Protein–Protein Interactions News and Research

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Odyssey Thera granted U.S. patent for animal imaging

Odyssey Thera, Inc. has announced that the United States Patent and Trademark Office granted U.S. Patent No. 7,306,914, entitled "Protein-fragment Complementation Assays (PCA) in whole animals: applications to drug efficacy, ADME, cancer biology, immunology, infectious disease and gene therapy.

13 Dec 2007

Network approach finds potential breast cancer susceptibility gene

Like a crossword-puzzle solver who uses the letters in some answers to figure out others, researchers at Dana-Farber Cancer Institute and an international group of collaborators have used data on genes involved in inherited forms of breast cancer to identify a gene linked to non-hereditary cases of the disease.

10 Oct 2007

Simplest circadian clocks operate via orderly phosphate transfers

Researchers at Harvard University and the Howard Hughes Medical Institute have found that a simple circadian clock found in some bacteria operates by the rhythmic addition and subtraction of phosphate groups at two key locations on a single protein.

4 Oct 2007

Scientists perform computer simulation that shows how proteins vibrate in a crystal

An international collaboration directed by an Oak Ridge National Laboratory researcher has performed the first-ever atomic-detail computer simulation of how proteins vibrate in a crystal.

27 Sep 2007

New technique detects how proteins undergo changes inside a cell

In the September issue of Molecular & Cellular Proteomics , scientists describe a new technique that can detect how proteins undergo changes inside a cell.

13 Sep 2007

New chemical agent, MCP110, provides synergistic effect to standard drugs

Integrating the use of drugs targeted to specific cancer proteins into current chemotherapy regimens to improve the efficacy of systemic treatment is an important clinical goal at Fox Chase Cancer Center.

16 Apr 2007

How auxin regulates TIR1 in plants provides clues to new treatments for human diseases

For the first time, scientists from the University of Washington School of Medicine, Indiana University Bloomington and the University of Cambridge have determined how a plant hormone -- auxin -- interacts with its hormone receptor, called TIR1.

5 Apr 2007

Archemix granted two European patents

Archemix has announced today the issuance of two key, broad patents by the European Patent Office ("EPO"). The patents, EP 0 786 469 and EP 0 668 931, broadly cover methods for the identification and use of aptamers for therapeutic applications.

8 Mar 2007

Discovery of protein complex that plays important role in organ formation, cellular development and cicatrisation processes

Cellular movements are essential in organ formation processes, in cellular development and cicatrisation processes.

18 Jan 2007

Important advance in understanding the complex interactions between proteins

Interactions between proteins are the engines that drive the lives of cells, and a better understanding of these relationships -- and the structures that enable them -- are the next great frontier in the biological sciences.

10 Apr 2006

Analysis of protein interactions dispels old notions of what's important about them

Discoveries made during the first large-scale analysis of interactions between proteins in our cells hold promise for identifying new genes involved in genetic diseases, according to researchers at Johns Hopkins and the Institute of Bioinformatics (IOB) in Bangalore.

27 Feb 2006

Firefly protein lets researchers monitor molecule known as IKK (for IKappa kinase) linked to cancer

Scientists have used a glowing protein from fireflies to observe the activity of a molecule that is an important target for new drugs to treat cancer, autoimmune diseases and several other disorders.

9 Aug 2005

Unique arrays of proteins tethered onto self-assembled DNA nanostructures

In the fifty-year history since the structure of DNA was first revealed, what was once a Nobel prize- winning research discovery has become an omnipresent cultural icon co-opted for promoting everything from fragrances to musical acts.

20 Jun 2005

Protein to protein interaction map for a better insight in cancer development

With the completion of the genome sequence of a number of organisms, analysis of the gene products, the proteins, is the on-going challenge.

28 Feb 2005

Study links a novel protein pathway to the aggressive progression of breast cancer

Cytogen Corporation today announced the publication of a study linking a novel protein pathway to the aggressive progression of breast cancer.

24 Nov 2004

Trojan horse technique offers potential new therapeutic approach to Alzheimer's disease

A potential new therapeutic approach to Alzheimer's disease protects brain cells in culture by drastically reducing the neurotoxic amyloid protein aggregates that are critical to the development of the disease.

29 Oct 2004

Researchers have successfully targeted an HIV protein that has eluded existing therapies

Researchers targeted Nef, a protein responsible for accelerating the development of acquired immunodeficiency syndrome, or AIDS. Nef was targeted with small molecules synthesized by the researchers – molecules that disrupted Nef’s interaction with other proteins.

26 Sep 2004

New software helps understanding of protein-protein docking

These algorithms enable more efficient life science research by helping scientists to understand the action of therapeutically interesting proteins by predicting the manner in which two proteins interact at the atomic level.

15 Jun 2004