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Japan's MHLW approves XELJANZ for treatment of adults with rheumatoid arthritis

Pfizer Inc. announced today that the Japanese Ministry of Health, Labor and Welfare has approved XELJANZ (tofacitinib citrate) for the treatment of adults with rheumatoid arthritis who have had an inadequate response to existing therapies.

25 Mar 2013

Researchers expand hematopoietic stem cells for bone marrow transplantation

More than 50,000 stem cell transplants are performed each year worldwide. A research team led by Weill Cornell Medical College investigators may have solved a major issue of expanding adult hematopoietic stem cells (HSCs) outside the human body for clinical use in bone marrow transplantation -- a critical step towards producing a large supply of blood stem cells needed to restore a healthy blood system.

25 Mar 2013

Research may offer clues to why esophageal adenocarcinomas rates have increased rapidly

During the past 30 years, the number of patients with cancers that originate near the junction of the esophagus and stomach has increased approximately 600 percent in the United States. The first extensive probe of the DNA of these esophageal adenocarcinomas has revealed that many share a distinctive mix-up of letters of the genetic code, and found more than 20 mutated genes that had not previously been linked to the disease.

25 Mar 2013

Researchers identify patterns of mutations in early stage node negative lung adenocarcinoma

Molecular driven therapeutic targets have resulted in a paradigm shift in the treatment of advanced lung adenocarcinoma. However, in early non-small cell lung cancer, surgical resection remains the treatment of choice with adjuvant chemotherapy.

25 Mar 2013

SLU researcher studies effect of bitter melon extract on treating cancer

A Saint Louis University researcher has received a $39,425 grant from the Lottie Caroline Hardy Charitable Trust to continue her research on treating cancer with a natural substance -- the extract taken from a vegetable that is part of her diet.

24 Mar 2013

Study of genetically modified immune cells could help improve promising treatment for melanoma

A new study of genetically modified immune cells by scientists from UCLA and the California Institute of Technology could help improve a promising treatment for melanoma, an often fatal form of skin cancer.

24 Mar 2013

By charting differing fates of individual T cells, researchers show unpredictable aspects of immune response

By charting the differing fates of individual T cells, researchers have shown that previously unpredictable aspects of the adaptive immune response can be effectively modeled.

21 Mar 2013

Disinfectant mouthwashes may be effective against cancers of the mouth and throat

Patients who suffer from gingivitis are often advised to use disinfectant mouthwashes. In the future, the active ingredients in these products could be used in a completely different area: As scientists have reported in the journal Angewandte Chemie, Chlorhexidin and Alexidin increase programmed cell death and may be effective against cancers of the mouth and throat.

21 Mar 2013

New research provides better understanding of preserving brain's functions while killing cancer

New research from Wake Forest Baptist Medical Center is giving radiation oncologists who treat brain tumors a better understanding of how to preserve the brain's functions while still killing cancer.

21 Mar 2013

New imaging agent detects, maps cancers that have reached lymph nodes

Researchers at the University of California, San Diego School of Medicine have shown that a new imaging dye, designed and developed at UC San Diego Moores Cancer Center, is an effective agent in detecting and mapping cancers that have reached the lymph nodes.

21 Mar 2013

Researchers complete phase II clinical trial of dasatinib for patients with higher-risk MDS

Researchers at Moffitt Cancer Center have completed a phase II clinical trial to determine the safety and efficacy of dasatinib for patients with higher-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, or acute myeloid leukemia resulting from MDS and have failed treatment with azanucleosides.

21 Mar 2013

Genetically modified tomatoes mimic actions of good cholesterol

UCLA researchers have genetically engineered tomatoes to produce a peptide that mimics the actions of good cholesterol when consumed.

20 Mar 2013

Antagonist drug Emend halts brain tumor growth

New research from the University of Adelaide has shown for the first time that the growth of brain tumors can be halted by a drug currently being used to help patients recover from the side effects of chemotherapy.

