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FDA grants Orphan Drug Designation to Advaxis' ADXS-HPV for HPV-associated head and neck cancer

Advaxis, Inc.,, a leader in developing the next generation of cancer immunotherapies, announced that it has been granted Orphan Drug Designation from the U.S. Food and Drug Administration Office of Orphan Products Development for ADXS-HPV, its lead drug candidate, for the treatment of human papillomavirus-associated head and neck cancer.

6 Nov 2013

Duke Cancer Institute is one among 41 cancer centers in U.S to hold distinction

Established and designated by the National Cancer Institute as one of eight original comprehensive cancer centers in 1973, the Duke Cancer Institute (DCI) is now among just 41 cancer centers in the United States to hold that distinction.

6 Nov 2013

Stanford researchers receive $1.37M grant to study on immune systems of pediatric cancer patients

Kathleen Sakamoto, MD, PhD, and Irving Weissman, MD, of the Stanford University School of Medicine and Lucile Packard Children's Hospital, have received a $1.37 million grant from CureSearch for Children's Cancer to research the effects of an antibody that has been shown to be effective against human cancers in animal models.

5 Nov 2013

Effective strategy for noninvasive detection of cancer

Molecules that bind and illuminate proteins specific to tumor cells are key to detecting cancer as early as possible. The cyclooxygenase-2 enzyme is just such a protein, as the concentration of COX-2 is greater in cancer cells than in adjacent normal tissues.

5 Nov 2013

Gene mutated in rare hereditary disorder also prevents mTORC1 pathway activation

Whitehead Institute scientists report that the gene mutated in the rare hereditary disorder known as Birt-Hogg-Dub- cancer syndrome also prevents activation of mTORC1, a critical nutrient-sensing and growth-regulating cellular pathway.

5 Nov 2013

Researchers identify factor that promotes metastasis of colon tumors

Tumors become highly malignant when they acquire the ability to colonize other tissues and form metastases. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have identified a factor that promotes metastasis of colon tumors - and presents a possible target for therapy.

5 Nov 2013

Computer-aided image analysis provides "second opinion" to identify breast tumor

Researchers at the University of Chicago are developing computer-aided diagnosis (CADx) and quantitative image analysis (QIA) methods for mammograms, ultrasounds and magnetic resonance images (MRIs) to identify specific tumor characteristics, including size, shape and sharpness, said lead researcher Maryellen Giger, A.N. Pritzker Professor of Radiology/Medical Physics and director of the Imaging Research Institute at the University of Chicago.

5 Nov 2013

Viewpoints: Website is like 'a patient bleeding from self-inflicted wounds;' remembering patients who never had care and the need for health law

Obamacare is starting to resemble a patient bleeding from self-inflicted wounds. A month after launch, the online health exchanges where individuals are supposed to shop for insurance remain slow or unusable, except in states that opted to run their own marketplaces and did a more competent job than the administration. As if that weren't trouble enough, critics are justifiably mocking President Obama for his repeated, untrue promise that if people liked their health plans, they could keep them. Oops. Hundreds of thousands of people are getting termination notices for plans that don't meet the strict new requirements of the Affordable Care Act. Presumably, not all those people disliked their plans (11/3).

5 Nov 2013

Biothera announces top-line results from Phase 2b clinical trial in non-small cell lung cancer

Biothera announced today top-line results from its Phase 2b clinical trial in non-small cell lung cancer (NSCLC) that evaluated its immunotherapeutic drug candidate, Imprime PGG®, with cetuximab (Erbitux®), carboplatin and paclitaxel compared with the monoclonal antibody and chemotherapy combination alone.

5 Nov 2013

Neurosurgeons use minimally-invasive technique to remove brain tumor

More than two decades ago, Ryan Vincent had open brain surgery to remove a malignant brain tumor, resulting in a lengthy hospital stay and weeks of recovery at home.

5 Nov 2013

Scientists identify new algorithm to distinguish two subtypes of malignant melanoma

Scientists of the University of Ulm and Columbia University have discovered a diagnostic algorithm to distinguish two subtypes of malignant melanoma. Desmoplastic and spindle cell melanoma may look alike - they often resemble little scars or retractions of the skin - but differ in prognosis and therapeutic options.

