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Gene therapy for advanced heart failure shows promising results

Phase I results of the first clinical trial of gene therapy for patients with advanced heart failure show the approach to be promising, with improvements in several measures of the condition's severity.

10 Nov 2008

VIA Pharmaceuticals announces results of phase 2 trials of VIA-2291 in cardiovascular disease

VIA Pharmaceuticals, Inc. has announced the results of two Phase 2 studies of its lead drug, VIA-2291.

10 Nov 2008

Crestor (rosuvastatin calcium) shown to significantly reduce major cardiovascular events

New data from the JUPITER study demonstrated that Crestor (rosuvastatin calcium) 20 mg significantly reduced major cardiovascular (CV) events (defined in this study as the combined risk of myocardial infarction, stroke, arterial revascularization, hospitalization for unstable angina, or death from CV causes) by a dramatic 44% compared to placebo (p<0.001) among men and women with elevated hsCRP but low to normal cholesterol levels.

10 Nov 2008

Researchers discover metabolic deficiency in pancreatic cancer

UC Davis Cancer Center researchers have discovered a metabolic deficiency in pancreatic cancer cells that can be used to slow the progress of the deadliest of all cancers.

7 Nov 2008

Researchers find new path to antibiotics in dirt

A teaspoon of dirt contains an estimated 10,000 species of bacteria, but it's only one percent of these microbial bugs - the ones that can be grown easily in a lab - that have brought us antibiotics, anticancer agents and other useful drugs.

7 Nov 2008

Anti-herpes drug acyclovir inhibits HIV replication, but with a price

The anti-herpes drug acyclovir can also directly slow down HIV infection by targeting the reverse transcriptase (RT) enzyme, researchers report in this week's JBC.

7 Nov 2008

Accelr8 announces study results with BACcel diagnostic system for broad resistance in gram-negative pathogens

Accelr8 Technology Corporation announced study results today that were presented at the joint sessions of the 48 th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC, www.icaac.org) and the Infectious Diseases Society of America (IDSA, www.idsociety.org), October 25-29 in Washington, DC.

7 Nov 2008

Scientists confirm a molecular clipping mechanism behind stem cell development

Stem cells don't just become a part of the liver or the brain in a flash; it takes a complex molecular choreography and requires that specific genes be switched on and off at specific times.

6 Nov 2008

Scientists identify compounds for stem-cell production from adult cells

In the study, the scientists screened known drugs and identified small molecules that could replace conventional reprogramming genes, which can have dangerous side effects.

6 Nov 2008

Gail model no better than coin flip in predicting risk of breast cancer

A statistical model commonly used to predict the risk of breast cancer in women was not accurate when used to evaluate women with atypical hyperplasia, according to a new Mayo Clinic study published in the Oct. 14, 2008, issue of the Journal of Clinical Oncology.

6 Nov 2008

Proteomics provides clues to how tuberculosis thwarts the immune system

A link between the immune system and the self-cleaning system by which biological cells rid themselves of obsolete or toxic parts may one day yield new weapons in the fight against tuberculosis and other deadly infectious diseases.

6 Nov 2008

Wide variability in rheumatoid arthritis drug Methotrexate suggests alternative dosing should be considered

Methotrexate (MTX) is commonly used to treat rheumatoid arthritis (RA) and is suggested as the "anchor" drug in treating the disease.

5 Nov 2008

Lung airway cells activate vitamin D and increase immune response

Vitamin D is essential to good health but needs to be activated to function properly in the human body.

5 Nov 2008

Pycnodysostosis sheds light on enzyme's role in bone metabolism

Pycnodysostosis, a condition from which the painter Henri de Toulouse-Lautrec suffered, is a genetic disease characterized by short stature.

5 Nov 2008

Resveratrol type drug mimics low-cal diet to ward off weight gain

A drug designed to specifically hit a protein linked to the life-extending benefits of a meager diet can essentially trick the body into believing food is scarce even when it isn't, suggests a new report in the November Cell Metabolism.

5 Nov 2008

Apelin hormone shows promise as target for managing insulin resistance and type 2 diabetes

By injecting a hormone produced by fat and other tissues into mice, researchers report in the November Cell Metabolism that they significantly lowered blood sugar levels in normal and obese mice.

5 Nov 2008

New weapon in the fight against obesity and diabetes

A study appearing November 5 in the journal Cell Metabolism demonstrates that a synthetic new chemical entity protects against diet-induced obesity, improves glucose tolerance and insulin sensitivity and enhances exercise endurance by enhancing fat utilization in certain target tissues.

4 Nov 2008

Enzyme News and Research

Gene therapy for advanced heart failure shows promising results

VIA Pharmaceuticals announces results of phase 2 trials of VIA-2291 in cardiovascular disease

Crestor (rosuvastatin calcium) shown to significantly reduce major cardiovascular events

Researchers discover metabolic deficiency in pancreatic cancer

Researchers find new path to antibiotics in dirt

Anti-herpes drug acyclovir inhibits HIV replication, but with a price

Accelr8 announces study results with BACcel diagnostic system for broad resistance in gram-negative pathogens

Scientists confirm a molecular clipping mechanism behind stem cell development

Scientists identify compounds for stem-cell production from adult cells

Gail model no better than coin flip in predicting risk of breast cancer

Proteomics provides clues to how tuberculosis thwarts the immune system

Wide variability in rheumatoid arthritis drug Methotrexate suggests alternative dosing should be considered

Lung airway cells activate vitamin D and increase immune response

Pycnodysostosis sheds light on enzyme's role in bone metabolism

Resveratrol type drug mimics low-cal diet to ward off weight gain

Apelin hormone shows promise as target for managing insulin resistance and type 2 diabetes

New weapon in the fight against obesity and diabetes

Targeting epigenetic changes helps tackle MLL-AF4 leukemias

Parasites that live inside cells use loophole to thwart immune system

No need for RNA

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