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Surgery could boost chemotherapy outcomes in canine TCC

Dogs that undergo curative surgery for transitional cell carcinoma before initiating a combination of doxorubicin and piroxicam therapy have significantly longer median overall survival than their counterparts not pretreated surgically, report researchers.

6 Feb 2013

Tumor suppressor mutant may predict poor outcome in breast cancer

An oncogenic variant of the Krüppel-like family 6 tumor suppressor gene appears to play a role in driving breast cancer metastasis and may be a prognostic marker for poor patient outcome, report researchers.

6 Feb 2013

IsoRay announces presentation video on metastatic brain cancers by Cornell Weill

IsoRay Inc., a medical technology company and innovator in seed brachytherapy and medical radioisotope applications, today announced the presentation video by Cornell Weill demonstrating their techniques in the successful treatment of metastatic brain cancers using IsoRay's patented Cesium-131 (Cs-131) sutured seeds.

6 Feb 2013

Researchers assess complete landscape of kinome expression in cancer

When it comes to gene sequencing and personalized medicine for cancer, spotting an aberrant kinase is a home run. The proteins are relatively easy to target with drugs and plenty of kinase inhibitors already exist.

6 Feb 2013

Women in developed countries survive roughly 10 years longer after breast cancer diagnosis

Women in developed countries survive roughly 10 years longer after a breast cancer diagnosis compared to women in poor-to-middle-income countries, a new University of Michigan study suggests.

6 Feb 2013

Non-coding RNA MALAT1 influences lung cancer metastasis

The vast majority - approximately 80 percent - of our DNA does not code for proteins, yet it gets transcribed into RNA. These RNA molecules are called non-coding and fulfill multiple tasks in the cell. Alongside a well-studied group of small RNAs, there is also a class of so-called long non-coding RNAs consisting of more than 200 nucleotides.

6 Feb 2013

Verastem commences VS-6063 plus paclitaxel Phase 1/1b trial in advanced ovarian cancer

Verastem, Inc., a clinical-stage biopharmaceutical company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced the initiation of a Phase 1/1b trial of VS-6063 in combination with paclitaxel for the treatment of advanced ovarian cancer.

5 Feb 2013

Acceleron Pharma initiates dalantercept phase 2 study in advanced ovarian cancer

Acceleron Pharma, a biopharmaceutical company developing protein therapeutics for cancer and orphan disease, today announced that the Gynecologic Oncology Group (GOG) initiated a phase 2 study of dalantercept in patients with persistent or recurrent ovarian, fallopian tube, or primary peritoneal cancer.

5 Feb 2013

Subclinical hypothyroidism not prognostic in thyroid carcinoma

Subclinical hypothyroidism is not an independent predictor for clinical outcomes in patients with papillary thyroid carcinoma, research shows.

5 Feb 2013

Regular exercise reduces development of painful diabetic neuropathy in animals

Regular exercise reduces the development of painful diabetic neuropathy in animals—apparently related to increased expression of a protective substance called "heat shock protein" 72 (Hsp72), reports an experimental study in the February issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

5 Feb 2013

MammaPrint breast cancer test can help women avoid chemotherapy

The MammaPrint breast cancer test can dramatically reduce the number of women who need to undergo chemotherapy to treat the disease, according to a newly published study.

5 Feb 2013

Results from Merck’s Vorinostat phase 1 trial on lymphoma

Patients whose aggressive lymphomas have relapsed or failed to respond to the current front-line chemotherapy regimen now have an effective second line of attack against their disease.

5 Feb 2013

An Introduction to the LV200 Bioluminescence Microscope

News-Medical speaks to Robert Schmalzigaug to explore the field of bioluminescence imaging and the applications of the LV200 microscope.

From Evident Corporation - Life Sciences 5 Feb 2013

Novian Health completes $11M funding round

Novian Health, developer of Novilase Breast Therapy, announced today that it has successfully completed a funding round totaling $11 million.

5 Feb 2013

New gold nanoparticle can transport powerful radioactive particles directly to tumors

We've all heard that "it's not wise to use a cannon to kill a mosquito." But what if you could focus the cannon's power to concentrate power into a tiny space? In a new study, University of Missouri researchers have demonstrated the ability to harness powerful radioactive particles and direct them toward small cancer tumors while doing negligible damage to healthy organs and tissues.

5 Feb 2013

Accumulation of passenger mutations can slow or even halt tumor growth

A typical cancer cell has thousands of mutations scattered throughout its genome and hundreds of mutated genes. However, only a handful of those genes, known as drivers, are responsible for cancerous traits such as uncontrolled growth. Cancer biologists have largely ignored the other mutations, believing they had little or no impact on cancer progression.

5 Feb 2013

Immune system can use melanoma's own proteins to kill off cancer cells

Though a small group of proteins, the family called Ras controls a large number of cellular functions, including cell growth, differentiation, and survival. And because the protein has a hand in cellular division, mutated Ras, which can be detected in one-third of all tumors, contributes to many human cancers by allowing for the rapid growth of diseased cells.

5 Feb 2013

Cause of esodeviation differs in children, adults

Children who present with acute-onset esodeviation should be investigated for underlying central nervous system disorders, study findings indicate.

4 Feb 2013

Cloaked nanoparticles escape immune system surveillance to reach desired target

By cloaking nanoparticles in the membranes of white blood cells, scientists at The Methodist Hospital Research Institute may have found a way to prevent the body from recognizing and destroying them before they deliver their drug payloads. The group describes its "LeukoLike Vectors", or LLVs, in the January issue of Nature Nanotechnology.

4 Feb 2013

PKCζ protein plays a critical role in regulating tumor metabolism

Cancer cells need food to survive and grow. They're very good at getting it, too, even when nutrients are scarce. Many scientists have tried killing cancer cells by taking away their favorite food, a sugar called glucose. Unfortunately, this treatment approach not only fails to work, it backfires-glucose-starved tumors actually get more aggressive.

2 Feb 2013

Tumor News and Research

Surgery could boost chemotherapy outcomes in canine TCC

Tumor suppressor mutant may predict poor outcome in breast cancer

IsoRay announces presentation video on metastatic brain cancers by Cornell Weill

Researchers assess complete landscape of kinome expression in cancer

Women in developed countries survive roughly 10 years longer after breast cancer diagnosis

Non-coding RNA MALAT1 influences lung cancer metastasis

Verastem commences VS-6063 plus paclitaxel Phase 1/1b trial in advanced ovarian cancer

Acceleron Pharma initiates dalantercept phase 2 study in advanced ovarian cancer

Subclinical hypothyroidism not prognostic in thyroid carcinoma

Regular exercise reduces development of painful diabetic neuropathy in animals

MammaPrint breast cancer test can help women avoid chemotherapy

Results from Merck’s Vorinostat phase 1 trial on lymphoma

An Introduction to the LV200 Bioluminescence Microscope

Novian Health completes $11M funding round

New gold nanoparticle can transport powerful radioactive particles directly to tumors

Accumulation of passenger mutations can slow or even halt tumor growth

Immune system can use melanoma's own proteins to kill off cancer cells

Cause of esodeviation differs in children, adults

Cloaked nanoparticles escape immune system surveillance to reach desired target

PKCζ protein plays a critical role in regulating tumor metabolism

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