20 Mar 2013

Protein derived from Pacific cod may inhibit prostate cancer, researchers say

Researchers at the University of Maryland School of Medicine have identified a peptide, or protein, derived from Pacific cod that may inhibit prostate cancer and possibly other cancers from spreading, according to preclinical research published online in the Proceedings of the National Academy of Sciences.

20 Mar 2013

Study assesses effectiveness of modern mammography screening in breast cancer

Kerlikowske et al., recently published in the Journal of the American Medical Association, used obsolete clinical endpoints to assess effectiveness of modern mammography screening and is fundamentally flawed regarding participant selection in the two study groups (annually vs. biennially).

19 Mar 2013

Tivozanib: an interview with Stephen L. Eck, M.D., Ph.D., Vice President, Global Oncology, Astellas Pharma US, Inc. Global Development

Tivozanib is an oral, once-daily, investigational tyrosine kinase inhibitor, or TKI, that is being investigated for use in patients with advanced renal cell carcinoma (RCC), or kidney cancer.

19 Mar 2013

Research reveals immortality gene mutation plays pivotal role in brain tumors, other cancers

Newly identified mutations in a gene that makes cells immortal appear to play a pivotal role in three of the most common types of brain tumors, as well as cancers of the liver, tongue and urinary tract, according to research led by Duke Cancer Institute.

19 Mar 2013

Mesenchymal stem cells safe, effective for treating poor graft function: Study

When a research team in China evaluated the efficacy and safety of using mesenchymal stem cells expanded from the bone marrow of non-self-donors to treat patients experiencing poor graft function after receiving transplants of non-self-donated blood stem cells (allo-HSCT), they found that the mesenchymal stem cells were both safe and effective for treating primary and secondary PGF.

19 Mar 2013

Study reveals potential markers for treating patients with metastatic clear cell RCC

Markers such as CA9, CD31, CD34 and VEGFR1/2 in the primary tumours might serve as predictors of a good response to a sunitinib treatment in patients with metastatic clear cell renal cell carcinoma (ccRCC), according to a new study to be presented at the 28th Annual EAU Congress currently on-going in Milan.

18 Mar 2013

Columbia University Medical Center, NewYork-Presbyterian Hospital present research works at AAN meeting

The following research from Columbia University Medical Center and NewYork-Presbyterian Hospital is being presented at the 65th annual meeting of the American Academy of Neurology, March 16-23, 2013, in San Diego.

18 Mar 2013

Tumor News and Research

Japan's MHLW approves XELJANZ for treatment of adults with rheumatoid arthritis

Researchers expand hematopoietic stem cells for bone marrow transplantation

Research may offer clues to why esophageal adenocarcinomas rates have increased rapidly

Researchers identify patterns of mutations in early stage node negative lung adenocarcinoma

SLU researcher studies effect of bitter melon extract on treating cancer

Study of genetically modified immune cells could help improve promising treatment for melanoma

By charting differing fates of individual T cells, researchers show unpredictable aspects of immune response

Disinfectant mouthwashes may be effective against cancers of the mouth and throat

New research provides better understanding of preserving brain's functions while killing cancer

New imaging agent detects, maps cancers that have reached lymph nodes

Researchers complete phase II clinical trial of dasatinib for patients with higher-risk MDS

Genetically modified tomatoes mimic actions of good cholesterol

Antagonist drug Emend halts brain tumor growth

Protein derived from Pacific cod may inhibit prostate cancer, researchers say

Study assesses effectiveness of modern mammography screening in breast cancer

Tivozanib: an interview with Stephen L. Eck, M.D., Ph.D., Vice President, Global Oncology, Astellas Pharma US, Inc. Global Development

Research reveals immortality gene mutation plays pivotal role in brain tumors, other cancers

Mesenchymal stem cells safe, effective for treating poor graft function: Study

Study reveals potential markers for treating patients with metastatic clear cell RCC

Columbia University Medical Center, NewYork-Presbyterian Hospital present research works at AAN meeting

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