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Protein complex plays key role in detecting tumor cells, promotes anti-tumor response

A recently discovered protein complex known as STING plays a crucial role in detecting the presence of tumor cells and promoting an aggressive anti-tumor response by the body's innate immune system, according to two separate studies published in the Nov. 20 issue of the journal Immunity.

21 Nov 2014

Researchers identify genetic signatures in melanoma tumors that predict response to immunotherapy

A team led by Ludwig and Memorial Sloan Kettering (MSK) researchers has published a landmark study on the genetic basis of response to a powerful cancer therapy known as immune checkpoint blockade.

21 Nov 2014

More breast cancer patients choosing to undergo mastectomy, finds Vanderbilt study

Far more breast cancer patients are choosing to undergo mastectomy, including removal of both breasts, instead of choosing breast conservation surgery even when they have early stage disease that is confined to one breast, a Vanderbilt study shows. In the past decade, there have also been marked trends toward higher proportions of women opting for breast reconstruction.

19 Nov 2014

Scientists unravel molecular mechanisms that drive ferroptosis signaling

Ferroptosis is a recently recognized form of regulated necrosis. Up until now, this form of cell death has only been thought to be a possible therapeutic approach to treat tumour cells. Yet, ferroptosis also occurs in non-transformed tissues as demonstrated by this study, thus implicating this cell death pathway in the development of a wide range of pathological conditions. More specifically, the deletion of the ferroptosis-regulating enzyme Gpx4 in a pre-clinical model results in high ferroptosis rates in kidney tubular epithelial cells causing acute renal failure.

19 Nov 2014

New nanoparticles can simultaneously perform MRI and fluorescent imaging in living animals

MIT chemists have developed new nanoparticles that can simultaneously perform magnetic resonance imaging (MRI) and fluorescent imaging in living animals. Such particles could help scientists to track specific molecules produced in the body, monitor a tumor's environment, or determine whether drugs have successfully reached their targets.

19 Nov 2014

Gastric cancer patients who receive chemoradiation after surgery have better survival rates

Patients who receive chemotherapy and radiation after surgery for gastric cancer appear to have better survival rates than those who had surgery followed by only chemotherapy, according to results of a look-back study of more than 500 people by Johns Hopkins scientists.

19 Nov 2014

WSU researchers working on new system to reduce negative effects of cancer drugs

Wichita State University researchers are working on a new system that could decrease the negative effects of cancer drugs on patients.

19 Nov 2014

Moffitt announces development of innovative investigational biologic agent for MDS

In a major step to treat patients living with Myelodysplastic Syndromes (MDS), a group of diseases that affect the bone marrow and blood, Moffitt Cancer Center today announced the development of an innovative investigational biologic agent that could improve patient response and outcomes for MDS and other diseases.

18 Nov 2014

3SBio enters into exclusive license agreement with PharmAbcine for Tanibirumab

3SBio Inc., a leading China-based biotechnology company focused on researching, developing, manufacturing and marketing biopharmaceutical products, today announced it has entered into an exclusive license with PharmAbcine, Inc. for the development, manufacturing and marketing of Tanibirumab, an anti-VEGFR2/KDR antibody for cancer in the territory of Greater China (including Mainland China, Taiwan, Hong Kong and Macau) and several emerging countries, including Thailand, Brazil and Russia.

18 Nov 2014

FDA grants Orphan Drug Designation to Juno's JCAR015 leukemia T cell product candidate

Juno Therapeutics, Inc. announced today that the FDA has granted Orphan Drug Designation to its JCAR015 chimeric antigen receptor product candidate. The designation was granted for treatment of acute lymphoblastic leukemia. JCAR015 Phase I trials are currently underway at Juno's collaboration partner, Memorial Sloane Kettering Cancer Center.

18 Nov 2014

Common antimicrobial in household items causes liver fibrosis, cancer in mice

Triclosan is an antimicrobial commonly found in soaps, shampoos, toothpastes and many other household items. Despite its widespread use, researchers at University of California, San Diego School of Medicine report potentially serious consequences of long-term exposure to the chemical.

