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Study: Chromosomal microarray analysis detects genetic changes related to ASDs better than standard tests

A large study from Children's Hospital Boston and the Boston-based Autism Consortium finds that a genetic test that samples the entire genome, known as chromosomal microarray analysis, has about three times the detection rate for genetic changes related to autism spectrum disorders (ASDs) than standard tests. Publishing in the April issue of Pediatrics (and online March 15), the authors urge that CMA become part of the first-line genetic work-up for ASDs.

15 Mar 2010

UC Irvine researchers play leading role in genome sequencing of Hydra

UC Irvine researchers have played a leading role in the genome sequencing of Hydra, a freshwater polyp that has been a staple of biological research for 300 years.

15 Mar 2010

UVA, Merck collaborate to discover novel drugs for women's reproductive health

The University of Virginia in Charlottesville today announced that it has entered into a research collaboration with Merck (known as MSD outside the United States and Canada) to discover novel drugs for women's reproductive health.

12 Mar 2010

Childhood obesity: Genetic variation could be a factor

Increasing childhood obesity has worried governments and public health advisers in many countries. But a study of 300 children with severe obesity by the University of Cambridge and the Wellcome Trust Sanger Institute, suggest the problem may be more complicated than simply bad diet, overeating, or lack of exercise.

12 Mar 2010

Discovery of novel cellular mechanism may help develop new treatments for cancer

A research team led by the University of Colorado at Boulder has discovered a previously unknown cellular "switch" that may provide researchers with a new means of triggering programmed cell death, findings with implications for treating cancer.

12 Mar 2010

Illumina sequences DNA of American actress Glenn Close

Illumina, Inc. today announced that it has sequenced the DNA of American actress Glenn Close, the first publicly named female to have her DNA sequenced to full coverage.

From Illumina, Inc. 11 Mar 2010

Whole genome sequencing of entire family beneficial

The Institute for Systems Biology (ISB) has analyzed the first whole genome sequences of a human family of four. The findings of a project funded through a partnership between ISB and the University of Luxembourg was published online today by Science on its Science Express website. It demonstrates the benefit of sequencing entire families, including lowering error rates, identifying rare genetic variants and identifying disease-linked genes.

11 Mar 2010

Investigators develop new mathematical approach to analyze molecular data

Investigators have developed a new mathematical approach to analyze molecular data derived from complex mixtures of immune cells. This approach, when combined with well-established techniques, readily identifies changes in small samples of human whole blood, and has the potential to distinguish between health and disease states.

11 Mar 2010

Genomatix systems utilized to analyze cis and epigenetic elements that control reproductive events

The C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, at the Wayne State University School of Medicine, in collaboration with the Center for Molecular Medicine and Genetics, the Karmanos Cancer Institute and the Institute for Environmental Health Sciences, installed a Genomatix Mining Station and a Genomatix Genome Analyzer last year at their labs in Detroit, MI in order to support the analysis of Next Generation Sequencing (NGS) data.

11 Mar 2010

BioInvent International, HGS announce collaboration to develop therapeutic monoclonal antibodies

BioInvent International AB and Human Genome Sciences, Inc. today announced that they have entered into a collaboration to discover, develop and commercialize therapeutic monoclonal antibodies which specifically target antigens discovered by HGS.

11 Mar 2010

ISB uses Complete Genomics’ service to sequence genomes of four family members suffer from Miller syndrome

Complete Genomics Inc., a third-generation human genome sequencing company, today announced that the Institute for Systems Biology employed Complete Genomics’ human genome sequencing service to sequence a family quartet to determine the depth of genetic information possible in analyzing a full family’s sequence, and to verify the gene responsible for Miller syndrome, a rare craniofacial disorder.

11 Mar 2010

HGS, BioInvent International AB to discover, develop and commercialize therapeutic monoclonal antibodies

Human Genome Sciences, Inc. and BioInvent International AB today announced that they have entered into a collaboration to discover, develop and commercialize therapeutic monoclonal antibodies that specifically target antigens discovered by HGS.

11 Mar 2010

Scientists identify specific causative genetic mutation associated with CMT

Scientists using advanced genomic analysis technologies from Life Technologies Corporation have sequenced an individual’s genome and identified the specific causative mutation associated with Charcot-Marie-Tooth Disease (CMT), one of the most common inherited neurological disorders currently affecting 1 in 2,500 individuals in the United States.

