Genome News and Research

RSS

Large DNA stretches, not single genes, shut off as cells mature

Experiments at Johns Hopkins have found that the gradual maturing of embryonic cells into cells as varied as brain, liver and immune system cells is apparently due to the shut off of several genes at once rather than in individual smatterings as previous studies have implied.

19 Jan 2009

Gene switch sites found mainly on 'shores,' not just 'islands' of the human genome

Scientists who study how human chemistry can permanently turn off genes have typically focused on small islands of DNA believed to contain most of the chemical alterations involved in those switches.

19 Jan 2009

Three new genetic variations that increase the risk of obesity

The gene variant most strongly associated with childhood obesity and adult morbid obesity in the study is located near the PTER gene, the function of which is not known. This variant is estimated to account for up to a third of all childhood obesity, and a fifth of all cases of adult obesity.

19 Jan 2009

Genetic variations in DNA repair patterns may increase risk of pancreatic cancer

Genetic variations in DNA repair patterns may increase risk of pancreatic cancer by as much as threefold or decrease it by as much as 77 percent, depending on the genes involved, according to a report published in the January 15, 2009, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.

19 Jan 2009

Defects in critical DNA repair genes may predict pancreatic cancer risk

Abnormalities in genes that repair mistakes in DNA replication may help identify people who are at high risk of developing pancreatic cancer, a research team from The University of Texas M. D. Anderson Cancer Center reports in the Jan. 15 issue of Clinical Cancer Research .

19 Jan 2009

Scientists explain genetic disease first discovered in Quebec 24 years ago

Scientists at the MUHC and McGill University have identified a gene essential for the uptake of vitamin B12 in human cells.

15 Jan 2009

Discovery of link between genetic defect on chromosome 15 and epilepsy

In a research published in the advanced online publication of the scientific magazine Nature Genetics, researchers have identified a genetic defect for common epilepsies on chromosome 15.

15 Jan 2009

Discovery of potential biomarker for smoking-related lung diseases

Researchers from Boston University School of Medicine (BUSM) have demonstrated that a recently discovered class of molecule called microRNA (miRNAs), regulate the gene expression changes in airway cells that occur with smoking and lung cancer.

13 Jan 2009

Discovery of first gender-linked susceptibility gene for late-onset Alzheimer's disease

In the Jan. 11 online edition of Nature Genetics, they report the results of their two-stage genome-wide association study of patients with Alzheimer's disease. The research showed that women who inherited two copies of a variant in the PCDH11X gene, found on the X chromosome, are at considerably greater risk of developing Alzheimer's disease.

12 Jan 2009

Researchers find genes that fuse in cancer

Using new technologies that make it easier to sequence the human genome, researchers at the University of Michigan Comprehensive Cancer Center have identified a series of genes that become fused when their chromosomes trade places with each other.

12 Jan 2009

FORMA Therapeutics to collaborate with Novartis on inhibitors

FORMA Therapeutics has announced that it has entered into a license and option agreement through the Novartis Option Fund.

12 Jan 2009

Australian discovers gene for deadly Kawasaki disease

An Australian researcher has identified genes which could make some children more susceptible to the deadly Kawasaki disease - an inflammatory condition in young children that can damage blood vessels.

12 Jan 2009

Six more obesity genes identified

The international GIANT (Genetic Investigation of Anthropometric Parameters) consortium works on the discovery of obesity genes.

8 Jan 2009

Discovery of gene that increases susceptibility to Crohn's disease

Researchers at McGill University, the Research Institute of the McGill University Health Centre (RI MUHC) and the McGill University and Génome Québec Innovation Centre, along with colleagues at other Canadian and Belgian institutions, have discovered DNA variations in a gene that increases susceptibility to developing Crohn's disease.

8 Jan 2009

New genetic markers for ulcerative colitis could lead to treatment

An international consortium of researchers, including major contribution from a team led by Dr. John D. Rioux, a professor of medicine at the Université de Montréal and the Montreal Heart Institute, has identified genetic markers associated with risk for ulcerative colitis.

8 Jan 2009

Gene abnormality found to predict childhood leukemia relapse

Scientists have identified mutations in a gene that predict a high likelihood of relapse in children with acute lymphoblastic leukemia (ALL).

8 Jan 2009

Latest genetic research on ADHD

A special issue of American Journal of Medical Genetics (AJMG): Part B: Neuropsychiatric Genetics presents a comprehensive overview of the latest progress in genetic research of Attention Deficit/Hyperactivity Disorder (ADHD).

7 Jan 2009

Genomics in China

Ten years ago, the Chinese National Human Genome Center at Shanghai (South Center, hereafter) was established in the Zhangjiang HiTech Park of Pudong District in Shanghai.

7 Jan 2009

Gene mutations found to predict acute lymphoblastic leukemia relapse

Scientists have identified mutations in a gene that predict a high likelihood of relapse in children with acute lymphoblastic leukemia (ALL).

7 Jan 2009

Widespread antiviral drug use can accelerate the evolution of drug resistance in viruses

Influenza's ability to resist the effects of cheap and popular antiviral agents in Asia and Russia should serve as a cautionary tale about U.S. plans to use the antiviral Tamiflu in the event of widespread avian flu infection in humans, scientists say.

7 Jan 2009