Genome News and Research

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Never smokers' lung adenocarcinomas show greater genome instability

Lung adenocarcinomas in people who have never smoked show greater genome instability than those in smokers, supporting the theory that lung cancer in never smokers arises through different pathways, according to research presented at the 14th World Conference on Lung Cancer in Amsterdam, hosted by the International Association for the Study of Lung Cancer.

5 Jul 2011

Researchers use clever technique to look at in vivo virus-bacterium interactions

Viruses are the most abundant parasites on Earth. Well known viruses, such as the flu virus, attack human hosts, while viruses such as the tobacco mosaic virus infect plant hosts.

2 Jul 2011

Scientists use statistical approach to assess order of genetic abnormalities in cancers

Zeroing in on the early cell mutations that enable a cancer to grow is one of the best ways to find a personalized therapy to stop it. Scientists were able to use a statistical approach for the first time to map out the order in which these abnormalities form to analyze the pattern of DNA changes in advanced skin and ovarian tumors.

2 Jul 2011

STSI receives NIH grant to conduct heart-based research

Researchers looking to find a root cause for heart attacks and coronary artery disease will soon begin using a novel investigative approach that borders on science fiction as they work toward the holy grail of American medicine: preventing the nation's No. 1 killer.

2 Jul 2011

GWAS identifies 15 gene variants responsible for diversity of white blood cell counts

A trio of large-scale genome-wide association studies, or GWAS, have identified more than 15 gene variants responsible for the diversity of white blood cell counts among whites, African-Americans, and Japanese.

1 Jul 2011

Autism Speaks Weatherstone fellows publish new mouse model findings in Cell journal

Autism Speaks Weatherstone Pre-Doctoral Fellows M. Ali Bangash, a 2009 fellow, and Mehreen Kouser, a 2010 fellow, recently published new findings in the journal Cell that shed light on the biology of autism.

1 Jul 2011

Two defective genes may cause telomere elongations in cancer cells: Study

Scientists at Johns Hopkins have provided more clues to one of the least understood phenomena in some cancers: why the "ends caps" of cellular DNA, called telomeres, lengthen instead of shorten.

1 Jul 2011

New analytical approach can organize large amounts of varied cancer genetic data

The technology that allows scientists to profile the entire genome of individual tumors offers new hope for discovering ways to select the best treatment for each patient's particular type of cancer. However, these profiles produce huge amounts of data, and the volume alone creates unique analytical problems.

1 Jul 2011

Ovarian cancer molecular updates

In a new study a genetic mutation was found in the most common form of ovarian cancer. This according to the US scientists could pave the way for a more effective treatment of the disease. The detailed genetic map already helped scientists identify existing drugs with the potential for treating the mutations found in ovarian cancer tumors and also identified mutations that could respond to new drugs.

1 Jul 2011

Researchers identify altered expression of endogenous retroviruses in BSE-infected macaques

Prion diseases such as Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy (BSE) in cattle are transmissible neurodegenerative diseases linked to the aggregation of the prion protein in the central nervous system.

1 Jul 2011

Genetic variation associated with increased risk of sudden cardiac arrest

A study by a global consortium of physician-scientists has identified a genetic variation that may predispose people to double the risk of having a sudden cardiac arrest, a disorder that gives little warning and is fatal in about 95 percent of cases.

1 Jul 2011

Sensitivity of bladder cancer cells linked to chemotherapy and expression of miR-34a gene

Researchers at the UC Davis Cancer Center have discovered a way of sensitizing muscle-invasive bladder cancer cells so that they succumb to the toxic effects of chemotherapy. The finding adds to mounting evidence that tiny strands of RNA - called microRNA - play key roles in some of the deadliest types of cancer.

30 Jun 2011

TCGA examines ovarian serous adenocarcinoma tumors from 500 patients

An analysis of genomic changes in ovarian cancer has provided the most comprehensive and integrated view of cancer genes for any cancer type to date. Ovarian serous adenocarcinoma tumors from 500 patients were examined by The Cancer Genome Atlas (TCGA) Research Network and analyses are reported in the June 30, 2011, issue of Nature.

