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CASI's ENMD-2076 gets FDA Orphan Drug designation for HCC treatment

CASI Pharmaceuticals, Inc., a clinical-stage pharmaceutical company developing therapeutics for the treatment of cancer and other diseases, announced today that its orally-active, Aurora A/angiogenic kinase inhibitor, ENMD-2076, has received Orphan Drug designation from the U.S. Food and Drug Administration for the treatment of hepatocellular carcinoma (HCC).

7 Jul 2014

$FDA grants Breakthrough Therapy status to Novartis' CTL019 for treatment of relapsed/refractory ALL$

FDA grants Breakthrough Therapy status to Novartis' CTL019 for treatment of relapsed/refractory ALL

Novartis announced today that the United States Food and Drug Administration has granted Breakthrough Therapy status to CTL019, an investigational chimeric antigen receptor (CAR) therapy for the treatment of pediatric and adult patients with relapsed/refractory acute lymphoblastic leukemia (r/r ALL).

7 Jul 2014

Penn’s immunotherapy receives FDA's Breakthrough Therapy designation for ALL treatment

A University of Pennsylvania-developed personalized immunotherapy has been awarded the U.S. Food and Drug Administration's Breakthrough Therapy designation for the treatment of relapsed and refractory adult and pediatric acute lymphoblastic leukemia (ALL).

7 Jul 2014

OHSU professor recognized with AAAS Martin and Rose Wachtel Cancer Research Award

Jeffrey Tyner, Ph.D., assistant professor of Cell, Developmental & Cancer Biology for Oregon Health & Science University (OHSU) and a researcher with OHSU's Knight Cancer Institute, has won a distinguished award from the American Association for the Advancement of Science (AAAS) for the development of a research program that more rapidly identifies the mutations driving a patient's cancer and accelerates development of precision treatments.

4 Jul 2014

Mass spectrometry-based tool successfully used in brain cancer surgery

A tool to help brain surgeons test and more precisely remove cancerous tissue was successfully used during surgery, according to a Purdue University and Brigham and Women's Hospital study.

4 Jul 2014

Discovery points the way to potential new strategies to treat blood disorders

Like a line of falling dominos, a cascade of molecular events in the bone marrow produces high levels of inflammation that disrupt normal blood formation and lead to potentially deadly disorders including leukemia, an Indiana University-led research team has reported.

4 Jul 2014

Loss of p62 protein in cells and tissue surrounding a tumor can influence tumor growth

A team of scientists from Sanford Burnham Medical Research Institute has found that the loss of a protein called p62 in the cells and tissue surrounding a tumor can enhance the growth and progression of tumors.

4 Jul 2014

UCB, Dermira enter into licensing agreement for development, commercialization of Cimzia

UCB, a global biopharmaceutical leader, and Dermira, Inc., a privately held US-based dermatology company, announced today that they have entered into an exclusive licensing agreement for the development and future commercialization of Cimzia (certolizumab pegol) in dermatology.

3 Jul 2014

New hope for women with early-stage breast cancer

Women with early-stage breast cancer may now receive a one-dose radiation treatment at the same time as lumpectomy surgery, eliminating the need to return to the hospital daily for up to six weeks for post surgical radiation treatments.

3 Jul 2014

Cyclin D protein activates key tumor suppressor

Researchers at the University of California, San Diego School of Medicine say a protein essential to regulating cell cycle progression - the process of cell division and replication - activates a key tumor suppressor, rather than inactivating it as previously thought.

3 Jul 2014

Despite management background, VA nominee faces even bigger challenge now

Robert McDonald, the VA secretary nominee, is facing a huge bureaucracy with more than 300,000 employees. Elsewhere, a new poll finds most veterans say getting care at VA hospitals is "very" or "somewhat" difficult.

3 Jul 2014

Lung cancer patients could benefit from new 'QTA' technique

Lung cancer patients could receive more precise treatment, and their progress could be better tracked, using a new high-tech method of non-invasive medical imaging analysis, according to a study published today by the journal PLOS ONE.

