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Novel approach for treating mitochondrial disorders wins Kaye prize

A novel concept for the treatment of mitochondrial disorders using directed enzyme replacement therapy (DERT) has won for a Hebrew University of Jerusalem doctoral candidate one of this year's Kaye Innovation Awards. The awards were presented at this year's 71st meeting of the Hebrew University Board of Governors.

30 Jun 2008

Growth-stimulating molecule called p110beta a promising cancer drug target in prostate tumors

Scientists at Dana-Farber Cancer Institute report they have blocked the development of prostate tumors in cancer-prone mice by knocking out a molecular unit they describe as a "powerhouse" that drives runaway cell growth.

27 Jun 2008

Clinical Data secures European patent for key multi-drug resistance gene

Clinical Data, Inc. has announced that the European Patent Office has granted Patent No. 1232260 to Bernried, Germany-based Epidauros Biotechnologie AG, a wholly-owned subsidiary of Clinical Data, relating to the use of a genetic variant, or biomarker, of the gene MDR1 (also known as ABCB1), which encodes P-glycoprotein (PGP).

26 Jun 2008

Discovery of second genetic risk factor for developing late-onset Alzheimer's disease

Researchers have discovered the second, strong genetic risk factor for developing late-onset Alzheimer's disease, according to a new report in the June 27th issue of the journal Cell, a Cell Press publication.

25 Jun 2008

Study uncovers a mechanism that explains calcium abnormalities in Alzheimer's brain

A new study uncovers a mechanism that directly links mutations that cause early onset Alzheimer's disease (AD) with aberrant calcium signaling. The research, published by Cell Press in the June 26th issue of the journal Neuron, provides exciting molecular insights into the pathology of AD and may lead to new treatment strategies.

25 Jun 2008

New mathematical model describes the structure of proteins

Proteins are the workhorses of our cells. They help to digest our food, are at the core of our immune system, and literally shape our body from top to toe. Proteins also play an important role in biotechnology in the form of enzymes, which are important in the creation of anything from pharmaceuticals to bread, washing powder and much more. Their possibilities are virtually without limit.

25 Jun 2008

New discovery could lead to new treatments for Alzheimer's

Rutgers researcher Karl Herrup and colleagues at Case Western Reserve University have discovered that a protein that suppresses cell division in brain cells effectively "puts the brakes" on the dementia that comes with Alzheimer's disease (AD). When the brakes fail, dementia results.

24 Jun 2008

New details on how low blood flow promotes vascular disease

Researchers have found the first direct proof that a key protein drives the clogging of arteries in two ways, and that lowering levels of it opens them up, according to study results published in the June edition of the journal Circulation.

24 Jun 2008

Drug rapamycin reverses mental retardation caused by tuberous sclerosis complex

UCLA researchers discovered that an FDA-approved drug reverses the brain dysfunction inflicted by a genetic disease called tuberous sclerosis complex (TSC). Because half of TSC patients also suffer from autism, the findings offer new hope for addressing learning disorders due to autism. Nature Medicine publishes the findings in its online June 22 edition.

23 Jun 2008

New, previously unrecognized source of heart stem cells discovered

Researchers at Children's Hospital Boston are continuing to document the heart's earliest origins. Now, they have pinpointed a new, previously unrecognized group of stem cells that give rise to cardiomyocytes, or heart muscle cells. These stem cells, located in the surface of the heart, or epicardium, advance the hope of being able to regenerate injured heart tissue.

23 Jun 2008

Study provides direct proof on how key protein promotes vascular disease

23 Jun 2008

Australian scientists discover digestive super bugs with potential to improve human health

Scientists in Victoria, Australia have made a world-first discovery of thousands of never-before-identified digestive super bugs living inside cows' stomachs, which may lead to environmental, agricultural and human health benefits.

17 Jun 2008

Computer predicts anti-cancer molecules

A new computer-based method of analyzing cellular activity has correctly predicted the anti-tumour activity of several molecules.