11 Mar 2010

TGen deploys Isilon IQ to power multiple genome sequencing devices to discover new treatments for diseases

Isilon® Systems today announced that The Translational Genomics Research Institute has deployed Isilon scale-out NAS as the primary storage solution powering its next-generation biomedical research. By using Isilon IQ to power multiple genome sequencing devices, TGen has unified its mission-critical operations onto a single, high-performance, highly scalable shared pool of storage, increasing workflow productivity and reducing costs to accelerate the discovery of new treatments for life-threatening diseases.

10 Mar 2010

Study validates Chronix Biomedical’s serum DNA blood tests for early, accurate detection of breast cancer

Chronix Biomedical today announced publication of a study that supports the utility of its serum DNA blood tests for the early and accurate detection of breast cancer. The Chronix tests detect the circulating DNA that is released into the blood stream by damaged and dying cells. A growing body of publications from Chronix and other researchers shows that this circulating DNA can be identified and analyzed to provide a diagnostic window into ongoing changes in the genome associated with specific diseases—changes that can be used to identify disease processes at an early stage and to track responses to treatment.

9 Mar 2010

USF study: HHV-6 causes permanent infection by inserting its DNA into human chromosomes

Human herpesvirus 6 (HHV-6) infects nearly 100 percent of humans in early childhood, and the infection then lasts for the rest of a person's life. Now, a team led by Peter Medveczky, MD, a professor in the Department of Molecular Medicine at the University of South Florida, has discovered that in some individuals, HHV-6 causes such a permanent infection by inserting or "integrating" its DNA into human chromosomes.

9 Mar 2010

IEEE, AMA to host conference: Overcoming challenges in individualized healthcare, technological innovations

IEEE, the world's largest technical professional association, and the American Medical Association, are joining together to host the First Conference on Medical Technology and Individualized Healthcare.

9 Mar 2010

RDS launches international outreach program on cognitive impairment in Down syndrome patients

Research Down Syndrome has launched an international outreach program to focus awareness and support for the rapidly advancing area of biomedical research leading to safe and effective approved medical therapies to treat cognitive impairment in individuals of all ages with Down syndrome -- improving memory, learning and communication.

9 Mar 2010

Fluidigm's Access Array System: New 5kb and 10kb long-range PCR protocols introduced

Fluidigm Corporation today announced the release of 5kb and 10kb long-range PCR protocols for its Access Array™ System. Researchers interested in targeted re-sequencing projects for large cohort studies can use these new protocols and the Fluidigm Access Array System to amplify up to 48 samples per array. Long-range PCR enables new applications on the Access Array System by allowing researchers to enrich significantly more sequence per sample.

8 Mar 2010

Scientists identify EoE-associated region in human chromosome

Scientists have identified a region of a human chromosome that is associated with eosinophilic esophagitis (EoE), a recently recognized allergic disease. People with EoE frequently have difficulty eating or may be allergic to one or more foods. This study further suggests that a suspected so-called master allergy gene may play a role in the development of this rare but debilitating disorder.

8 Mar 2010

Genome News and Research

Study: Chromosomal microarray analysis detects genetic changes related to ASDs better than standard tests

UC Irvine researchers play leading role in genome sequencing of Hydra

UVA, Merck collaborate to discover novel drugs for women's reproductive health

Childhood obesity: Genetic variation could be a factor

Discovery of novel cellular mechanism may help develop new treatments for cancer

Illumina sequences DNA of American actress Glenn Close

Whole genome sequencing of entire family beneficial

Investigators develop new mathematical approach to analyze molecular data

Genomatix systems utilized to analyze cis and epigenetic elements that control reproductive events

BioInvent International, HGS announce collaboration to develop therapeutic monoclonal antibodies

ISB uses Complete Genomics’ service to sequence genomes of four family members suffer from Miller syndrome

HGS, BioInvent International AB to discover, develop and commercialize therapeutic monoclonal antibodies

Scientists identify specific causative genetic mutation associated with CMT

TGen deploys Isilon IQ to power multiple genome sequencing devices to discover new treatments for diseases

Study validates Chronix Biomedical’s serum DNA blood tests for early, accurate detection of breast cancer

USF study: HHV-6 causes permanent infection by inserting its DNA into human chromosomes

IEEE, AMA to host conference: Overcoming challenges in individualized healthcare, technological innovations

RDS launches international outreach program on cognitive impairment in Down syndrome patients

Fluidigm's Access Array System: New 5kb and 10kb long-range PCR protocols introduced

Scientists identify EoE-associated region in human chromosome

eBook: A guide to RNA sequencing eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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