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Bevacizumab–erlotinib combined efficacy may depend on VEGF level

Bevacizumab may enhance the antitumour activity of erlotinib by increasing the intratumoural concentration of erlotinib in some non-small-cell lung cancers expressing high levels of vascular endothelial growth factor, Japanese researchers report.

13 Nov 2014

Unique immunochemotherapy approach to treating pancreatic cancer

VCU Massey Cancer Center and VCU Institute of Molecular Medicine researchers discovered a unique approach to treating pancreatic cancer that may be potentially safe and effective. The treatment method involves immunochemotherapy - a combination of chemotherapy and immunotherapy, which uses the patient's own immune system to help fight against disease.

13 Nov 2014

Study identifies genetic alterations that contribute to growth and recurrence of Ewing sarcoma

An international collaboration has identified frequent mutations in two genes that often occur together in Ewing sarcoma (EWS) and that define a subtype of the cancer associated with reduced survival.

13 Nov 2014

K2M receives FDA clearance to market CAPRI Corpectomy Cage System

K2M Group Holdings, Inc., a global medical device company focused on designing, developing and commercializing innovative and proprietary complex spine technologies, techniques and minimally invasive procedures, today announced it has received 510(k) clearance from the U.S. Food and Drug Administration to market the CAPRI Corpectomy Cage System, an expandable vertebral body replacement device that provides structural stability following a corpectomy or vertebrectomy.

13 Nov 2014

Pretreatment ILD is a risk factor for developing radiation pneumonitis in stage I NSCLC patients

Pretreatment interstitial lung disease (ILD) is a significant risk factor for developing symptomatic and severe radiation pneumonitis in stage I non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT) alone.

12 Nov 2014

RPCI researchers identify two novel candidate prognostic markers for ovarian cancer

Cancer researchers at Roswell Park Cancer Institute have identified two independent classes of novel candidate prognostic markers for ovarian cancer, advancing efforts to develop targeted therapies for the disease. The findings resulted from two separate studies published in the peer-reviewed journal PLoS ONE and based on data from The Cancer Genome Atlas (TCGA), the world's largest public database on gene expression in different tumor types.

12 Nov 2014

Mayo Clinic study finds that chromosomal rearrangements can help trace lineage of lung cancer

A diagnostic test based on chromosomal rearrangements can trace the lineage of lung cancer to determine whether two separate lung cancers in the same patient are independent tumors or a tumor that has spread to another region of the lung, a Mayo Clinic study has found. For patients with multiple tumors, that distinction could mean the difference between early stage cancer that may be cured by surgery and incurable late-stage disease.

12 Nov 2014

Study reports anti-cancer activity in mice treated with experimental drug TAK-733

A University of Colorado Cancer Center study published online this week in the journal Molecular Cancer Therapeutics reports anti-cancer activity in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733, a small molecule inhibitor of MEK1/2.

12 Nov 2014

Research finding could lead to new therapies for preventing growth of plexiform neurofibromas

UT Southwestern Medical Center researchers have determined the specific type of cell that gives rise to large, disfiguring tumors called plexiform neurofibromas, a finding that could lead to new therapies for preventing growth of these tumors.

11 Nov 2014

Breakthrough study shows novel molecular imaging drug to detect early prostate cancer

A novel study demonstrates the potential of a novel molecular imaging drug to detect and visualize early prostate cancer in soft tissue, lymph nodes and bone. The research, published in the November issue of the Journal of Nuclear Medicine, compares the biodistribution and tumor uptake kinetics of two Tc-99m labeled ligands, MIP-1404 and MIP-1405, used with SPECT and planar imaging.

11 Nov 2014

High-absorption BCM-95 Curcumin can reduce spread of cancer cells

A recently published cellular study on colorectal cancer showed that high-absorption BCM-95 Curcumin is able to reduce the spread of cancer cells and potentially increase the effectiveness of chemotherapy in the treatment of advanced colon cancer.

11 Nov 2014

ViewRay's MRIdian system gets CE Mark approval

ViewRay, a privately held medical device company, announced today that its MRIdian (me-rid-i-an) system, the world's first and only MRI-guided radiation therapy system, has received CE Mark (Conformite Europeenne) approval.