18 Nov 2014

Study: Chemotherapy following radiation therapy improves survival in adults with low-grade gliomas

A chemotherapy regimen consisting of procarbazine, CCNU, and vincristine (PCV) administered following radiation therapy improved progression-free survival and overall survival in adults with low-grade gliomas, a form of brain cancer, when compared to radiation therapy alone.

17 Nov 2014

UT Southwestern researchers identify new gene mutations involved in certain kidney cancers

Using next generation gene sequencing techniques, cancer researchers at UT Southwestern Medical Center have identified more than 3,000 new mutations involved in certain kidney cancers, findings that help explain the diversity of cancer behaviors.

17 Nov 2014

EKF Diagnostics and Joslin Diabetes Center enter collaborative relationship

EKF, has entered a collaborative relationship with Joslin Diabetes Center in support of the ongoing clinical and commercial translation of TNFR1 & 2 biomarkers.

From EKF Diagnostics 17 Nov 2014

Cholesterol-fighting statins inhibit uterine fibroid tumors that account for 50% of hysterectomies

Researchers at the University of Texas Medical Branch at Galveston, in collaboration with The University of Texas Health Science Center at Houston (UTHealth), Baylor College of Medicine and the Georgia Regents University, report for the first time that the cholesterol-lowering drug simvastatin inhibits the growth of human uterine fibroid tumors.

16 Nov 2014

New technology improves lung cancer detection during radiation therapy

Researchers from Loyola University Chicago Stritch School of Medicine have developed a technology that improves the detection of tumors during radiation therapy for early-stage lung cancer.

14 Nov 2014

UNC researchers develop new approach to block KRAS oncogene

Researchers from the UNC School of Medicine and colleagues at The University of Texas MD Anderson Cancer Center have developed a new approach to block the KRAS oncogene, one of the most frequently mutated genes in human cancer.

14 Nov 2014

New anti-cancer drug may protect normal cells against radiation

Although radiation treatments have become much more refined in recent years, it remains a challenge to both sufficiently dose the tumor while sparing the surrounding tissue.

14 Nov 2014

Study shows how exosomes secreted by tumor cells promote tumor growth

Researchers at the Bellvitge Biomedical Research Institute of Bellvitge, the Catalan Institute of Oncology and the University Hospital of Bellvitge have participated in an international study published in the journal Cancer Cell that describes how exosomes secreted by tumor cells contain protein and microRNA molecules capable of transform neighboring cells into tumoral cells promoting tumor growth.

14 Nov 2014

Study: Hedgehog cell signaling pathway may play role in breast cancer metastasis

Molecules called long non-coding RNAs (lncRNAs) have been implicated in breast cancer but exactly why they cause metastasis and tumor growth has been little understood…until now.

14 Nov 2014

Tumor News and Research

Protein complex plays key role in detecting tumor cells, promotes anti-tumor response

Researchers identify genetic signatures in melanoma tumors that predict response to immunotherapy

More breast cancer patients choosing to undergo mastectomy, finds Vanderbilt study

Scientists unravel molecular mechanisms that drive ferroptosis signaling

New nanoparticles can simultaneously perform MRI and fluorescent imaging in living animals

Gastric cancer patients who receive chemoradiation after surgery have better survival rates

WSU researchers working on new system to reduce negative effects of cancer drugs

Moffitt announces development of innovative investigational biologic agent for MDS

3SBio enters into exclusive license agreement with PharmAbcine for Tanibirumab

FDA grants Orphan Drug Designation to Juno's JCAR015 leukemia T cell product candidate

Common antimicrobial in household items causes liver fibrosis, cancer in mice

Study: Chemotherapy following radiation therapy improves survival in adults with low-grade gliomas

UT Southwestern researchers identify new gene mutations involved in certain kidney cancers

EKF Diagnostics and Joslin Diabetes Center enter collaborative relationship

Cholesterol-fighting statins inhibit uterine fibroid tumors that account for 50% of hysterectomies

New technology improves lung cancer detection during radiation therapy

UNC researchers develop new approach to block KRAS oncogene

New anti-cancer drug may protect normal cells against radiation

Study shows how exosomes secreted by tumor cells promote tumor growth

Study: Hedgehog cell signaling pathway may play role in breast cancer metastasis

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