16 Jun 2008

PolyTherics and Alligator Bioscience announce strategic collaboration for optimisation of next generation biopharmaceuticals

PolyTherics Ltd, a biopharmaceutical company specialised in the targeted application of polymers to biopharmaceuticals, and Alligator Bioscience AB ("Alligator"), a biotechnology company applying proprietary technology to the improvement of proteins, today announced the establishment of a new alliance.

16 Jun 2008

Roche chlamydia test approved in Europe

Roche has announced that its new test for detection of Chlamydia trachomatis has received CE Mark certification, allowing it to be sold for clinical use in the European Union.

15 Jun 2008

Researchers find gamma-secretase modulators being tested for Alzheimer’s work in unexpected and beneficial ways

Researchers at Mayo Clinic, with their national and international collaborators, have discovered how a class of agents now in testing to treat Alzheimer's disease work, and say they may open up an avenue of drug discovery for this disease and others.

11 Jun 2008

Vitamin D, "the heart tranquilizer"

Strong bones, a healthy immune system, protection against some types of cancer: Recent studies suggest there's yet another item for the expanding list of vitamin D benefits. Vitamin D, "the sunshine vitamin," keeps the heart, the body's long-distance runner, fit for life's demands.

11 Jun 2008

Scientists identify a key regulator of DNA mutations

As a general rule, your DNA is not something you want rearranged. But there are exceptions - especially when it comes to fighting infections. Since the number of microbes in the world far surpasses the amount of human DNA dedicated to combat them, specialized cells in the immune system have adopted an ingenious, if potentially disastrous, strategy for making antibodies. These cells, called B lymphocytes, intentionally mutate their own DNA to ward off invaders they have never seen before.

9 Jun 2008

GlaxoSmithKline Acquires Sirtris Pharmaceuticals

GlaxoSmithKline has announced that it has completed its acquisition of Sirtris Pharmaceuticals, Inc. (Sirtris) for approximately USD720 million (or approx. GBP362 million) through a cash tender offer and merger of USD22.50 (or approx. GBP11.33) per share.

8 Jun 2008

Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature

Researchers have demonstrated the possibility of preventing the human malaria parasite, Plasmodium falciparum, which is responsible for more than a million malaria deaths a year, from becoming sexually mature.

5 Jun 2008

Enzyme News and Research

Novel approach for treating mitochondrial disorders wins Kaye prize

Growth-stimulating molecule called p110beta a promising cancer drug target in prostate tumors

Clinical Data secures European patent for key multi-drug resistance gene

Discovery of second genetic risk factor for developing late-onset Alzheimer's disease

Study uncovers a mechanism that explains calcium abnormalities in Alzheimer's brain

New mathematical model describes the structure of proteins

New discovery could lead to new treatments for Alzheimer's

New details on how low blood flow promotes vascular disease

Drug rapamycin reverses mental retardation caused by tuberous sclerosis complex

New, previously unrecognized source of heart stem cells discovered

Study provides direct proof on how key protein promotes vascular disease

Australian scientists discover digestive super bugs with potential to improve human health

Computer predicts anti-cancer molecules

PolyTherics and Alligator Bioscience announce strategic collaboration for optimisation of next generation biopharmaceuticals

Roche chlamydia test approved in Europe

Researchers find gamma-secretase modulators being tested for Alzheimer’s work in unexpected and beneficial ways

Vitamin D, "the heart tranquilizer"

Scientists identify a key regulator of DNA mutations

GlaxoSmithKline Acquires Sirtris Pharmaceuticals

Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature

Understanding the DNA Damage Response in Innate Immunity eBook

Shaping the Future of Neuroscience: A Conversation with Atlas Antibodies on the MolBoolean™ and the Impact of SfN 2024

How the Arts Reshape Brain Function: Susan Magsamen on the Future of Neuroaesthetics

Inside the Alzheimer's Association: Dr. Heather Snyder on Driving Research and Collaboration

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