Small Molecules News and Research

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Structure of human P-glycoprotein in a moving 3D computer model

A picture is worth 1,000 words when it comes to understanding how things work, but 3D moving pictures are even better. That's especially true for scientists trying to stop cancer by better understanding the proteins that make some chemotherapies unsuccessful.

21 Jun 2012

Researchers unlock structure of STING protein

Researchers at Weill Cornell Medical College have unlocked the structure of a key protein that, when sensing certain viruses and bacteria, triggers the body's immediate immune response.

20 Jun 2012

Ambrx, Merck collaborate to develop and commercialize biotherapeutic drug conjugates

Ambrx today announced that the company has entered into a collaboration with Merck to design and develop rationally optimized biologic drug conjugates based on Ambrx's site-specific protein medicinal chemistry technology.

18 Jun 2012

NIH awards $9 million grant to study aging and immunity to infections

The Trudeau Institute today announced that faculty member Laura Haynes, Ph.D., was awarded a grant from the National Institutes of Health (NIH) to study how aging impacts the immune system's response to influenza infection and vaccination.

15 Jun 2012

Fate Therapeutics, BD Biosciences introduce first collaborative iPSC-related product

Fate Therapeutics, Inc. in collaboration with BD Biosciences, a segment of BD (Becton, Dickinson and Company), today announced the introduction of the first induced pluripotent stem cell (iPSC)-related product resulting from the collaboration between the two companies.

From BD (Becton, Dickinson and Company) 11 Jun 2012

Researchers devise strategy to directly activate natural ‘death’ protein

Researchers at Dana-Farber/Children's Hospital Cancer Center have devised a strategy to directly activate a natural "death" protein, triggering the self-destruction of cells. They say the development could represent a new paradigm for designing cancer drugs.

1 Jun 2012

Ensemble, Genentech enter macrocyclic drug discovery collaboration

Ensemble Therapeutics, a biotechnology company developing Ensemblins, a novel class of small molecule therapeutics with the power of biologics, today announced the initiation of a drug discovery collaboration with Genentech, a member of the Roche Group, to discover macrocyclic drug candidates against targets specified by Genentech.

29 May 2012

Cardiomyocytes can now be made cheaply and abundantly in the laboratory

Cardiomyocytes, the workhorse cells that make up the beating heart, can now be made cheaply and abundantly in the laboratory.

29 May 2012

Thermo Scientific Watson LIMS offers enhanced functionality for bioanalytical laboratories

Thermo Fisher Scientific Inc., the world leader in serving science, today announced that its Thermo Scientific Watson LIMS (laboratory information management system) offers enhanced functionality for large molecule bioanalysis in pharmaceutical and contract research organization (CRO) laboratories.

From Thermo Fisher Scientific Inc. 22 May 2012

Ventac and GIBH announce creation of CASiGEN Pharma

Ventac Partners and the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences (GIBH) today announced the creation of CASiGEN Pharma Ltd. (CASiGEN) to bring new treatments for diabetes and other metabolic disorders to the global market.

18 May 2012

AAD reiterates safety and effectiveness of sunscreens against UV radiation

The American Academy of Dermatology (Academy) today reiterated the safety and effectiveness of sunscreens to protect against the damaging effects from exposure to ultraviolet (UV) radiation.

16 May 2012

MicroRNA-3151 a new independent prognostic marker for acute leukemia

A study has identified microRNA-3151 as a new independent prognostic marker in certain patients with acute leukemia. The study involves patients with acute myeloid leukemia and normal-looking chromosomes.

15 May 2012

TGen to lead multidisciplinary search for new drugs that could help treat GBM

The Translational Genomics Research Institute (TGen) will lead a multidisciplinary search for new drugs that could help treat the most common and lethal form of brain cancer.

4 May 2012

NJIT professor receives $340,000 NIH grant to investigate membrane proteins

NJIT Associate Professor Edgardo Farinas has been awarded today a three-year $340,000 National Institutes of Health (NIH) grant to investigate spores as a protein display platform for the directed evolution of membrane proteins.

3 May 2012

New bio-inspired approach can synthesize polymers

A new bio-inspired approach to synthesising polymers will offer unprecedented control over the final polymer structure and yield advances in nanomedicine, researchers say.

3 May 2012

Novo Nordisk granted exclusive rights to Caisson's heparosan-based drug delivery technology

Caisson Biotech, L.L.C., a biopharmaceutical company with a patented heparosan-based drug delivery technology, announced today that it has entered into a Development and License Agreement with Novo Nordisk A/S, a global healthcare company and leader in diabetes care.

From Novo Nordisk 2 May 2012

Researchers discover small molecules that kill HPV-infected cancer cells

Researchers at The Wistar Institute announce the discovery of small molecules that kill cancer cells caused by infection with human papillomavirus (HPV). Their results, in both cell and mouse models, demonstrate that the small molecule inhibitors protect a tumor-suppressing protein targeted by viral proteins, thus killing the infected tumor cells.

27 Apr 2012

Scripps Florida scientist to develop new tests for aging and stress-associated diseases

A scientist from the Florida campus of The Scripps Research Institute has been awarded just over $1 million from the National Institutes of Health to develop a range of new tests that could lead to new treatments for a number of stress-associated and degenerative disorders of advancing age.

21 Apr 2012

More insight into tangled proteins in Alzheimer's disease

In Alzheimer's disease, brain neurons become clogged with tangled proteins. Scientists suspect these tangles arise partly due to malfunctions in a little-known regulatory system within cells. Now, researchers have dramatically increased what they know about this particular regulatory system in mice. Such information will help scientists better understand Alzheimer's and other diseases in humans and could eventually provide new targets for therapies.

17 Apr 2012

Scientists transform skin cells directly into induced neurons

Until recently, the production of pluripotent "multipurpose" stem cells from skin cells was considered to be the ultimate new development. In the meantime, it has become possible to directly convert cells of the body into one another - without the time-consuming detour via a pluripotent intermediate stage. However, this method has so far been rather inefficient.

12 Apr 2012