30 Jun 2011

Genes in Tasmanian Devil give new hope to children with cancer

Cancer researchers have generated a genetic blueprint of the Tasmanian Devil genome, revealing cancer-associated genes that may answer important questions about adult and childhood cancer.

30 Jun 2011

Pregenen, Cellectis partner to develop meganucleases

Cellectis, the French genome engineering specialist, announced today the signing of a collaboration agreement with Pregenen, an American biotechnology start-up company dedicated to the creation of innovative tools for genome engineering.

30 Jun 2011

Drug-resistant scarlet fever outbreak has infected nearly 550 people in Hong Kong

An outbreak of drug-resistant and particularly virulent strains of scarlet fever has infected nearly 550 people and killed two children in Hong Kong so far this year, about double the Chinese city's average annual total, the Associated Press reports.

29 Jun 2011

454 Life Sciences launches new GS FLX+ System for high-throughput sequencing

454 Life Sciences, a Roche Company, announced today the launch and immediate availability of the new GS FLX+ System, an instrument capable of generating extra-long sequencing reads up to 1,000 by in length.

28 Jun 2011

Data from microarrays co-developed by OGT to be presented at ECC 2011

Oxford Gene Technology (OGT), provider of innovative clinical genetics and diagnostic solutions to advance molecular medicine, has announced details of its upcoming workshop at the European Cytogenetics Conference 2011, held in Porto, Portugal (2–5 July).

From Oxford Gene Technology 28 Jun 2011

Biolauncher, Isogenica and Cresset enter joint venture to develop drug discovery platform

Isogenica Ltd today announced a collaborative joint venture with Biolauncher Ltd and Cresset Biomolecular Discovery Ltd to develop an innovative end-to-end therapeutic discovery platform.

28 Jun 2011

Scientists discover origin of Barrett's esophagus

Dr Frank McKeon, Senior Group Leader of the Stem Cell and Developmental Biology at A*STAR's Genome Institute of Singapore, and Principal Investigator Dr Wa Xian at A*STAR's Institute of Medical Biology, together with their counterparts from the Harvard Medical School, the Brigham and Women's Hospital in Boston, and the National University of Singapore, have made the striking finding that Barrett's esophagus work, published online in the journal Cell on 24 June 2011, is essential to developing therapeutics for esophageal cancer.

28 Jun 2011

Genome News and Research

Never smokers' lung adenocarcinomas show greater genome instability

Researchers use clever technique to look at in vivo virus-bacterium interactions

Scientists use statistical approach to assess order of genetic abnormalities in cancers

STSI receives NIH grant to conduct heart-based research

GWAS identifies 15 gene variants responsible for diversity of white blood cell counts

Autism Speaks Weatherstone fellows publish new mouse model findings in Cell journal

Two defective genes may cause telomere elongations in cancer cells: Study

New analytical approach can organize large amounts of varied cancer genetic data

Ovarian cancer molecular updates

Researchers identify altered expression of endogenous retroviruses in BSE-infected macaques

Genetic variation associated with increased risk of sudden cardiac arrest

Sensitivity of bladder cancer cells linked to chemotherapy and expression of miR-34a gene

TCGA examines ovarian serous adenocarcinoma tumors from 500 patients

Genes in Tasmanian Devil give new hope to children with cancer

Pregenen, Cellectis partner to develop meganucleases

Drug-resistant scarlet fever outbreak has infected nearly 550 people in Hong Kong

454 Life Sciences launches new GS FLX+ System for high-throughput sequencing

Data from microarrays co-developed by OGT to be presented at ECC 2011

Biolauncher, Isogenica and Cresset enter joint venture to develop drug discovery platform

Scientists discover origin of Barrett's esophagus

Genetics & Genomics - Second Edition eBook

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

Exploring the G:Box and for high-quality imaging

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