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Method of gene therapy accurately corrects mutations in disease-causing genes

Harnessing the strength of a natural process that repairs damage to the human genome, a researcher from UT Southwestern Medical Center has helped establish a method of gene therapy that can accurately and permanently correct mutations in disease-causing genes.

5 Apr 2005

Genomics and proteomics to increase the efficiency of drug discovery and development

While the United Sates is still the world leader, Europe is having a good deal of success in the field of advanced genomics and proteomics research. Significant government funding together with the presence of large pharmaceutical companies has made Europe a major competitor in the efforts to deploy genomics and proteomics as vital tools in drug discovery and development.

5 Apr 2005

Pair of cancer genes found to drive both cell migration and division

Johns Hopkins researchers have found that two genes already known to control cell movement are also needed for proper cell division. They report their findings in the April issue of Developmental Cell.

5 Apr 2005

Method of gene therapy that can accurately and permanently correct mutations in disease-causing genes

4 Apr 2005

Scientists find how pneumonia bacteria get sugar boost to survive

Meningitis and pneumonia bacteria smash into our lungs and cells to steal sugar, which helps them survive, according to research presented from King's College and Guy's Hospital London, (Monday, 04 April 2005) at the Society for General Microbiology's 156th Meeting at Heriot-Watt University, Edinburgh.

4 Apr 2005

Why smokers lung is resistant to steroid treatment

UK researchers think they are close to finding the first effective treatment to fight one of the biggest killer diseases in the UK. Professor Peter Barnes will present the work at the British Endocrine Societies 2005 meeting in Harrogate.

4 Apr 2005

Gene could be cause of early bird disorder

A sleep disorder which makes people nod off early and wake fully alert before dawn is now thought to be caused by a mutant gene.

4 Apr 2005

Scientists identify novel regulator of telomere homeostasis

Each of our 46 chromosomes is capped by a telomere – a long stretch of repeated DNA (TTAGG). Telomeres play a key protective function in our cells, and now Dr. In Kwon Chung and colleagues at Yonsei University (Seoul, Korea) and the University of Central Florida reveal a novel mechanism to modulate telomere length.

3 Apr 2005

Exposure to organochlorine compounds increases the risk of suffering colorectal cancer

A team of researchers at the Universitat Autònoma de Barcelona, The Catalan Institute of Oncology and the Higher Council for Scientific Research (CSIC) have published a study indicating that exposure to organochlorine compounds, which we ingest in our diets, increases the risk of suffering colorectal cancer.

3 Apr 2005

New trial for treatment of liver disease

The Nonalcoholic Steatohepatitis (NASH) Clinical Research Network is launching its first two clinical trials for the study of NASH, a liver disease that resembles alcoholic liver disease but occurs in patients who drink little or no alcohol.

3 Apr 2005

Airway inflammation boosts infarction damage

Epidemiological studies show that the incidence of cardiovascular disease (CVD) complications are increased in long standing cases of asthma. Historically, the complications are often attributed to the chronic drug therapy used to treat asthma.

3 Apr 2005

Could NAADP/cholecystokinin-combo attack fat from inside and out?

One traditional approach to pharmaceutical design uses so-called “first messengers” – hormones, other natural facilitators or synthetic products – to initiate various cellular cascades for the desired physiological effect. To date, despite concerted efforts at all levels of research, this approach has failed to develop a truly successful obesity drug to address this major global health problem.

3 Apr 2005

Discovery of the enzyme that destroys cartilage in inflammatory arthritis

A Melbourne-led team of scientists has discovered the enzyme that destroys cartilage in inflammatory arthritis, offering new hope to sufferers of this painful condition.

30 Mar 2005

Discovery of missing enzyme for tuberculosis iron scavenging pathway

Scientists have discovered that a protein that was originally believed to be involved in tuberculosis antibiotic resistance is actually a "missing enzyme" from the biosynthetic pathway for an agent used by the bacteria to scavenge iron.

30 Mar 2005

CDC experts sent to Angola to help with Marburg epidemic

In an effort to control the Marburg virus outbreak in Angola, Health officials from the Centers for Disease Control and Prevention in Atlanta will assist the World Health Organization by going to Angola to help with outbreak investigation, infection control and laboratory diagnosis of the disease.

30 Mar 2005

A circadian rhythm gene discovered

A few rare people who consistently nod off early, then wake up wide-eyed much before dawn, can blame a newly-found mutant gene for their sleep troubles, Howard Hughes Medical Institute researchers announced today.

30 Mar 2005

DNA sequencing made portable and faster by "colour-blind" technology

Researchers at Baylor College of Medicine (BCM) and Rice University have developed a"colour-blind" method of fluorescence detection which could open new doors that would take DNA sequencing to the patient's bedside, the doctor's office and even the scene of a crime or a battlefield.

29 Mar 2005

Grapes inhibit cancer growth

Components in grapes, including some newly identified ones, work together to dramatically inhibit an enzyme crucial to the proliferation of cancer cells, say scientists at the University of Illinois at Urbana-Champaign.

29 Mar 2005

Researchers discover nicotine demethylase gene

U.S. Smokeless Tobacco Company (USSTC) announced today that scientists at its GenApps Inc. laboratories in Winchester, Kentucky, led by Drs. Mark Nielsen and Dongmei Xu, succeeded in discovering a key tobacco gene encoding nicotine demethylase.

28 Mar 2005

Gene variations explain drug dose required to control seizures

Determining which variants of particular genes patients with epilepsy carry might enable doctors to better predict the dose of drugs necessary to control their seizures, suggest basic findings by researchers at the Duke University Institute for Genome Sciences & Policy (IGSP) and the University College London.

28 Mar 2005