Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Sygnature Discovery supports New York Medical College pharmacologist in the fight against Covid-19

Sygnature Discovery, a leading independent integrated drug discovery and pre-clinical services company, is supporting Professor Sachin Gupte, a pharmacologist at the New York Medical College, in his endeavours to find a drug treatment for the lung damage that can result from Covid-19 infection.

From Sygnature Discovery Limited 15 Jun 2020

CELLINK collaborates with Lonza to advance complete 3D cell culture workflows

CELLINK has collaborated with Lonza to offer a comprehensive 3-dimensional (3D) bioprinting solution designed to advance complete 3D cell culture workflows.

From CELLINK 12 Jun 2020

Drug-like molecules offer a promising treatment for COVID-19

A team of researchers at the University of Georgia has successfully demonstrated that a set of drug-like small molecules can block the activity of a key SARS-CoV-2 protein-;providing a promising path for new COVID-19 therapeutics.

12 Jun 2020

Protein design can solve the puzzle of Parkinson's disease

Dopamine is a neurotransmitter involved in everything from higher cognitive functions to motor control, motivation, arousal, reinforcement, and sexual gratification, the receptors it acts on have been a longstanding target for treating disorders like Parkinson's disease, which is caused by the degeneration of dopamine-using neurons that control movement.

11 Jun 2020

Research demonstrates novel pathway regulating the underlying mechanism of NASH

CN Bio, a leading cell culture company that has developed single and multi-organ microphysiological systems that improve the accuracy and efficiency of drug discovery, today announced the publication of co-authored research led by researchers at the University of Cambridge in Nature Metabolism, identifying a novel pathway that regulates the underlying mechanism of Non-Alcoholic Steatohepatitis, potentially a new therapeutic target.

10 Jun 2020

Machine learning helps predict clinical forms of drug-induced cardiotoxicity

We announce the publication of a new research paper titled 'Dual transcriptomic and molecular machine learning predicts all major clinical forms of drug cardiotoxicity' in Frontiers in Pharmacology.

9 Jun 2020

Virginia Tech researcher develops new ‘fat burning’ molecule with potential to treat obesity

Obesity affects more than 40 percent of adults in the United States and 13 percent of the global population.

8 Jun 2020

Using antibodies to detect Alzheimer’s disease

News-Medical speaks to Professor Vendruscolo about his research that uses antibodies to detect Alzheimer's disease, which could help to improve drug discovery.

8 Jun 2020

Discovery of new killing mechanism could help design improved teixobactin-based drugs

Scientists at the University of Liverpool and University of Utrecht have taken another step forward on their quest to develop a viable drug based on teixobactin - a new class of potent natural antibiotic capable of killing superbugs.

5 Jun 2020

Focusing on clinical drug research for dementia

Frontiers in Clinical Drug Research - Dementia is a book series which presents comprehensive reviews about research on Dementia, a term which references the loss of brain function associated with Alzheimer's disease and other related medical conditions.

5 Jun 2020

Biorelate offers free access to AI-based drug discovery tool: Galactic

Biorelate, a UK-based AI start up, is offering all researchers free use of Galactic, its cloud-based web tool, to support biomedical research while lab access is restricted around the world.

From Biorelate Ltd 4 Jun 2020

Hesperos’ immune system-on-a-chip emulates immune reactions for tissue damage and acute inflammation

Hesperos Inc., pioneers of the Human-on-a-Chip in vitro system, today announced the publication of a new peer-reviewed publication that describes how the company’s technology can be used to investigate immune responses following treatment with biological therapeutics for multi-organ systemic diseases, including cancer, infectious diseases and inflammatory disorders.

4 Jun 2020

New test identifies CAD-affected children who may benefit from uridine

Scientists at Sanford Burnham Prebys Medical Discovery Institute and the Centro de Biología Molecular Severo Ochoa in Spain have created a test that determines which children with CAD deficiency-; a rare metabolic disease-; are likely to benefit from receiving uridine, a nutritional supplement that has dramatically improved the lives of other children with the condition.

3 Jun 2020

KinaRx receives SBIR grant to speed up clinical trials for AML and other diseases

Acute myeloid leukemia (AML), an aggressive blood cancer, is one of the most lethal cancers. More than 19,000 new cases are diagnosed a year, and more than 11,000 people a year die from it, according to the American Cancer Society.

3 Jun 2020

Gene discovery in fruit flies could lead to treatments for age-related hearing loss

Scientists at UCL have discovered sets of regulatory genes, which are responsible for maintaining healthy hearing. The finding, made in fruit flies, could potentially lead to treatments for age-related hearing loss (ARHL) in humans.

2 Jun 2020

A new tool to help biomedical scientists better understand COVID-19 virus

Biomedical scientists working with COVID-19 have a new tool to help them better understand the virus and feel confident about the structural models they are using in their research.

2 Jun 2020

AstraZeneca implements Genestack’s flagship Omics Data Manager

Genestack Ltd. today announced that its flagship multi-omics data catalogue, curation and integrative search product, Omics Data Manager (ODM), has been licensed and implemented by AstraZeneca.

30 May 2020

Cancer drug nilotinib found to be safe and well-tolerated in Alzheimer's disease clinical trial

A Georgetown University Medical Center clinical trial investigating the cancer drug nilotinib in people with Alzheimer's disease finds that it is safe and well-tolerated, and researchers say the drug should be tested in a larger study to further determine its safety and efficacy as a potential disease-modifying strategy.

29 May 2020

New project launched to find novel treatments for rare genetic diseases

The University Carlos III Madrid, Almirall, S.A. and the MEDINA Foundation have launched a project to find new treatments for recessive dystrophic epidermolysis bullosa and other genetic diseases caused by nonsense mutations.

28 May 2020

SignalChem Biotech Inc. launches COVID-19 elisa kits for diagnostic research

SignalChem, a global leader in cell signaling and protein engineering, has been conducting research on new coronaviruses since the outbreak of the virus.

From SignalChem Biotech Inc. 28 May 2020