Small Molecules News and Research

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Researchers identify potential way to combat TB

Researchers have identified a potential way to manipulate the immune system to improve its ability to fight off tuberculosis.

24 Oct 2013

Genetic mutation found to restore translational balance in mice

In a biological quirk that promises to provide researchers with a new approach for studying and potentially treating Fragile X syndrome, scientists at the University of Massachusetts Medical School (UMMS) have shown that knocking out a gene important for messenger RNA (mRNA) translation in neurons restores memory deficits and reduces behavioral symptoms in a mouse model of a prevalent human neurological disease.

21 Oct 2013

Researchers identify key therapeutic target for cancers driven by KRAS protein

Patients with cancers driven by the protein KRAS, which are particularly hard to treat, may benefit from small molecules that attach to and disrupt the function of a KRAS-containing protein complex, according to results presented here at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19-23.

20 Oct 2013

Suppression of mitochondria: A dominant feature of diabetic kidney disease

Researchers at the University of California, San Diego School of Medicine have identified 13 metabolites - small molecules produced by cellular metabolism - that are significantly different in patients with diabetes and chronic kidney disease compared to healthy controls.

11 Oct 2013

TSRI scientists identify set of compounds to treat multiple sclerosis in new way

Scientists at The Scripps Research Institute (TSRI) have identified a set of compounds that may be used to treat multiple sclerosis (MS) in a new way. Unlike existing MS therapies that suppress the immune system, the compounds boost a population of progenitor cells that can in turn repair MS-damaged nerve fibers.

10 Oct 2013

Two gene mutations associated with increased risk of developing eating disorders

Eating disorders like anorexia nervosa and bulimia often run in families, but identifying specific genes that increase a person's risk for these complex disorders has proved difficult.

9 Oct 2013

A*STAR, Debiopharm Team Up To Develop Epigenetic Cancer Target

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7 Oct 2013

Experimental Therapeutics, Debiopharm join to develop oral small molecules targeting new class of epigenetic modulators

The Agency for Science, Technology and Research (A*STAR)'s Experimental Therapeutics Centre (ETC), a center of excellence to advance and accelerate drug discovery in Singapore, and Debiopharm Group™ (Debiopharm), the Swiss-based global biopharmaceutical company that focuses on the development of prescription drugs that target unmet medical needs including oncology as well as companion diagnostics, today announced the signature of an exclusive research collaboration to develop oral small molecules targeting new class of epigenetic modulators.

7 Oct 2013

Newly discovered compound could be developed as antifungal drug to treat fungal infections

On a molecular level, you have more in common with shower curtain mold or the mushrooms on your pizza than you might think. Humans and fungi share similar proteins, a biological bond that makes curing fungal infections difficult and expensive.

7 Oct 2013

Researchers create catalyst that alters chemical profiles of numerous types of small molecules

Researchers report that they have created a man-made catalyst that is an "enzyme mimic." Unlike most enzymes, which act on a single target, the new catalyst can alter the chemical profiles of numerous types of small molecules.

7 Oct 2013

Researchers study effective ways to get medicine into the brain for treating neurological diseases

A big challenge in medical science is to get medicine into the brain when treating patients with neurological diseases. The brain will do everything to keep foreign substances out and therefore the brains of neurological patients fight a constant, daily battle to throw out the medicine prescribed to help the patients.

26 Sep 2013

UdeM's IRIC and Bristol-Myers Squibb identify small molecule drug candidate against novel target

Universit- de Montr-al and the Institute for Research in Immunology and Cancer - Commercialization of Research today announced that researchers from UdeM's Institute for Research in Immunology and Cancer and Bristol-Myers Squibb Company have jointly identified a small molecule drug candidate against a novel target.

20 Sep 2013

Mayo Clinic receives grant from NIH to support medical research on metabolomics

Mayo Clinic is one of six new federally-funded Comprehensive Metabolomics (met-ah-bol-OH-mics) Centers to support medical research on metabolomics -- the study, at the cellular level, of how molecules are metabolized in the body.

19 Sep 2013

Genomatix adds Genomatix Pathway System to Illumina's BaseSpace Apps

Genomatix today announced it has added the Genomatix Pathway System (GePS) to BaseSpace Apps, Illumina's dedicated applications store and informatics community dedicated to advancing genomic analysis.

12 Sep 2013

Developing Analytical Techniques for Biotherapeutics

News-Medical talks to Dr. Lewis about the development of analytical equipment for a new era of drug development that goes beyond small molecule synthesis.

From Malvern Panalytical 11 Sep 2013

New advances toward making molecular prosthetics a reality

The vision for a new branch of medicine, inspired by the ancient field that began with peg legs and hand hooks, commanded the spotlight in a major address by its pioneer here today at the 246th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.

11 Sep 2013

Biogen Idec, Amicus Launch Parkinson's Collaboration

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10 Sep 2013

Chemists Find New Way To Put The Brakes On Cancer

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10 Sep 2013

Thrombogenics, Bicycle Collaborate On Drugs Targeting Eye Diseases

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5 Sep 2013

Researchers explore seas and oceans to discover novel antibiotics and other medical compounds

The life that inhabits the world's oceans has almost infinite variety. It remains an untapped source of diversity. "The oceans can be deep or shallow, they can be more or less tidal, and they can include unique environments such as volcanic vents," says Brian McNeil ofStrathclyde University in Scotland, UK.

5 Sep 2013

Small Molecules News and Research

Researchers identify potential way to combat TB

Genetic mutation found to restore translational balance in mice

Researchers identify key therapeutic target for cancers driven by KRAS protein

Suppression of mitochondria: A dominant feature of diabetic kidney disease

TSRI scientists identify set of compounds to treat multiple sclerosis in new way

Two gene mutations associated with increased risk of developing eating disorders

A*STAR, Debiopharm Team Up To Develop Epigenetic Cancer Target

Experimental Therapeutics, Debiopharm join to develop oral small molecules targeting new class of epigenetic modulators

Newly discovered compound could be developed as antifungal drug to treat fungal infections

Researchers create catalyst that alters chemical profiles of numerous types of small molecules

Researchers study effective ways to get medicine into the brain for treating neurological diseases

UdeM's IRIC and Bristol-Myers Squibb identify small molecule drug candidate against novel target

Mayo Clinic receives grant from NIH to support medical research on metabolomics

Genomatix adds Genomatix Pathway System to Illumina's BaseSpace Apps

Developing Analytical Techniques for Biotherapeutics

New advances toward making molecular prosthetics a reality

Biogen Idec, Amicus Launch Parkinson's Collaboration

Chemists Find New Way To Put The Brakes On Cancer

Thrombogenics, Bicycle Collaborate On Drugs Targeting Eye Diseases

Researchers explore seas and oceans to discover novel antibiotics and other medical compounds

Shaping the Future of Neuroscience: A Conversation with Atlas Antibodies on the MolBoolean™ and the Impact of SfN 2024

How the Arts Reshape Brain Function: Susan Magsamen on the Future of Neuroaesthetics

Inside the Alzheimer's Association: Dr. Heather Snyder on Driving Research and Collaboration

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