Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Electron microscopy project could revolutionize the search for new drugs

The search for new drugs to combat diseases more effectively could be revolutionized through a new £30 million electron microscopy project.

17 May 2019

Marine natural compounds could be potential treatments for triple negative breast cancer

The oceans cover more than 70 percent of the earth's surface and provide a rich source of unique, bioactive natural products.

17 May 2019

CRISPR uncovers which gene fusions are critical for growth of cancer cells

In the first large-scale analysis of cancer gene fusions, which result from the merging of two previously separate genes, researchers at the Wellcome Sanger Institute, EMBL-EBI, Open Targets, GSK and their collaborators have used CRISPR to uncover which gene fusions are critical for the growth of cancer cells.

16 May 2019

Big data helps determine better research models to fight the spread of breast cancer

Scientists are using a lot of genomic data to identify medical issues sooner in patients, but they're also using it to assist their scientific counterparts in researching diseases better.

15 May 2019

MDI Biological Laboratory receives $30,000 to support course in organoid technology

The MDI Biological Laboratory has announced that it has received more than $30,000 in cash and in-kind awards in support of its second annual "Applications of Organoid Technology" course, to be held May 26 through June 1 at the institution's Bar Harbor campus.

14 May 2019

Six plants native to Southeast Asia show cancer-fighting properties

A team of researchers from the National University of Singapore has recently discovered that the Bandicoot Berry (Leea indica), South African leaf (Vernonia amygdalina) and Simple leaf Chastetree (Vitex trifolia), which are favorite nectaring plants of butterflies, do more than attract butterflies.

13 May 2019

New drug targeting genetic weakness could become first treatment for childhood brain cancer

A new type of drug that targets a genetic weakness in an untreatable childhood brain cancer could become the first ever treatment designed to target the disease.

9 May 2019

Small molecule drug may help overcome ibrutinib resistance in mantle cell lymphona

A study at The University of Texas MD Anderson Cancer Center demonstrated how a small molecule drug discovered at the institution may help overcome resistance to treatment with ibrutinib in patients with mantle cell lymphoma.

9 May 2019

Aptamer Therapeutics collaborates with Cancer Research UK for drug development program

Following the successful awarding of a CRUK Biotherapeutic Drug Discovery Project Award, Aptamer Therapeutics Limited, part of Aptamer Group, is pleased to announce a new collaboration with Dan Wiseman and the Oglesby Leukemia Research Program at the University of Manchester and Cancer Research UK.

From Aptamer Group 6 May 2019

New HKBU method could lead to the production of higher quality medicinal drugs

Physics and Chemistry scholars from Hong Kong Baptist University (HKBU) have invented a new method which could speed up the drug discovery process and lead to the production of higher quality medicinal drugs which are purer and have no side effects.

29 Apr 2019

New chemical synthesis strategy leads to identification of novel, simpler derivatives

A new chemical synthesis strategy to harvest the rich information found in natural products -- organic compounds isolated from natural sources -- has led to the identification of novel, simpler derivatives with potential to selectively protect neurons, important for neurodegenerative diseases like Alzheimer's disease, or to prevent the immune system from rejecting organ transplants, according to a Baylor University-led study.

25 Apr 2019

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania talks to News-Medical and Life Sciences about the importance of light scattering techniques for investigating structure and mechanism of action in his ongoing research into HIV integrase and the development of HIV therapeutics.

From Waters | Wyatt Technology 24 Apr 2019

Scientists identify 104 high-risk genes for schizophrenia

Using a unique computational "framework" they developed, a team of scientist cyber-sleuths in the Vanderbilt University Department of Molecular Physiology and Biophysics and the Vanderbilt Genetics Institute has identified 104 high-risk genes for schizophrenia.

23 Apr 2019

New discovery transforms conventional microfluidics into open-space microfluidics

Microfluidics refers to the manipulation of fluids in microscale devices. Commonly called "labs on a chip," microfluidic systems are used to study and analyze very small-scale chemical or biological samples, replacing the extremely expensive and cumbersome instruments used for traditional biological analyses.

19 Apr 2019

Scientists enter research collaboration to find a cure for cancer

Cancer is a disease that afflicts an alarming number of people, with one in two being diagnosed with a type of cancer during their lifetime.

17 Apr 2019

Researchers create new small molecules that may combat equine encephalitis viruses

Viruses without a preventative vaccine or treatment option pose a looming threat. But for viruses in this category that have already been weaponized and are recognized as human biothreats by the Centers for Disease Control and Prevention, it's a race to find a cure.

17 Apr 2019

Using slime mold to produce accessible biosensors

An EU-funded project is using slime mold to produce accessible sensing devices with a wide range of applications, including environmental monitoring and health - helping European industry become more competitive in the growing biosensor device market.

15 Apr 2019

Drug Discovery News and Research

Further Reading

Electron microscopy project could revolutionize the search for new drugs

Marine natural compounds could be potential treatments for triple negative breast cancer

CRISPR uncovers which gene fusions are critical for growth of cancer cells

Big data helps determine better research models to fight the spread of breast cancer

MDI Biological Laboratory receives $30,000 to support course in organoid technology

Six plants native to Southeast Asia show cancer-fighting properties

New drug targeting genetic weakness could become first treatment for childhood brain cancer

Small molecule drug may help overcome ibrutinib resistance in mantle cell lymphona

Aptamer Therapeutics collaborates with Cancer Research UK for drug development program

New HKBU method could lead to the production of higher quality medicinal drugs

New chemical synthesis strategy leads to identification of novel, simpler derivatives

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

Scientists identify 104 high-risk genes for schizophrenia

New discovery transforms conventional microfluidics into open-space microfluidics

Scientists enter research collaboration to find a cure for cancer

Researchers create new small molecules that may combat equine encephalitis viruses

Using slime mold to produce accessible biosensors

Biomolecular researcher provides comprehensive profile of B cells in rheumatoid arthritis

Study describes vulnerability shared by large subset of cancer cell lines

USC researchers report breakthrough to prevent osteonecrosis of the jaw

eBook: Essential guide to organoids in drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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