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Dana-Farber, Brigham and Women's Cancer Center certified to offer new CAR T-cell therapy

Following a successful clinical trial involving Dana-Farber Cancer Institute and Brigham and Women's Hospital, the first chimeric antigen receptor (CAR) T-cell therapy for adult cancers was approved by the Food and Drug Administration today.

20 Oct 2017

Experts create quality improvement blueprint to reduce repetitive lab tests for hospitalized patients

In a review article publishing this week in JAMA Internal Medicine, physicians at Johns Hopkins, along with experts from several other institutions across north America, compiled published evidence and crafted an experience-based quality improvement blueprint to reduce repetitive lab testing for hospitalized patients.

20 Oct 2017

Suspected plague cases from Seychelles tested negative at WHO partner laboratory

Samples from patients in Seychelles suspected to be ill with pneumonic plague tested negative at a World Health Organization partner laboratory in Paris, France on Tuesday (17 October).

20 Oct 2017

British biotech calls for faster regulatory process to tackle AMR threat

Representing small and medium-sized companies, Ian Staples, Chief Executive of British biotech Matoke Holdings, called on the House of Lords Science and Technology Committee to help ensure that life-saving drugs can get through the regulatory process faster. The Committee was taking evidence as part of its ‘Life Sciences and the Industrial Strategy’ inquiry.

20 Oct 2017

Penn researchers functionally dissect gene variant linked to FTLD

Seven years ago, Penn Medicine researchers showed that mutations in the TMEM106B gene significantly increased a person's risk of frontotemporal lobar degeneration (FTLD), the second most common cause of dementia in those under 65.

19 Oct 2017

New RNA switch achieves gene activation thousands of times better than nature

If scientists could precisely regulate gene expression, they could turn off the genes responsible for illness and disease and turn on those that enhance health and the immune system.

19 Oct 2017

UCSD researchers discover how mutant gene amplifies inflammation to fuel cancer

A human gene called p53, which is commonly known as the "guardian of the genome," is widely known to combat the formation and progression of tumors. Yet, mutant forms of p53 have been linked to more cases of human cancer than any other gene.

19 Oct 2017

Scientists uncover surprising molecular link in critical cellular growth pathway

A team of scientists led by Whitehead Institute has uncovered a surprising molecular link that connects how cells regulate growth with how they sense and make available the nutrients required for growth.

19 Oct 2017

New procedure expands options open for carrying out tests on human brain cells

Researchers at the University of Tübingen have become the first to keep human brain tissue alive outside the body for several weeks.

19 Oct 2017

Brazilian researchers find more significant cognitive deficits among early-onset cocaine users

People who begin using cocaine during adolescence display more significant cognitive deficits than people who begin using the drug in adulthood.

18 Oct 2017

Four genes associated with OCD identified

There are found genes that have been identified to be associated with obsessive compulsive disorder (OCD). These genes have been found to alter the circuitry of the brain in a manner that could lead to OCD. These genetic links also point to the fact why OCD sometimes runs in families. The study is published in the latest issue of Nature Communications.

18 Oct 2017

Two studies set groundwork for new avenues to treat influenza and anthrax poisoning

Two recent studies led by biologists at the University of California San Diego have set the research groundwork for new avenues to treat influenza and anthrax poisoning

17 Oct 2017

Researchers use powerful X-ray beams for ‘navigational map view’ of mouse brain

If brain imaging could be compared to Google Earth, neuroscientists would already have a pretty good "satellite view" of the brain, and a great "street view" of neuron details.

17 Oct 2017

Arsenic trioxide could be powerful therapy to extend lives of certain glioblastoma patients

From Sherlock Holmes to Agatha Christie, arsenic is often the poison of choice in popular whodunits. But in ultra-low dosage, and in the right form, this naturally occurring chemical element can be a potent force against cancer.

17 Oct 2017

Scientists receive critical funding to study treatments for three deadly cancers

Immunotherapy for leukemia patients has been nothing short of a miracle. Now scientists hope to use that science and other forms of gene therapy to tackle three of the deadliest forms of cancer: glioblastoma (brain cancer), sarcoma (bone cancer) and ovarian cancer.

17 Oct 2017

Synthetic compound targets enzyme that supports survival and dissemination of metastatic cells

Cancer can most often be successfully treated when confined to one organ. But a greater challenge lies in treating cancer that has metastasized, or spread, from the primary tumor throughout the patient's body.

17 Oct 2017

USC study reveals how schizophrenia has biological effect on the entire brain

Some 40 years since CT scans first revealed abnormalities in the brains of schizophrenia patients, international scientists say the disorder is a systemic disruption to the brain's entire communication system.

17 Oct 2017

Using AFM to study cell mechanics and function

My lab, broadly speaking, is interested in trying to understand interactions between cells and materials. Those could be materials that are present within living tissue or materials that we use for engineering purposes to try to do something of technological or therapeutic interest.

From Bruker Nano Surfaces and Metrology 17 Oct 2017

Novel gene expression signature assay could help enhance lymphoma management

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer and the most frequently diagnosed non-Hodgkin lymphoma worldwide (nearly 40% of cases). Recent advancements indicate that both the prognosis and choice of treatment of DLBCL may depend on identifying its molecular subtype.

17 Oct 2017

BU researcher wins NIH award for research on molecular mechanism of senile cardiac amyloidosis

Lawreen H. Connors, PhD, associate professor of pathology and laboratory medicine and biochemistry at Boston University School of Medicine, is the recipient of a National Institutes of Health High Priority, Short-Term Project Award, for her research "molecular mechanism of senile cardiac amyloidosis."

16 Oct 2017

Laboratory News and Research

Dana-Farber, Brigham and Women's Cancer Center certified to offer new CAR T-cell therapy

Experts create quality improvement blueprint to reduce repetitive lab tests for hospitalized patients

Suspected plague cases from Seychelles tested negative at WHO partner laboratory

British biotech calls for faster regulatory process to tackle AMR threat

Penn researchers functionally dissect gene variant linked to FTLD

New RNA switch achieves gene activation thousands of times better than nature

UCSD researchers discover how mutant gene amplifies inflammation to fuel cancer

Scientists uncover surprising molecular link in critical cellular growth pathway

New procedure expands options open for carrying out tests on human brain cells

Brazilian researchers find more significant cognitive deficits among early-onset cocaine users

Four genes associated with OCD identified

Two studies set groundwork for new avenues to treat influenza and anthrax poisoning

Researchers use powerful X-ray beams for ‘navigational map view’ of mouse brain

Arsenic trioxide could be powerful therapy to extend lives of certain glioblastoma patients

Scientists receive critical funding to study treatments for three deadly cancers

Synthetic compound targets enzyme that supports survival and dissemination of metastatic cells

USC study reveals how schizophrenia has biological effect on the entire brain

Using AFM to study cell mechanics and function

Novel gene expression signature assay could help enhance lymphoma management

BU researcher wins NIH award for research on molecular mechanism of senile cardiac amyloidosis

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