4 Nov 2013

Gene sequencing reveals mutations in estrogen receptor

Researchers at the University of Michigan Comprehensive Cancer Center have identified a type of mutation that develops after breast cancer patients take anti-estrogen therapies. The mutations explain one reason why patients often become resistant to this therapy.

4 Nov 2013

LMU researchers identify a factor that promotes metastasis of colon tumors

Tumors become highly malignant when they acquire the ability to colonize other tissues and form metastases. Researchers at Ludwig-Maximilians-Universitaet in Munich have identified a factor that promotes metastasis of colon tumors - and presents a possible target for therapy.

4 Nov 2013

FDG-PET parameter predicts locally advanced lung cancer survival

High post-treatment concentrations of a radioactive imaging marker are predictive of worse overall survival from inoperable, locally advanced non-small-cell lung cancer, prospective study findings suggest.

31 Oct 2013

DNA methylation signature marks recurrence in early stage lung cancer

An international research team has identified a DNA methylation signature that identifies patients with stage I non-small-cell lung cancer who are at high risk for relapse.

31 Oct 2013

ARIAD temporarily suspends commercial distribution of Iclusig drug in US

ARIAD Pharmaceuticals, Inc. today announced that it is temporarily suspending the marketing and commercial distribution of Iclusig® (ponatinib), a treatment for patients with resistant or intolerant chronic myeloid leukemia (CML) and Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL), in the United States, while it continues to negotiate updates to the U.S. prescribing information for Iclusig and implementation of a risk mitigation strategy.

31 Oct 2013

Scientists uncover new mechanism through which gene expression is regulated

A new study by Weill Cornell Medical College scientists reveals a mechanism through which the expression of genes is controlled -- a finding that highlights genetic mutations that can impair the timing of gene expression.

31 Oct 2013

Next-generation sequencing may help discover genetic changes that might lead to cancer

A pilot study led by the Translational Genomics Research Institute and the Virginia G. Piper Cancer Center at Scottsdale Healthcare shows that, even for patients with advanced and rapidly transforming cancer, researchers can find potential therapeutic targets using the latest advances in genomic sequencing.

31 Oct 2013

Researcher receives prestigious NCI grant to investigate unexplored area of cancer research

The National Cancer Institute's (NCI) new Provocative Questions research funding program has awarded a prestigious grant to a researcher at Roswell Park Cancer Institute (RPCI) to investigate a promising but neglected or unexplored area of cancer research.

31 Oct 2013

RI-MUHC researchers identify genetic changes that could pave way for early diagnosis of CRC

Diagnosing colorectal cancer is complex; it relies on significant invasive tests and subjective evaluations. This process may soon become much easier thanks to a medical breakthrough by scientists at the Research Institute of the McGill University Health Centre.

31 Oct 2013

Tumor News and Research

FDA grants Orphan Drug Designation to Advaxis' ADXS-HPV for HPV-associated head and neck cancer

Duke Cancer Institute is one among 41 cancer centers in U.S to hold distinction

Stanford researchers receive $1.37M grant to study on immune systems of pediatric cancer patients

Effective strategy for noninvasive detection of cancer

Gene mutated in rare hereditary disorder also prevents mTORC1 pathway activation

Researchers identify factor that promotes metastasis of colon tumors

Computer-aided image analysis provides "second opinion" to identify breast tumor

Viewpoints: Website is like 'a patient bleeding from self-inflicted wounds;' remembering patients who never had care and the need for health law

Biothera announces top-line results from Phase 2b clinical trial in non-small cell lung cancer

Neurosurgeons use minimally-invasive technique to remove brain tumor

Scientists identify new algorithm to distinguish two subtypes of malignant melanoma

Gene sequencing reveals mutations in estrogen receptor

LMU researchers identify a factor that promotes metastasis of colon tumors

FDG-PET parameter predicts locally advanced lung cancer survival

DNA methylation signature marks recurrence in early stage lung cancer

ARIAD temporarily suspends commercial distribution of Iclusig drug in US

Scientists uncover new mechanism through which gene expression is regulated

Next-generation sequencing may help discover genetic changes that might lead to cancer

Researcher receives prestigious NCI grant to investigate unexplored area of cancer research

RI-MUHC researchers identify genetic changes that could pave way for early diagnosis of CRC

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