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Heart failure arises from mutations in distinct genes, study finds

Heart failure is a common and devastating disorder for which there is no cure. Many cardiomyopathies -;conditions that make it difficult for the heart to pump blood such as dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) -; can lead to heart failure, but treatments for patients with heart failure do not take these distinct conditions into account.

5 Aug 2022

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Residing within the human gut are trillions of bacteria and other microorganisms that can impact a variety of chronic human ailments, including obesity, type 2 diabetes, atherosclerosis, cancer, non-alcoholic fatty liver disease and inflammatory bowel disease.

4 Aug 2022

Monoclonal antibody protects U.S. adults from malaria, Phase 1 clinical trial shows

One injection of a candidate monoclonal antibody (mAb) known as L9LS was found to be safe and highly protective in U.S. adults exposed to the malaria parasite, according to results from a National Institutes of Health Phase 1 clinical trial published in The New England Journal of Medicine.

4 Aug 2022

UVA researchers receive $15 million from LeDucq Foundation to advance understanding of atherosclerosis

The Boston-based LeDucq Foundation has awarded $15 million to researchers at UVA Health and their collaborators to advance our understanding of atherosclerosis, or hardening of the arteries, and find better ways to treat it.

3 Aug 2022

Children with intellectual disability of genetic origin are extremely likely to develop other neuropsychiatric conditions

A major study of children with intellectual disabilities has highlighted the additional challenges that they often face, including a much-increased likelihood of being diagnosed as autistic, as well as Attention Deficit Hyperactivity Disorder (ADHD) and other mental health difficulties.

3 Aug 2022

Fruit fly genome contains whole genomes of a kind of bacteria, study finds

A fruit fly genome is not a just made up of fruit fly DNA – at least for one fruit fly species. New research from the University of Maryland School of Medicine's (UMSOM) Institute for Genome Sciences (IGS) shows that one fruit fly species contains whole genomes of a kind of bacteria, making this finding the largest bacteria-to-animal transfer of genetic material ever discovered. The new research also sheds light on how this happens.

3 Aug 2022

Finding the lowest effective dose of asthma preventer medicine

Seven out of ten Australians with asthma aged over 12 years may be prescribed too much preventer medicine. In Australian Prescriber Prof Helen Reddel and coauthors from the Woolcock Institute of Medical Research write about finding the lowest effective dose to control asthma.

3 Aug 2022

New research unravels why breastmilk-fed preemies are healthier than formula-fed infants

Human breastmilk has long been considered "liquid gold" among clinicians treating premature infants in a newborn intensive care unit.

2 Aug 2022

New treatment gives hope for people challenged with chronic back pain

People challenged with chronic back pain have been given hope with a new treatment that focuses on retraining how the back and the brain communicate, a randomized controlled trial run by researchers at UNSW Sydney and Neuroscience Research Australia and several other Australian and European universities has shown.

2 Aug 2022

Nasal epithelium of children inhibits infection and replication of ancestral SARS-CoV-2

SARS-CoV-2 causes a broad range of clinical symptoms, including potentially fatal acute respiratory distress syndrome (ARDS).

1 Aug 2022

Brain & Behavior Research Foundation recognizes exceptional research in mental illness

The Brain & Behavior Research Foundation today announced the winners of its 2022 Klerman and Freedman Prizes, recognizing exceptional clinical and basic research in mental illness.

1 Aug 2022

NIH updates its strategic plan for hepatitis B research

The National Institutes of Health has updated its Strategic Plan for NIH Research to Cure Hepatitis B, a roadmap for ending the hepatitis B epidemic, focused on developing a cure as well as improved strategies for vaccination, screening and follow-up care.

1 Aug 2022

Researchers find mechanisms behind the development of congenital birth defect

About one percent of the world population is born with a congenital heart defect, which affects about 40,000 U.S. births each year, but how these particular birth defects come about is largely unknown.

1 Aug 2022

Insufficient sleep could have long-lasting impact on the neurocognitive development of pre-teens

Elementary school-age children who get less than nine hours of sleep per night have significant differences in certain brain regions responsible for memory, intelligence and well-being compared to those who get the recommended nine to 12 hours of sleep per night, according to a new study led by University of Maryland School of Medicine researchers.

29 Jul 2022

Novel algorithm identifies adverse drug events across the seven pediatric development stages

Side effects from pediatric drug treatment are responsible for nearly 10 percent of childhood hospitalizations, with nearly half of those being life-threatening. Despite the need to know more about these drugs and the adverse events they can have on children, little evidence is currently available.

28 Jul 2022

New method for organoid production could help advance research studies

As the idea of growing tiny human organs in lab dishes has moved in recent years from futuristic science fiction to actual bioscientific reality, the usefulness of organoids as a research tool for studying the digestive system swiftly encountered a bottleneck-;these valuable tissues are quite difficult to make.

28 Jul 2022

New imaging technique reveals subtle details about pathology in a rare eye disease

Using a new imaging technique, researchers from the National Eye Institute have determined that retinal lesions from vitelliform macular dystrophy (VMD) vary by gene mutation.

28 Jul 2022

New discovery may open the door to targeted treatments for two types of rhabdomyosarcoma

A gene that UVA Health researchers discovered is responsible for the deadliest type of brain tumor is also responsible for two forms of childhood cancer, the scientists have found.

28 Jul 2022

Winners of NIH Technology Accelerator Challenge for Maternal Health announced

The National Institutes of Health today announced the winners of its NIH Technology Accelerator Challenge (NTAC) for Maternal Health, a prize competition for developers of diagnostic technologies to help improve maternal health around the world.

28 Jul 2022

Oncology trial data not available for independent scrutiny, study finds

Despite a commitment from the pharmaceutical industry in 2014 to improve data transparency, more than half of the clinical trials that led to the United States Food and Drug Administration approving anticancer medicines over the past 10 years are not available for independent scrutiny, a multi-national study led by Flinders University has found.

28 Jul 2022

Medical Research News and Research

Heart failure arises from mutations in distinct genes, study finds

Using native microbes as chassis for transgene delivery in live bacterial therapeutics

Monoclonal antibody protects U.S. adults from malaria, Phase 1 clinical trial shows

UVA researchers receive $15 million from LeDucq Foundation to advance understanding of atherosclerosis

Children with intellectual disability of genetic origin are extremely likely to develop other neuropsychiatric conditions

Fruit fly genome contains whole genomes of a kind of bacteria, study finds

Finding the lowest effective dose of asthma preventer medicine

New research unravels why breastmilk-fed preemies are healthier than formula-fed infants

New treatment gives hope for people challenged with chronic back pain

Nasal epithelium of children inhibits infection and replication of ancestral SARS-CoV-2

Brain & Behavior Research Foundation recognizes exceptional research in mental illness

NIH updates its strategic plan for hepatitis B research

Researchers find mechanisms behind the development of congenital birth defect

Insufficient sleep could have long-lasting impact on the neurocognitive development of pre-teens

Novel algorithm identifies adverse drug events across the seven pediatric development stages

New method for organoid production could help advance research studies

New imaging technique reveals subtle details about pathology in a rare eye disease

New discovery may open the door to targeted treatments for two types of rhabdomyosarcoma

Winners of NIH Technology Accelerator Challenge for Maternal Health announced

Oncology trial data not available for independent scrutiny, study finds

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