Therapeutics News and Research

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Colon cancer may benefit from hormone replacement therapy

Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have found new evidence suggesting that colon cancer is actually a disease of missing hormones that could potentially be treated by hormone replacement therapy.

2 Aug 2007

VAC therapy for wound healing questioned

The effectiveness and value of an increasingly popular treatment used in the treatment of long term wounds are questioned in this month's Drug and Therapeutics Bulletin (DTB)

1 Aug 2007

Lithium promotes better bone healing

Researchers at The Hospital for Sick Children (SickKids) have found a molecular pathway that plays a critical role in bone healing and have found that the drug lithium can improve the healing process.

1 Aug 2007

Nanoparticles may provide safe pain control on the battlefield

University of Michigan scientists have received a pilot grant of nearly $1.3 million from the Defense Advanced Research Projects Agency to test whether nanoparticles can solve a pressing problem in battle zones like Iraq: how to administer sustained, safe doses of the most effective painkillers to injured soldiers, long before they can reach expert medical help.

1 Aug 2007

Zebrafish provide clues to cure for Lou Gehrig's disease

A small tropical fish, the curiosity of a Geisinger research scientist and some college students have created the perfect storm of sorts in an attempt to find a cure for one of the world's most devastating neurological diseases.

1 Aug 2007

New facility for biotechnology and life science companies

The University of Rochester Medical Center (URMC) has announced the dedication of a new facility that will support the development of early stage biotechnology and life science companies.

25 Jul 2007

New insight into cell division and chromosones

St. Jude investigators have used the lowly yeast to gain insights into how a dividing human cell ensures that an identical set of chromosomes gets passed on to each new daughter cell.

23 Jul 2007

Koronis Pharmaceuticals issued U.S. patent for KP-1461 therapeutic in development for treatment of HIV

Koronis Pharmaceuticals, Inc. has announced the issuance of U.S. Patent No. 7,244,732 that discloses the composition of KP-1461 -- the Company's lead antiviral therapeutic currently in a Phase 2 trial for the treatment of human immunodeficiency virus (HIV) infection.

23 Jul 2007

Schering-Plough announces licensing of Acadesine

Schering-Plough Corporation has announced the worldwide licensing of acadesine, an investigational, potentially first-in-class adenosine regulating agent (ARA), from PeriCor Therapeutics, Inc., a privately held, specialty biopharmaceutical company.

20 Jul 2007

Tibotec Pharmaceuticals submits NDA for investigational HIV treatment

Tibotec Pharmaceuticals Ltd. has announced the submission of a New Drug Application to the U.S. Food and Drug Administration (FDA) for TMC125 (etravirine), an investigational non- nucleoside reverse transcriptase inhibitor (NNRTI), being studied for use with other antiretroviral (ARV) agents as a treatment for people infected with HIV- 1.

19 Jul 2007

Suicide gene therapy for cancer

Cutting-edge research at South Dakota State University may yield a new therapy that targets only cancer cells, leaving healthy cells unharmed.

18 Jul 2007

Orchestra Therapeutics discontinues HIV vaccine program

Orchestra Therapeutics, Inc. has announced the discontinuation of its HIV Vaccine Development Program.

18 Jul 2007

Impact of food-cancer drug interactions

A commentary in the Journal of Clinical Oncology (JCO) urges researchers to explore an intriguing approach to reduce the dose, and therefore the cost, of oral targeted cancer therapies.

18 Jul 2007

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

Researchers at Karolinska Institutet in Sweden have managed to elucidate the crystal structure of a human membrane protein - LTC4 synthase - which has a major influence on the development of asthma.

17 Jul 2007

UAB receives grants to investigate novel approaches to treat Parkinson's disease

The Michael J. Fox Foundation (MJFF) has awarded two research grants to UAB (University of Alabama at Birmingham) researchers to investigate novel approaches to treat Parkinson's disease.

13 Jul 2007

Chemically-modified mitochondrial toxin could lead to a new molecularly-targeted chemo drug

A chemically-modified version of a mitochondrial toxin long used to control species of invasive fish in lakes has been found to selectively inhibit two "survival proteins" in cancer cells.

12 Jul 2007

New advance in search for effective treatment for human liver cancer

Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer in the July issue of Molecular Cancer Therapeutics.

12 Jul 2007

40% of community pharmacists don't tell parents they are dispensing off-label drugs to children

Forty per cent of community pharmacists have dispensed an off-label drug to a child in the last month, according to research published in the July issue of the British Journal of Clinical Pharmacology.

12 Jul 2007

New use for a cell toxin found to inhibit survival proteins in cancer cells

A chemically-modified version of a mitochondrial toxin long used to control species of invasive fish in lakes has been found to selectively inhibit two "survival proteins" in cancer cells.

11 Jul 2007

Baxter presents findings from the ADAPT study

Baxter Healthcare Corporation has announced the presentation of findings from the ADAPT (Analysis of Data from ADVATE Prospective Trials) study program database showing a statistically significant relationship between the duration of time spent with factor VIII blood levels below one international unit per deciliter (1 IU/dL, one percent of normal factor VIII level) and an increase in the annual bleed rate in people with hemophilia A.

11 Jul 2007