Small Molecules News and Research

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Pins made of single atoms to fight cancer

Answers are often elusive in the fight against cancer, and Rice University chemist Zachary Ball is hoping to pin one down -- with pins made of single atoms. The work, which aims to create a drug that's effective against an "undruggable" protein, is one of the first 50 proposals funded under the National Cancer Institute's (NCI) Provocative Questions Project.

31 Oct 2012

Maternal bariatric surgery affects cardiovascular risk profile of offsprings

Kids born to moms who have lost a substantial amount of weight after undergoing bariatric surgery have fewer cardiovascular risk factors than their siblings who were born before the weight loss surgery.

29 Oct 2012

Researchers learn how E2-79 molecule destroys complexes that induce allergic responses

Researchers have learned how a man-made molecule destroys complexes that induce allergic responses - a discovery that could lead to the development of highly potent, rapidly acting interventions for a host of acute allergic reactions.

29 Oct 2012

Study describes how Dbr1 gene halts toxic buildup of TDP-43-a protein

Scientists at the Gladstone Institutes and the Stanford University School of Medicine have discovered how modifying a gene halts the toxic buildup of a protein found in nerve cells. These findings point to a potential new tactic for treating a variety of neurodegenerative conditions, including amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease)-a fatal disease for which there is no cure.

29 Oct 2012

TSRI scientists to study structural rules that govern nuclear receptors

A consortium of scientists from both campuses of The Scripps Research Institute (TSRI) has been awarded $2.7 million from the National Institute of General Medical Sciences of the National Institutes of Health to study the structural rules that govern a large superfamily of proteins that help regulate critical functions such as reproduction, development and metabolism.

24 Oct 2012

Salk findings on cold virus proteins may spur new cancer treatments

Cold viruses generally get a bad rap----which they've certainly earned----but new findings by a team of scientists at the Salk Institute for Biological Studies suggest that these viruses might also be a valuable ally in the fight against cancer.

17 Oct 2012

Positive results from PROLOR's Rpeg preclinical toxicology study

PROLOR Biotech, Inc. today announced positive results from a preclinical toxicology study designed to assess the safety and tolerability of PROLOR's proprietary long-acting reversible-pegylation technology.

17 Oct 2012

Scientists discover mechanism used by A20 protein to combat inflammation

Scientists affiliated with VIB and UGent have discovered a mechanism used by the protein A20 to combat inflammation. This could be a very important point of focus in the search for a treatment for autoimmune diseases such as Rheumatoid Arthritis, in which the patient suffers from chronic, uncontrolled inflammation.

10 Oct 2012

Researchers identify two new small 'chaperone' molecules that may treat Schindler/Kanzaki disease

University of Massachusetts Amherst researchers, experts in revealing molecular structure by X-ray crystallography, have identified two new small "chaperone" molecules that may be useful in treating the inherited metabolic disorder known as Schindler/Kanzaki disease.

10 Oct 2012

New screening method may lead to more efficient RNA drug development

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new method of screening more than three million combinations of interactions between RNA and small molecules to identify the best targets on RNA as well as the most promising potential drug compounds.

10 Oct 2012

Inhibiting DUSP6 protein can restore immune cells’ responsiveness to a more youthful state

The older we get, the weaker our immune systems tend to become, leaving us vulnerable to infectious diseases and cancer and eroding our ability to benefit from vaccination. Now Stanford University School of Medicine scientists have found that blocking the action of a single protein whose levels in our immune cells creep steadily upward with age can restore those cells' response to a vaccine.

1 Oct 2012

Researchers identify several kinase inhibitors that help generate many iPSCs

The process researchers use to generate induced pluripotent stem cells (iPSCs)-a special type of stem cell that can be made in the lab from any type of adult cell-is time consuming and inefficient. To speed things up, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) turned to kinase inhibitors.

26 Sep 2012

UCSD bioengineers to play a central role in new NIH program to accelerate metabolomics

With a $6 million grant over five years, bioengineers from the University of California, San Diego will play a central role in a new program from the National Institutes of Health (NIH) to accelerate "metabolomics", an emerging field of biomedical research that offers a path to a wealth of information about a person's nutrition, infection, health, disease status and more.

25 Sep 2012

PNAS: Ras proteins bring tension to the phosphate chain

Proteins accelerate certain chemical reactions in cells by several orders of magnitude. The molecular mechanism by which the Ras protein accelerates the cleavage of the molecule GTP and thus slows cell growth is described by biophysicists at the Ruhr-Universit-t Bochum led by Prof. Dr. Klaus Gerwert in the Online Early Edition of the journal PNAS.

20 Sep 2012

Novel serum assay measures calcification risk

Researchers have devised a nephelometer-based assay that measures the risk for calcification in serum samples.

12 Sep 2012

Heptares uses StaR technology to solve structure of CRF-1 receptor

Heptares Therapeutics today announces that it has used its StaR technology to solve entirely in-house the first structure of a Family B sub-class G protein-coupled receptor (GPCR).

10 Sep 2012

Scripps Florida designs new compound that shows promise against tremor ataxia syndrome

Scientists on the Florida campus of The Scripps Research Institute have designed a compound that shows promise as a potential therapy for one of the diseases closely linked to fragile X syndrome, a genetic condition that causes mental retardation, infertility, and memory impairment, and is the only known single-gene cause of autism.

6 Sep 2012

Small Molecules News and Research

Pins made of single atoms to fight cancer

Maternal bariatric surgery affects cardiovascular risk profile of offsprings

Researchers learn how E2-79 molecule destroys complexes that induce allergic responses

Study describes how Dbr1 gene halts toxic buildup of TDP-43-a protein

TSRI scientists to study structural rules that govern nuclear receptors

Salk findings on cold virus proteins may spur new cancer treatments

Positive results from PROLOR's Rpeg preclinical toxicology study

Scientists discover mechanism used by A20 protein to combat inflammation

Researchers identify two new small 'chaperone' molecules that may treat Schindler/Kanzaki disease

New screening method may lead to more efficient RNA drug development

Inhibiting DUSP6 protein can restore immune cells’ responsiveness to a more youthful state

Researchers identify several kinase inhibitors that help generate many iPSCs

UCSD bioengineers to play a central role in new NIH program to accelerate metabolomics

PNAS: Ras proteins bring tension to the phosphate chain

Novel serum assay measures calcification risk

Heptares uses StaR technology to solve structure of CRF-1 receptor

Scripps Florida designs new compound that shows promise against tremor ataxia syndrome

TSC and PTEN genes important in controlling blood precursor cells in Drosophila

FDA grants orphan designation to Aerial BioPharma’s ARL-N05 for treatment of narcolepsy

Understanding photoreceptor proteins could lead to cancer drug therapy

Shaping the Future of Neuroscience: A Conversation with Atlas Antibodies on the MolBoolean™ and the Impact of SfN 2024

How the Arts Reshape Brain Function: Susan Magsamen on the Future of Neuroaesthetics

Inside the Alzheimer's Association: Dr. Heather Snyder on Driving Research and Collaboration

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