11 Nov 2014

Researchers refine diagnostic tools to predict treatment outcomes for children with neuroblastoma

Oncology researchers studying gene mutations in the childhood cancer neuroblastoma are refining their diagnostic tools to predict which patients are more likely to respond to drugs called ALK inhibitors that target such mutations. Removing some of the guesswork in diagnosis and treatment, the researchers say, may lead to more successful outcomes for children with this often-deadly cancer.

11 Nov 2014

Researchers find way to defeat elusive target proteins in cancer cells

Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center have found a way to defeat one of the most tantalizing yet elusive target proteins in cancer cells - employing a strategy that turns the protein's own molecular machinations against it.

9 Nov 2014

New vaccination approach can reduce tumor burden, suppress formation of lung metastases

In a new study published in the scientific journal Oncotarget researchers from Uppsala University show that a therapeutic vaccine directed against tumor vessels can reduce tumor burden and suppress formation of spontaneous lung metastases in a mouse model for metastatic breast cancer.

9 Nov 2014

UCSD researchers describe surprising role of protein in embryonic development

Hematopoietic stem cells (HSCs) give rise to all blood and immune cells throughout the life of vertebrate organisms, from zebrafish to humans. But details of their genesis remain elusive, hindering efforts to develop induced pluripotent stem cell (iPSC) replacements that might address a host of blood disorders.

7 Nov 2014

Seattle Children's starts patient enrollment for immunotherapy clinical trial for neuroblastoma

Seattle Children's today announced the opening of patient enrollment for its new cellular immunotherapy clinical research trial designed to induce remission in children suffering from neuroblastoma, one of the deadliest forms of childhood cancer.

7 Nov 2014

Olaparib shows promise for advanced cancers associated with BRCA1 and BRCA2 mutations

Olaparib, an experimental twice-daily oral cancer drug, produces an overall tumor response rate of 26 percent in several advanced cancers associated with BRCA1 and BRCA2 mutations, according to new research co-led by the Abramson Cancer Center of the University of Pennsylvania.

7 Nov 2014

MMRF initiative aims to speed up evaluation of new investigational drugs for multiple myeloma

The Multiple Myeloma Research Foundation today announced an initiative designed to accelerate the evaluation of new investigational therapies for multiple myeloma (MM).

6 Nov 2014

OGT workshop to focus on using latest genomic technologies for accelerating cancer research

Oxford Gene Technology, The Molecular Genetics Company, will present a workshop titled ‘An Integrated Genomic Approach to Tumor Profiling’ at the Association for Molecular Pathology annual meeting on the 12-15th November at National Harbor, MD.

From Oxford Gene Technology 6 Nov 2014

Tumor News and Research

Bevacizumab–erlotinib combined efficacy may depend on VEGF level

Unique immunochemotherapy approach to treating pancreatic cancer

Study identifies genetic alterations that contribute to growth and recurrence of Ewing sarcoma

K2M receives FDA clearance to market CAPRI Corpectomy Cage System

Pretreatment ILD is a risk factor for developing radiation pneumonitis in stage I NSCLC patients

RPCI researchers identify two novel candidate prognostic markers for ovarian cancer

Mayo Clinic study finds that chromosomal rearrangements can help trace lineage of lung cancer

Study reports anti-cancer activity in mice treated with experimental drug TAK-733

Research finding could lead to new therapies for preventing growth of plexiform neurofibromas

Breakthrough study shows novel molecular imaging drug to detect early prostate cancer

High-absorption BCM-95 Curcumin can reduce spread of cancer cells

ViewRay's MRIdian system gets CE Mark approval

Researchers refine diagnostic tools to predict treatment outcomes for children with neuroblastoma

Researchers find way to defeat elusive target proteins in cancer cells

New vaccination approach can reduce tumor burden, suppress formation of lung metastases

UCSD researchers describe surprising role of protein in embryonic development

Seattle Children's starts patient enrollment for immunotherapy clinical trial for neuroblastoma

Olaparib shows promise for advanced cancers associated with BRCA1 and BRCA2 mutations

MMRF initiative aims to speed up evaluation of new investigational drugs for multiple myeloma

OGT workshop to focus on using latest genomic technologies for accelerating cancer research

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How the Arts Reshape Brain Function: Susan Magsamen on the Future of Neuroaesthetics

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