2015

Veterans Affairs News and Research

Study may lead to effective antimicrobial treatment strategies for people with uncontrolled diabetes

Coordinated, two-part approach could help reduce hospital-acquired infections

Combining chemotherapy and birinapant effective against high-grade serous ovarian cancer

15th Annual Geriatric Health Care Symposium now open for registration

Study evaluates costs and benefits of medical board recertification for improving healthcare quality

Researchers reconstruct ancient virus to improve gene therapy

Study could pave way for more targeted treatments for individuals with brain disorders

Case Western cancer researchers develop algorithm to detect DNA copy-number alterations in tumors

Endocrine Society selects 18 endocrinologists as winners of 2016 Laureate Awards

Less invasive endovascular aortic repair benefits most patients, provides quick recovery

Retail meat harbors disease-causing Klebsiella pneumoniae, shows new study

Researchers report new drug combination that effectively treats HCV patients co-infected with HIV

Early antiretroviral treatment prevents AIDS- and non-AIDS-related diseases in HIV-infected people

Study: 10% of health care providers prescribe antibiotics for patients with cold, bronchitis or other ARI

Transcranial magnetic stimulation holds promise for tinnitus patients

Big data project: CWRU wins federal grant to develop platform for collection, analysis of clinical data

CU research suggests safe, lower-cost way to treat upper gastrointestinal tract problems in children

Study highlights how KLF15 protein affects availability of nutrients in the body

Scientists detail how stereomicroscopy can help in assessing issues within gastrointestinal tract

Researchers develop novel technique to generate activated T cells to tackle advanced melanoma

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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