3 Jul 2014

First Edition: July 2, 2014

Today's early morning highlights from the major news organizations, including reports about a new audit's findings that the health law's online insurance marketplaces did not adequately screen applicants seeking subsidies.

2 Jul 2014

New collaborative fundraising effort focuses on AYA cancer

Leaders from Case Western Reserve University and University Hospitals this evening announced a new collaborative fundraising effort focused on Adolescent and Young Adult (AYA) cancer.

2 Jul 2014

Mayo Clinic researchers uncover 31 genes key to clear cell renal cell carcinoma

A genomic analysis of clear cell renal cell carcinoma (ccRCC), the most common form of kidney cancer, from 72 patients has uncovered 31 genes that are key to development, growth and spread of the cancer, say researchers from Mayo Clinic in Florida.

2 Jul 2014

Researchers identify new biomarker that predicts effectiveness of glioblastoma treatment

Researchers at the University of California, San Diego School of Medicine have identified a new biomarker that predicts whether glioblastoma - the most common form of primary brain cancer - will respond to chemotherapy. The findings are published in the July print issue of Oncotarget.

2 Jul 2014

Drug everolimus fails to improve overall survival in advanced liver cancer patients

Despite strong preclinical data, the drug everolimus failed to improve overall survival in patients with advanced liver cancer, compared to placebo, according to a study in the July 2 issue of JAMA.

2 Jul 2014

Proton beam therapy improves head and neck cancers free survival compared to IMRT

A new study by radiation oncologists at Mayo Clinic comparing the world's literature on outcomes of proton beam therapy in the treatment of a variety of advanced head and neck cancers of the skull base compared to intensity modulated radiation therapy (IMRT) has found that proton beam therapy significantly improved disease free survival and tumor control when compared to IMRT.

1 Jul 2014

Extract of Chinese herb thunder god vine suppresses pancreatic cancer cell

A diagnosis of pancreatic cancer—the fourth most common cause of cancer death in the U.S.—can be devastating. Due in part to aggressive cell replication and tumor growth, pancreatic cancer progresses quickly and has a low five-year survival rate (less than 5 percent).

1 Jul 2014

Prophage autologous cancer vaccine extends survival in patients with newly diagnosed GBM

Agenus Inc., announced final results from a single-arm, multi-institutional, open-label, Phase 2 study showing that patients with newly diagnosed glioblastoma multiforme (GBM) who received Agenus' Prophage autologous cancer vaccine added to the standard of care treatment, lived nearly twice as long as expected.

1 Jul 2014

Tumor News and Research

CASI's ENMD-2076 gets FDA Orphan Drug designation for HCC treatment

FDA grants Breakthrough Therapy status to Novartis' CTL019 for treatment of relapsed/refractory ALL

Penn’s immunotherapy receives FDA's Breakthrough Therapy designation for ALL treatment

OHSU professor recognized with AAAS Martin and Rose Wachtel Cancer Research Award

Mass spectrometry-based tool successfully used in brain cancer surgery

Discovery points the way to potential new strategies to treat blood disorders

Loss of p62 protein in cells and tissue surrounding a tumor can influence tumor growth

UCB, Dermira enter into licensing agreement for development, commercialization of Cimzia

New hope for women with early-stage breast cancer

Cyclin D protein activates key tumor suppressor

Despite management background, VA nominee faces even bigger challenge now

Lung cancer patients could benefit from new 'QTA' technique

First Edition: July 2, 2014

New collaborative fundraising effort focuses on AYA cancer

Mayo Clinic researchers uncover 31 genes key to clear cell renal cell carcinoma

Researchers identify new biomarker that predicts effectiveness of glioblastoma treatment

Drug everolimus fails to improve overall survival in advanced liver cancer patients

Proton beam therapy improves head and neck cancers free survival compared to IMRT

Extract of Chinese herb thunder god vine suppresses pancreatic cancer cell

Prophage autologous cancer vaccine extends survival in patients with newly diagnosed GBM

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