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Seven-year quest to understand how breast cancer cells resist treatment

A seven-year quest to understand how breast cancer cells resist treatment with the targeted therapy lapatinib has revealed a previously unknown molecular network that regulates cell death.

8 May 2013

Study shows patient selection based on biosamples makes clinical trials more efficient, reduces costs

Researchers at Moffitt Cancer Center say identifying and selecting participants for phase II cancer clinical trials from a centralized warehouse of patient-donated biological data expedites participant accrual, reduces trial size, saves money, and may speed test drugs through the drug development pipeline.

8 May 2013

Scientists identify TR4 protein that drives the formation of pituitary tumors in Cushing's disease

Scientists at the Salk Institute for Biological Studies have identified a protein that drives the formation of pituitary tumors in Cushing's disease, a development that may give clinicians a therapeutic target to treat this potentially life-threatening disorder.

8 May 2013

Study shows turning up few microRNAs may offer much anti-breast-cancer activity

A University of Colorado Cancer Center study recently published in the journal Cell Death & Disease shows that turning up a few microRNAs a little may offer as much anti-breast-cancer activity as turning up one microRNA a lot - and without the unwanted side effects.

8 May 2013

Clinical data of cabozantinib to be presented at ASCO meeting

Exelixis, Inc. announced today that cabozantinib will be the subject of nine separate data presentations at the upcoming 2013 Annual Meeting of the American Society of Clinical Oncology.

8 May 2013

Advances in lung cancer treatment have major impact on short- and long-term outcomes

The American College of Chest Physicians third edition of evidence-based lung cancer guidelines, Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, recommends offering low-dose computed tomography scanning for lung cancer screening to people with a significant risk of lung cancer due to age and smoking history.

8 May 2013

Isis begins clinical study of ISIS-STAT3 in patients with metastatic liver cancer

Isis Pharmaceuticals, Inc. announced the initiation of a Phase 1b/2a clinical study of ISIS-STAT3Rx in patients with advanced metastatic hepatocellular carcinoma (HCC).

7 May 2013

Entremed reports patent issuance for its lead drug candidate ENMD-2076

EntreMed, Inc., a clinical-stage pharmaceutical company developing therapeutics for the treatment of a variety of cancers, today announced the issuance by the Chinese State Intellectual Property Office of Patent Certificate No. ZL 200680044656.7.

7 May 2013

Mutations in phosphatase Wip1 could be a new target for treating cancer

Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new target for the treatment of certain cancers.

6 May 2013

Tipsheet of story ideas from Cedars-Sinai Medical Center

In an effort to better protect women from heart disease, Irene Pollin, a widely respected public health advocate who founded the nation's first organization dedicated to preventing heart disease in women, has donated $10 million to the Barbra Streisand Women's Heart Center at the Cedars-Sinai Heart Institute.

6 May 2013

High levels of collagen in breasts are associated with breast cancer metastasis

Researchers at Washington University School of Medicine in St. Louis have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread.

6 May 2013

Incidence of testicular cancer on rise among American males

The incidence of testicular cancer has increased among American males over 15 years of age for more than 20 years and while overall incidence is still highest among Caucasian males, the greatest increase was observed in the Hispanic community, according to a new study at the 108th Annual Scientific Meeting of the American Urological Association.

5 May 2013

Novel screening method for identifying inhibitors of EZH2 methyltransferase

Tumor repressor genes, which inhibit tumor formation, can be "turned off" due to undesirable molecular changes affecting the chromosomes on which the genes reside. Understanding and being able to control these alterations could lead to new approaches for activating or inactivating genes linked to cancer.

5 May 2013

Expert to explain how drugs induce damage to DNA in public lecture on May 16

Anticancer drugs save lives and/or improve the quality of life for many cancer patients. Many anti-cancer drugs work by killing tumor cells after inducing damage to DNA.

4 May 2013

Newly discovered ‘master regulator’ gene may help develop novel treatment for drug-resistant tumors

Researchers at Johns Hopkins have identified a gene that, when repressed in tumor cells, puts a halt to cell growth and a range of processes needed for tumors to enlarge and spread to distant sites. The researchers hope that this so-called "master regulator" gene may be the key to developing a new treatment for tumors resistant to current drugs.

3 May 2013

New computational method for assessing lung cancer tumors

Moffitt Cancer Center and the University of South Florida have collaborated with researchers in China, the United Kingdom, the Netherlands and Germany to devise a new computational method for assessing lung cancer tumors using CT, PET or MRI diagnostic technologies.

3 May 2013

New technology to study interactions between metal elements, molecules in living organisms

Metal elements and molecules interact in the body but visualizing them together has always been a challenge. Researchers from the RIKEN Center for Life Science Technologies in Japan have developed a new molecular imaging technology that enables them to visualize bio-metals and bio-molecules simultaneously in a live mouse.

3 May 2013

Cancer Genetics introduces proprietary urogenital cancer array for diagnosing kidney cancer

Cancer Genetics, Inc., a leader in oncology-focused personalized medicine, has launched a proprietary urogenital cancer array, UroGenRA, intended for kidney cancer diagnosis and subtyping in its own laboratory.

3 May 2013

Researchers find association between DCIS Score and risk of developing IBE

The ductal carcinoma in situ Score quantifies the risk of ipsilateral breast event and invasive IBE risk, complements both traditional clinical and pathologic factors, and helps provide a new clinical tool to improve the process of selecting individualized treatment for women with DCIS who meet the criteria, according to a study published May 2 in the Journal of the National Cancer Institute.

3 May 2013

Research findings suggest new treatment for breast, colon, melanoma and other cancers

A common cancer pathway causing tumor growth is now being targeted by a number of new cancer drugs and shows promising results.

3 May 2013

Tumor News and Research

Seven-year quest to understand how breast cancer cells resist treatment

Study shows patient selection based on biosamples makes clinical trials more efficient, reduces costs

Scientists identify TR4 protein that drives the formation of pituitary tumors in Cushing's disease

Study shows turning up few microRNAs may offer much anti-breast-cancer activity

Clinical data of cabozantinib to be presented at ASCO meeting

Advances in lung cancer treatment have major impact on short- and long-term outcomes

Isis begins clinical study of ISIS-STAT3 in patients with metastatic liver cancer

Entremed reports patent issuance for its lead drug candidate ENMD-2076

Mutations in phosphatase Wip1 could be a new target for treating cancer

Tipsheet of story ideas from Cedars-Sinai Medical Center

High levels of collagen in breasts are associated with breast cancer metastasis

Incidence of testicular cancer on rise among American males

Novel screening method for identifying inhibitors of EZH2 methyltransferase

Expert to explain how drugs induce damage to DNA in public lecture on May 16

Newly discovered ‘master regulator’ gene may help develop novel treatment for drug-resistant tumors

New computational method for assessing lung cancer tumors

New technology to study interactions between metal elements, molecules in living organisms

Cancer Genetics introduces proprietary urogenital cancer array for diagnosing kidney cancer

Researchers find association between DCIS Score and risk of developing IBE

Research findings suggest new treatment for breast, colon, melanoma and other cancers

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