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Common food additive alters gut microbiota in mice

A common food additive, recently banned in France but allowed in the U.S. and many other countries, was found to significantly alter gut microbiota in mice, causing inflammation in the colon and changes in protein expression in the liver, according to research led by a University of Massachusetts Amherst food scientist.

25 Jun 2020

Whole genome sequencing can improve diagnosis and treatment of patients with rare diseases

A research programme pioneering the use of whole genome sequencing in the NHS has diagnosed hundreds of patients and discovered new genetic causes of disease.

24 Jun 2020

Male COVID-19 patients produce more SARS-CoV-2 antibodies than women

Health officials in the United Kingdom urge male coronavirus survivors to donate blood, particularly its convalescent plasma component. This comes after a new study has found that men produce more antibodies, which could make their plasma a valuable treatment against the coronavirus disease (COVID-19).

23 Jun 2020

HCV-positive organs can be safely used for transplantation, study shows

Patients who received a transplanted liver infected with hepatitis C and were later treated for the infection performed as well in recovery as transplant patients who received an organ free of infection, according to study from the University of Cincinnati College of Medicine and UC Health recently published in the journal Liver Transplantation.

22 Jun 2020

Tumor cell–based vaccine may prevent relapse of mantle cell lymphoma

A phase I/II clinical trial by researchers at Stanford University suggests that vaccines prepared from a patient's own tumor cells may prevent the incurable blood cancer mantle cell lymphoma (MCL) from returning after treatment.

22 Jun 2020

Scottish biotech Invizius seeks Series A funding for breakthrough in dialysis treatment

Scottish biotech firm Invizius, which has developed a technology aimed at reducing long-term side effects and health complications from dialysis treatment, is seeking Series A funding after undergoing promising safety trials.

22 Jun 2020

C-Path's Transplant Therapeutics Consortium receives positive FDA response for its Letter of Intent

Critical Path Institute announced today that its Transplant Therapeutics Consortium has received a positive response to its Letter of Intent from the U.S. Food and Drug Administration detailing the decision to accept the Composite Biomarker Panel (iBox Scoring System) into the Center for Drug Evaluation and Research (CDER) Biomarker Qualification Program.

17 Jun 2020

New test will help better manage patients with severe combined immunodeficiency

A new test developed at CHU Sainte-Justine in Montreal will enable better management of patients with severe combined immunodeficiency.

17 Jun 2020

Researchers call for caution of using CAR-T immunotherapy against AML

Acute myeloid leukemia is a hematological malignancy which incidence increases with age, that is biologically, phenotypically, and genetically very heterogeneous.

17 Jun 2020

Study investigates effectiveness of liver perfusion to improve the function of donor livers

A major study investigating the effectiveness of liver perfusion as a technique to improve the function of donor livers that would have otherwise been rejected has shown that up to 7 in every 10 could be used after just 4-6 hours of the assessment.

17 Jun 2020

Novel antisense drug shows promise to improve health of people with NAFLD

Using a first-of-its-class drug in a clinical trial, an international research effort headed by a scientist at University of California San Diego School of Medicine reports that inhibition of a key enzyme safely and effectively improved the health of persons with non-alcoholic fatty liver disease, a chronic metabolic disorder that affects hundreds of millions of people worldwide.

16 Jun 2020

UCLA receives nearly $14 million NIH grant to investigate immunotherapy to destroy HIV

UCLA researchers and colleagues have received a $13.65 million grant from the National Institutes of Health to investigate and further develop an immunotherapy known as CAR T, which uses genetically modified stem cells to target and destroy HIV.

16 Jun 2020

Cell signaling pathway could treat chronic kidney disease and other medical conditions

Scientists have discovered an important cell signaling pathway in the kidney which if stopped, could hold the key to treating chronic kidney disease as well as other deadly conditions, including heart attack and stroke.

16 Jun 2020

New model predicts patients’ likelihood of testing positive for COVID-19

Cleveland Clinic researchers have developed the world's first risk prediction model for healthcare providers to forecast an individual patient's likelihood of testing positive for COVID-19 as well as their outcomes from the disease.

16 Jun 2020

A new technology to print 3D tissues directly in the body

In the TV series Westworld, human body parts are built on robotic frames using 3D printers. While still far from this scenario, 3D printers are being increasingly used in medicine.

15 Jun 2020

Millimeter-thick cell-laden hydrogel fiber helps control blood glucose in diabetic mice

Type 1 diabetes mellitus results from an irreversible autoimmune destruction of insulin-producing pancreatic β-cells requiring life-long substitution of insulin.

15 Jun 2020

Specially designed new heart boxes can enable safer heart transplants

A donated heart can now be transported and preserved for longer than what has previously been possible. The new method, which consists of a specially designed heart box, was used for a transplant for the first time as early as the summer of 2017.

15 Jun 2020

Specially designed heart boxes can enable safer heart transplants

15 Jun 2020

Remdesivir prevents replication of SARS-CoV-2 in human intestinal organoids

A new German study published on the preprint server bioRxiv* in June 2020 shows that the drug remdesivir can reduce the replication of SARS-CoV-2 in human intestinal organoids.

14 Jun 2020

Texas Heart Institute and 7 Hills Pharma receive $1.9 million to improve stem cell transplants

The Texas Heart Institute and 7 Hills Pharma received a $1.9 million, Phase II STTR (R42) grant from the National Heart Lung Blood Institute to advance further their lead product 7HP349, a novel integrin activator, to define the optimal dosing schedule for cord blood transplant along with a focus on development and production of a formulation that meets safety standards for filing an IND application with the FDA.

12 Jun 2020

Transplant News and Research

Common food additive alters gut microbiota in mice

Whole genome sequencing can improve diagnosis and treatment of patients with rare diseases

Male COVID-19 patients produce more SARS-CoV-2 antibodies than women

HCV-positive organs can be safely used for transplantation, study shows

Tumor cell–based vaccine may prevent relapse of mantle cell lymphoma

Scottish biotech Invizius seeks Series A funding for breakthrough in dialysis treatment

C-Path's Transplant Therapeutics Consortium receives positive FDA response for its Letter of Intent

New test will help better manage patients with severe combined immunodeficiency

Researchers call for caution of using CAR-T immunotherapy against AML

Study investigates effectiveness of liver perfusion to improve the function of donor livers

Novel antisense drug shows promise to improve health of people with NAFLD

UCLA receives nearly $14 million NIH grant to investigate immunotherapy to destroy HIV

Cell signaling pathway could treat chronic kidney disease and other medical conditions

New model predicts patients’ likelihood of testing positive for COVID-19

A new technology to print 3D tissues directly in the body

Millimeter-thick cell-laden hydrogel fiber helps control blood glucose in diabetic mice

Specially designed new heart boxes can enable safer heart transplants

Specially designed heart boxes can enable safer heart transplants

Remdesivir prevents replication of SARS-CoV-2 in human intestinal organoids

Texas Heart Institute and 7 Hills Pharma receive $1.9 million to improve stem cell transplants

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

Automating research - solutions and best practices

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